| Project/Area Number |
18K06010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
Matsuura Yuichi 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上級研究員 (60398089)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | プリオン / 牛海綿状脳症 / 感染性 / 遺伝子改変マウス / 感染 |
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| Outline of Final Research Achievements |
There are three types of bovine spongiform encephalopathy prions with different biological characteristics. For the purpose of revealing regions related to the characteristics, these prions were subjected to experimental infection in transgenic mice expressing PrPC lacking the non-structural region of the amino terminus. These mice were infected with some prions, but not with others. However, it was shown that the lacking region did not affect the structural conversion and retention of biological properties by prions. Therefore, the conversion process can lead to the determination of prion characteristics.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、異常化したプリオン蛋白質の立体構造がプリオン性状の決定に関わると考えられている。しかし、本研究で示したプリオン生成過程によるプリオン性状の差異・保持への関与はプリオン病の学術的に新たな視点を提供する。また、未だに有効な治療法のないヒトのプリオン病の治療薬開発にも新たな視点を提供することが期待される。
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