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Elucidation of the molecular control mechanisms of dopamine signaling in the neural circuit for action selection of mating.

Research Project

Project/Area Number 18K06332
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionNagoya University

Principal Investigator

Ishimoto Hiroshi  名古屋大学, 理学研究科, 特任准教授 (80643361)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsドーパミン / 配偶行動 / 意思決定 / 行動選択 / フィードフォワード / フィードバック / ショウジョウバエ / 性行動 / モチベーション / フィードフォワード回路 / 逆行性シナプス伝達 / GABA / Gタンパク質共役型受容体 / Ca2+イメージング
Outline of Final Research Achievements

In the mating behavior, females do not immediately accept the courtship from males, but rather evaluate their mates first before accepting them for mating. We found a neural circuit that controls this behavioral switch from pre-mating rejection to acceptance in Drosophila, and found that different dopamine receptors control the activity in each of the neurons that make up the circuit. In this study, we physiologically analyzed the dopamine response of the neurons that make up the circuit in order to clarify how dopamine signals control the behavior of this circuit. The results suggest that the neural response patterns depend on the presence or absence of connections between neurons and the duration of dopamine input, and that these patterns may be consistent with behavioral switching in females.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、交尾の配偶行動を選択決定する脳機能を担う神経回路において、ドーパミンという単一の神経伝達分子を用いながら、複数の回路挙動を分岐させる神経回路の動作原理を細胞レベルでその解明に迫った、という学術的な意義がある。この神経回路は、哺乳類の大脳基底核と機能的な類似性を示す。異性に対する親愛性、仲間との絆形成といった、他者と自己の関係性を構築するための脳の基本原理を解くために、本研究で得た知見を様々な生物間で比較することが可能になった。これにより、個体間コミュニケーションの獲得と進化の謎を解くことが期待され、また、対人関係に関わる社会問題や疾患の解決と治療に新たな方法を提供しうる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2021 2020 2019 2018 Other

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Remarks (7 results)

  • [Journal Article] Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila2021

    • Author(s)
      Ishimoto Hiroshi、Kamikouchi Azusa
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: Apr 10. Issue: 10 Pages: 4805-4819

    • DOI

      10.1007/s00018-021-03820-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Feedforward Circuit Regulates Action Selection of Pre-mating Courtship Behavior in Female Drosophila.2020

    • Author(s)
      Hiroshi Ishimoto,Azusa Kamikouchi
    • Journal Title

      Current biology

      Volume: 30 Issue: 3 Pages: 396-407

    • DOI

      10.1016/j.cub.2019.11.065

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <em>Ex Vivo</em> Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in <em>Drosophila</em>2018

    • Author(s)
      Ishimoto Hiroshi、Sano Hiroko
    • Journal Title

      Journal of Visualized Experiments

      Volume: 136 Issue: 136

    • DOI

      10.3791/57701

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] GABAergic local interneurons shape female fruit fly response to mating songs2018

    • Author(s)
      Daichi Yamada, Hiroshi Ishimoto, Xiaodong Li, Tsunehiko Kohashi, Yuki Ishikawa, Azusa Kamikouchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 印刷中 Issue: 18 Pages: 4329-4347

    • DOI

      10.1523/jneurosci.3644-17.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Auditory experience controls the maturation of song discrimination and sexual response in Drosophila2018

    • Author(s)
      Xiaodong Li, Hiroshi Ishimoto, Azusa Kamikouchi
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.34348

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessing Experience-dependent Tuning of Song Preference in Fruit Flies (Drosophila melanogaster)2018

    • Author(s)
      Li Xiaodong、Ishimoto Hiroshi、Kamikouchi Azusa
    • Journal Title

      BIO-PROTOCOL

      Volume: 8 Issue: 14

    • DOI

      10.21769/bioprotoc.2932

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A feedforward circuit in the ellipsoid body regulates action selection of pre-mating courtship behavior in female Drosophila2020

    • Author(s)
      Hiroshi Ishimoto
    • Organizer
      第43回日本神経科学学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A feedforward circuit controls pre-mating courtship response via a reciprocal signaling systems in female Drosophila.2019

    • Author(s)
      石元広志, 上川内あづさ
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A feedforward circuit in the central complex regulates action selection of pre-mating courtship behavior in female Drosophila2019

    • Author(s)
      石元広志, 上川内あづさ
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 交尾意思決定を制御するショウジョウバエのフィードフォワード神経回路2018

    • Author(s)
      石元広志, 上川内あづさ
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Dopaminergic control of a central circuit for the decision-make process of female mating.2018

    • Author(s)
      Hiroshi Ishimoto and Azusa Kamikouchi
    • Organizer
      第13回日本ショウジョウバエ研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 求愛記憶の詳細定量法2018

    • Author(s)
      石元広志
    • Organizer
      第11回分子高次機能研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] A feedforward circuit regulates decision-make process of mating in female Drosophila.2018

    • Author(s)
      Hiroshi Ishimoto and Azusa Kamikouchi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 第35回論文紹介(2020.7更新)名古屋大学

    • URL

      https://www.bio.nagoya-u.ac.jp/paper/2020-35/03.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 名古屋大学 栄養神経科学講座

    • URL

      https://nsi.bio.nagoya-u.ac.jp/jp/groups/nn

    • Related Report
      2020 Annual Research Report
  • [Remarks] 愛の獲得には、継続的な求愛が必要 ~世界初、拒否と受容の行動切替メカニズムを解明!~

    • URL

      http://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20200106_sci1.pdf

    • Related Report
      2019 Research-status Report
  • [Remarks] 朝日新聞:ハエの世界、求愛繰り返せば効果あり メスの行動が変化

    • URL

      https://www.asahi.com/articles/ASMDM62XHMDMOIPE02J.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 読売新聞:オスがめげずに求愛、メスは拒否から受け入れへ…実験で明らかに

    • URL

      https://www.yomiuri.co.jp/science/20200104-OYT1T50148/

    • Related Report
      2019 Research-status Report
  • [Remarks] 毎日新聞:「求愛拒否から受け入れへ」脳の仕組み解明 ハエの研究で 名大チームら

    • URL

      https://mainichi.jp/articles/20200102/k00/00m/040/213000c

    • Related Report
      2019 Research-status Report
  • [Remarks] 時事通信:ハエの求愛、粘りが大事 雌が拒否から受容へ―脳の仕組み解明・名古屋大

    • URL

      https://www.jiji.com/jc/article?k=2020010300036&g=soc

    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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