| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Fifty steroidal compounds including new compounds were isolated from Ranunculaceae, Poaceae, and Apocynaceae plants for the purpose of searching for new seed compounds of cancer molecular-targeted agents. Among them, steroidal compounds isolated from the genus Helleborus (Ranunculaceae) had potent cytotoxicity to human cancer cells, and induced apoptosis by a mitochondrial mediated pathway and arrested cell cycle progression in G2/M phase in human leukemia cells.
|
