| Project/Area Number |
18K07637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Yokohama City University |
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Principal Investigator |
YONEDA Masato 横浜市立大学, 附属病院, 准教授 (10423831)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 非アルコール性脂肪性肝疾患 / 肝硬変 / 肝細胞癌 / Focal cirrhosis / NASH / NAFLD / MRエラストグラフィー / 肝線維化 / 非アルコール性脂肪肝炎 |
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| Outline of Final Research Achievements |
In the manegement of chronic liver disease, it is essential to correctly assess the degree of hepatic fibrosis for appropriate surveillance of hepatocellular carcinoma. In this study, we compared the diagnostic performance of ultrasound elastography and MR elastography, which are currently used as noninvastive tests (NITs). We also examined the heterogeneity of fibrosis distribution in the liver (focal cirrhosis) by MR elastography. The diagnostic performance of MRE for fibrotic liver was higher than that of other ultrasound elastography, and the hepatic heterogeneity was as high as 30% in the same liver. The heterogeneity of liver hardness was associated with discordance with pathological biopsy.
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| Academic Significance and Societal Importance of the Research Achievements |
非アルコール性脂肪性肝疾患（NAFLD）は最多の肝疾患であり，新規肝細胞癌発症患者の原因肝疾患としても増加傾向となっている．米国消化器病学会は2020年にNAFLD患者におけるHCCサーベイランスを行うが，高度線維化のないNAFLDではルーチンの肝細胞癌のスクリーニングは費用対効果から行うべきではないとの提言であった．しかしNAFLDの場合，肝臓内に不均一に線維化が進行して、一部が硬変肝になることがあり（Focal cirrhosis），本研究の概念により今後のHCCサーベイランス方針を変更しうる可能性を持つ．
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