Feature value analysis of delivered dose distribution contributing to individualized radiotherapy

• Project/Area Number: 18K07667
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: The University of Tokyo
• Principal Investigator: Imae Toshikazu 東京大学, 医学部附属病院, 副診療放射線技師長 (80420222)
• Co-Investigator(Kenkyū-buntansha): 芳賀 昭弘 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30448021) ; 山下 英臣 東京大学, 医学部附属病院, 准教授 (70447407) ; 高橋 渉 東京大学, 医学部附属病院, 助教 (50755668) ; 鈴木 雄一 東京大学, 医学部附属病院, 副診療放射線技師長 (70420221)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線治療 / 個別化 / 投与線量分布 / 特徴量 / 形態変化

Outline of Final Research Achievements

This study aimed to reconstruct the dose distribution that reflects the patient's shape and the device movement during treatment, and to clarify the feature value that causes the error between the dose distribution and the treatment plan. We created the delivered dose distribution using non-rigid registration and deep learning approaches. In addition, we extracted feature values for the therapeutic and side effects of stereotactic body radiation therapy using radiomics analysis and clarified that specific feature values indicate clinical usefulness.

Academic Significance and Societal Importance of the Research Achievements

本研究では，非剛体レジストレーションを用いた投与線量分布の作成や深層学習を用いた画質改善法の提案，体幹部定位放射線治療における治療効果と副作用，また，レディオミクス解析を用いて抽出した特徴量の臨床的有用性を示した．治療効果や副作用に直結する投与線量分布の作成や投与線量分布と治療計画の誤差要因の明確化，また，治療後の患者に対する詳細な解析結果は，今後の放射線治療の個別化や最適化に貢献する．

Research Products

• [Journal Article] Establishment of a Prediction Model for Overall Survival after Stereotactic Body Radiation Therapy for Primary Non-Small Cell Lung Cancer Using Radiomics Analysis (2022)
  • Author(s): Subaru Sawayanagi, Hideomi Yamashita, Yuki Nozawa, Ryosuke Takenaka, Yosuke Miki, Kosuke Morishima, Hiroyuki Ueno, Takeshi Ohta, Atsuto Katano.
  • Journal Title: Cancers (Basel) Volume: 14 Issue: 16 Pages: 3859-3859
  • DOI: 10.3390/cancers14163859
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Improvement in Image Quality of CBCT during Treatment by Cycle Generative Adversarial Network (2020)
  • Author(s): 今江 禄一, 鍛冶 静雄, 木田 智士, 松田 佳奈子, 竹中 重治, 青木 淳, 仲本 宗泰, 尾崎 翔, 名和 要武, 山下 英臣, 中川 恵一, 阿部 修．
  • Journal Title: Japanese Journal of Radiological Technology Volume: 76 Issue: 11 Pages: 1173-1184
  • DOI: 10.6009/jjrt.2020_JSRT_76.11.1173
  • NAID: 130007941322
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective dose reconstruction of prostate stereotactic body radiotherapy using cone-beam CT and a log file during VMAT delivery with flattening-filter-free mode (2020)
  • Author(s): Imae Toshikazu，Haga Akihiro，Watanabe Yuichi，Takenaka Shigeharu，Shiraki Takashi，Nawa Kanabu，Ogita Mami，Takahashi Wataru，Yamashita Hideomi，Nakagawa Keiichi，Abe Osamu．
  • Journal Title: Radiological Physics and Technology Volume: 13 Issue: 3 Pages: 238-248
  • DOI: 10.1007/s12194-020-00574-3
  • Peer Reviewed / Open Access
• [Journal Article] Visual enhancement of Cone‐beam CT by use of CycleGAN (2020)
  • Author(s): Kida S, Kaji S, Nawa K, Imae T, Nakamoto T, Ozaki S, Ohta T, Nozawa Y, Nakagawa K.
  • Journal Title: Medical Physics Volume: 47(3) Issue: 3 Pages: 998-1010
  • DOI: 10.1002/mp.13963
  • Peer Reviewed / Open Access
• [Journal Article] Salvage stereotactic body radiotherapy for post?operative oligo?recurrence of non?small cell lung cancer: A single?institution analysis of 59?patients (2020)
  • Author(s): Aoki S, Yamashita H, Takahashi W, Nawa K, Ota T, Imae T, Ozaki S, Nozawa Y, Nakajima J, Sato M, Anraku M, Nitadori J, Karasaki T, Abe O, Nakagawa K.
  • Journal Title: Oncology Letters Volume: 19（4） Pages: 2695-2704
  • DOI: 10.3892/ol.2020.11407
  • Peer Reviewed / Open Access
• [Journal Article] Stereotactic body radiotherapy for centrally located lung tumors with 56 Gy in seven fractions: A retrospective study (2018)
  • Author(s): Aoki Shuri、Yamashita Hideomi、Haga Akihiro、Ota Takeshi、Takahashi Wataru、Ozaki Sho、Nawa Kanabu、Imae Toshikazu、Abe Osamu、Nakagawa Keiichi
  • Journal Title: Oncology Letters Volume: 16(4) Pages: 4498-4506
  • DOI: 10.3892/ol.2018.9188
  • NAID: 120007099373
  • Peer Reviewed / Open Access
• [Presentation] 深層学習により画質改善したCBCT画像を用いた積算線量分布の構築 (2022)
  • Author(s): 竹中重治，今江禄一，青木淳，松田佳奈子，境紀行，鍛冶静雄，岩永秀幸，山下英臣，阿部修．
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] 深層学習を用いて画質改善した位置合わせ用CBCT上における線量分布の再構築 (2021)
  • Author(s): 今江禄一，青木淳，竹中重治，松田佳奈子，三枝茂輝，鍛冶静雄，岩永秀幸，阿部修．
  • Organizer: 第49回日本放射線技術学会秋季学術大会
• [Presentation] Cone-beam CT image quality improvement with Cycle-Consistency Generative Adversarial Network. (2019)
  • Author(s): S Kida, S Kaji, K Nawa, T Imae, T Nakamoto, S Ozaki, T Ohta, Y Nozawa and N Keiichi.
  • Organizer: 第117回日本医学物理学会大会
• [Presentation] Image quality improvement of cone beam CT image reconstruction during treatment. (2019)
  • Author(s): K Mano, T Hashimoto and T Imae.
  • Organizer: 第117回日本医学物理学会大会
• [Presentation] 班報告：高精度放射線治療における包括的かつ実用的な投与線量保証法に関する研究班． (2019)
  • Author(s): 今江禄一，渡邉雄一，辰己大作，藤本隆広，佐々木誠，佐々木幹治，中口裕二，阿部 修．
  • Organizer: 第47回日本放射線技術学会秋季学術大会
• [Presentation] Pseudo-CBCT Image Prediction of Head and Neck Cancer Patient Using Principal Component Vector Fields of Early Treatment Fractions. (2019)
  • Author(s): M Nakano, T Imae, T Nakamoto, A Haga, K Nawa, Y Nomura, R Chhatkuli, K Demachi, W Takahashi, K Yamamoto, K Nakagawa, M Hashimoto, Y Yoshioka, M Oguchi,
  • Organizer: American Association of Physicists in Medicine 61st Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Pseudo-CBCT image prediction of head and neck cancer patient using principal component vector fields of early treatment fractions. (2019)
  • Author(s): M Nakano, T Imae, T Nakamoto, K Nawa, A Haga, W Takahashi, K Nakagawa, M Hashimoto, Y Yoshioka and M Oguchi.
  • Organizer: 第117回日本医学物理学会学術大会
• [Book] 詳説非剛体レジストレーション : 放射線治療領域 (2020)
  • Author(s): 角谷 倫之，木藤 哲史，黒岡 将彦，武川 英樹，藤田 幸男，宮部 結城．
  • Total Pages: 264
  • Publisher: 中外医学社
  • ISBN: 9784498065284
• [Remarks] researchmap: 今江禄一
  • URL: https://researchmap.jp/m035402
• [Remarks] 東京大学医学部附属病院 放射線科 放射線治療部門 > 研究・業績
  • URL: http://u-tokyo-rad.jp/works/index.html