Application of high-precision denoising technique with deep learning to neuroimaging research

• Project/Area Number: 18K07712
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Oishi Naoya 京都大学, 医学研究科, 特定准教授 (40526878)
• Co-Investigator(Kenkyū-buntansha): 藤原 宏志 京都大学, 情報学研究科, 准教授 (00362583) ; 鈴木 崇士 京都大学, 医学研究科, 特定助教 (10572224) ; 杉原 玄一 京都大学, 医学研究科, 助教 (70402261)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 深層学習 / MRI / 脳 / 精神神経疾患 / ノイズ除去 / GPGPU / 医用画像工学

Outline of Final Research Achievements

In order to improve the signal-to-noise ratio in neuroimaging research, we have newly developed a deep learning-based high-precision denoising algorithm for brain MRI. For small animals, the usefulness of denoising in morphological MRI of psychiatric model rats was clarified. Furthermore, by extending the method, we succeeded in improving the prognosis prediction performance of patients with neuropsychiatric disorders. Thus, we have clarified the usefulness of the deep learning-based high-precision denoising algorithm developed this time for both basic and clinical applications.

Academic Significance and Societal Importance of the Research Achievements

柔軟性・拡張性の高い深層学習ベースのノイズ除去アルゴリズムを新規に開発し、精神疾患モデルラットの形態MRIに応用することで従来検出しえなかった微小領域の変化を捉えることに成功した点は学術的意義が高いと考えられる。また、本手法を拡張することでMRIから縮約された情報を抽出させ、精神神経疾患患者の予後予測性能向上を果たした点は将来的な臨床応用という観点で社会的意義も高い。

Research Products

• [Journal Article] Autistic traits are associated with the functional connectivity of between?but not within?attention systems in the general population (2020)
  • Author(s): Yoshimura Sayaka、Kobayashi Kei、Ueno Tsukasa、Miyagi Takashi、Oishi Naoya、Murai Toshiya、Fujiwara Hironobu
  • Journal Title: BMC Neuroscience Volume: 21 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s12868-020-00603-2
  • Peer Reviewed / Open Access
• [Journal Article] Intact in vivo visualization of telencephalic microvasculature in medaka using optical coherence tomography (2020)
  • Author(s): Suzuki Takashi、Ueno Tomohiro、Oishi Naoya、Fukuyama Hidenao
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 19831-19831
  • DOI: 10.1038/s41598-020-76468-6
  • NAID: 120006898162
  • Peer Reviewed / Open Access
• [Journal Article] <p>Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using ¹⁸F-FPYBF-2 PET</p> (2020)
  • Author(s): Ubukata Shiho、Oishi Naoya、Higashi Tatsuya、Kagawa Shinya、Yamauchi Hiroshi、Okuyama Chio、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Aso Toshihiko、Murai Toshiya、Ueda Keita
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 16 Pages: 2719-2732
  • DOI: 10.2147/ndt.s268504
  • Peer Reviewed / Open Access
• [Journal Article] Psychological resilience is correlated with dynamic changes in functional connectivity within the default mode network during a cognitive task (2020)
  • Author(s): Miyagi Takashi、Oishi Naoya、Kobayashi Kei、Ueno Tsukasa、Yoshimura Sayaka、Murai Toshiya、Fujiwara Hironobu
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 17760-17760
  • DOI: 10.1038/s41598-020-74283-7
  • NAID: 120007006217
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between media multitasking and functional connectivity in the dorsal attention network (2020)
  • Author(s): Kobayashi Kei、Oishi Naoya、Yoshimura Sayaka、Ueno Tsukasa、Miyagi Takashi、Murai Toshiya、Fujiwara Hironobu
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 17992-17992
  • DOI: 10.1038/s41598-020-75091-9
  • Peer Reviewed / Open Access
• [Journal Article] Deep learning-derived high-level neuroimaging features predict clinical outcomes for large vessel occlusion (2020)
  • Author(s): Nishi H, *Oishi N, Ishii A, Ono I, Ogura T, Sunohara T, Chihara H, Fukumitsu R, Okawa M, Yamana N, Imamura H, Sadamasa N, Hatano T, Nakahara I, Sakai N, Miyamoto S
  • Journal Title: Stroke Volume: 51 Issue: 5 Pages: 1484-1492
  • DOI: 10.1161/strokeaha.119.028101
  • Peer Reviewed / Open Access
• [Journal Article] 境界積分によるX線計算機断層撮影法の正則化 (2020)
  • Author(s): *藤原宏志、大石直也
  • Journal Title: 計算数理工学論文集（JASCOME） Volume: 20 Pages: 04-201219
  • Peer Reviewed / Open Access
• [Journal Article] Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease (2019)
  • Author(s): Yamauchi Hiroshi、Kagawa Shinya、Takahashi Masaaki、Oishi Naoya、Ono Masahiro、Higashi Tatsuya
  • Journal Title: NeuroImage: Clinical Volume: 22 Pages: 101762-101762
  • DOI: 10.1016/j.nicl.2019.101762
  • Peer Reviewed / Open Access
• [Journal Article] Martial arts “Kendo” and the motivation network during attention processing: an fMRI study (2019)
  • Author(s): Fujiwara H, Ueno T, Yoshimura S, Kobayashi K, Miyagi T, Oishi N, Murai T
  • Journal Title: Front. Hum. Neurosci. Volume: 13 Pages: 170-170
  • DOI: 10.3389/fnhum.2019.00170
  • NAID: 120006773155
  • Peer Reviewed / Open Access
• [Journal Article] Predicting clinical outcomes of large vessel occlusion before mechanical thrombectomy using machine learning (2019)
  • Author(s): Nishi H, Oishi N, Ishii A, Ono I, Ogura T, Sunohara T, Chihara H, Fukumitsu R, Okawa M, Yamana N, Imamura H, Sadamasa N, Hatano T, Nakahara I, Sakai N, Miyamoto S
  • Journal Title: Stroke Volume: 50 Pages: 2379-2388
  • Peer Reviewed / Open Access
• [Journal Article] Nigrostriatal Dopaminergic Dysfunction And Altered Functional Connectivity In REM Sleep Behaviour Disorder With Mild Motor Impairment (2019)
  • Author(s): Yamada G, Ueki Y, Oishi N, Oguri T, Fukui A, Nakayama M, Kandori A, Sano Y, Kan H, Arai N, Sakurai K, Wada I, Matsukawa N
  • Journal Title: Front. Neurol. Volume: 10 Pages: 802-802
  • DOI: 10.3389/fneur.2019.00802
  • Peer Reviewed / Open Access
• [Journal Article] Transcallosal Fiber Disruption and its Relationship with Corresponding Gray Matter Alteration in Patients with Diffuse Axonal Injury (2018)
  • Author(s): Ubukata Shiho、Oishi Naoya、Sugihara Genichi、Aso Toshihiko、Fukuyama Hidenao、Murai Toshiya、Ueda Keita
  • Journal Title: Journal of Neurotrauma Volume: - Issue: 7 Pages: 1106-1114
  • DOI: 10.1089/neu.2018.5823
  • Peer Reviewed / Open Access
• [Journal Article] 18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia (2018)
  • Author(s): Higashi Tatsuya、Nishii Ryuichi、Kagawa Shinya、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
  • Journal Title: Ann Nucl Med Volume: 32 Issue: 3 Pages: 206-216
  • DOI: 10.1007/s12149-018-1236-1
  • Peer Reviewed / Open Access
• [Journal Article] 18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging (2018)
  • Author(s): Nishii Ryuichi、Higashi Tatsuya、Kagawa Shinya、Okuyama Chio、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
  • Journal Title: Ann Nucl Med Volume: 32 Issue: 4 Pages: 256-263
  • DOI: 10.1007/s12149-018-1240-5
  • Peer Reviewed / Open Access
• [Journal Article] Sex-specific regional grey matter volume correlates of daily activities (2018)
  • Author(s): Ueno Tsukasa、Oishi Naoya、Murai Toshiya
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-018-28252-w
  • NAID: 120006489935
  • Peer Reviewed / Open Access
• [Journal Article] Montreal Cognitive Assessment score correlates with regional cerebral blood flow in post-stroke patients (2018)
  • Author(s): Nakaoku Yuriko、Oishi Naoya、Hase Yoshiki、Hase Mai、Saito Satoshi、Mitsueda Takahiro、Matsui Masaru、Toyoda Kazunori、Nagatsuka Kazuyuki、Kalaria Raj N.、Fukuyama Hidenao、Ihara Masafumi、Takahashi Ryosuke
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 174 Pages: 68-74
  • DOI: 10.1016/j.clineuro.2018.09.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Simultaneous infrared thermal imaging and laser speckle imaging of brain temperature and cerebral blood flow in rats (2018)
  • Author(s): Suzuki Takashi、Oishi Naoya、Fukuyama Hidenao
  • Journal Title: Journal of Biomedical Optics Volume: 24 Issue: 03 Pages: 1-1
  • DOI: 10.1117/1.jbo.24.3.031014
  • Peer Reviewed / Open Access
• [Journal Article] Neural correlates of non-clinical internet use in the motivation network and its modulation by subclinical autistic traits (2018)
  • Author(s): Fujiwara, Hironobu
  • Journal Title: Frontiers in Human Neuroscience Volume: 12 Pages: 1-11
  • DOI: 10.3389/fnhum.2018.00493
  • NAID: 120006547377
  • Peer Reviewed / Open Access
• [Presentation] MRI の機械学習による認知症の鑑別診断 (2020)
  • Author(s): 大石直也
  • Organizer: 第39回日本認知症学会学術集会
  • Invited
• [Presentation] 心房細動患者における機械学習を用いた脳卒中発症予測 (2020)
  • Author(s): 西 秀久、大石 直也、赤尾 昌治、小川 尚、岸田 夏枝、土井 健人、川上 理、青木 友和、福田 俊一、塚原 徹也
  • Organizer: 第79回日本脳神経外科学会総会
• [Presentation] In vivo Optical Coherence Tomography of cerebral microvessels in medaka (2020)
  • Author(s): Takashi Suzuki, Tomohiro Ueno, Naoya Oishi, Hidenao Fukuyama
  • Organizer: SPIE Photonics West BIOS
  • Int'l Joint Research
• [Presentation] Gender Difference in End- of Life Caregiving (2019)
  • Author(s): Kazuko Hiyoshi, Carl Becker, Hidenao Fukuyama, Naoya Oishi
  • Organizer: WONCA 2019
  • Int'l Joint Research
• [Presentation] Predicting clinical outcomes of acute ischemic stroke due to large vessel occlusion: The approach to utilize neuroimaging data with deep learning (2019)
  • Author(s): Hidehisa Nishi, Naoya Oishi, Akira Ishii, Isao Ono, Takenori Ogura, Tadashi Sunohara, Hideo Chihara, Ryu Fukumitsu, Masakazu Okawa, Norikazu Yamana, Hirotoshi Imamura, Nobutake Sadamasa, Taketo Hatano, Ichiro Nakahara, Nobuyuki Sakai,Susumu Miyamoto
  • Organizer: East Asian Conference on Neurointervention (EACoN) 2019
  • Int'l Joint Research
• [Presentation] Psychological resilience and functional connectivity change of the default mode network (2019)
  • Author(s): Takashi Miyagi, Naoya Oishi, Kei Kobayashi, Tsukasa Ueno, Sayaka Yoshimura, Toshiya Murai, Hironobu Fujiwara
  • Organizer: ISSID 2019
  • Int'l Joint Research
• [Presentation] The association between non-clinical internet use and functional connectivity of the alerting network in attention system (2019)
  • Author(s): Kei Kobayashi, Hironobu Fujiwara, Naoya Oishi, Sayaka Yoshimura, Tsukasa Ueno, Takashi Miyagi, Toshiya Murai
  • Organizer: ISSID 2019
  • Int'l Joint Research
• [Presentation] Autistic Traits Are Associated with the Functional Connectivity of Between-But Not Within- Attention Systems in the General Population (2019)
  • Author(s): Sayaka Yoshimura, Hironobu Fujiwara, Kei Kobayashi, Tsukasa Ueno, Takashi Miyagi, Naoya Oishi, Toshiya Murai
  • Organizer: ISSID 2019
  • Int'l Joint Research
• [Presentation] Contribution of the orbitofrontal cortex to inference based on specific stimulus-reward relationships (2019)
  • Author(s): Masaaki Ogawa, Seiya Ishino, Kota Tokuoka, Tadashi Isa, Brian D. Allen, Amy S. Chuong , Edward S. Boyden, Naoya Oishi, Im Snaghun, Takeshi Yamada
  • Organizer: Society for Neuroscience 2019
  • Int'l Joint Research
• [Presentation] Predicting clinical outcomes of acute ischemic stroke due to large vessel occlusion: The approach to utilize high-dimensional neuroimaging data as a whole with deep learning (2019)
  • Author(s): Hidehisa Nishi, Naoya Oishi, Akira Ishii, Isao Ono, Takehiro Katano, Yu Abekura, Hideo Chihara, Yukihiro Yamao, Masakazu Okawa, Takayuki Kikuchi, Taketo Hatano, Ichiro Nakahara, Susumu Miyamoto
  • Organizer: International Stroke Conference 2019
  • Int'l Joint Research
• [Presentation] The association between autistic traits and internet use in attention networks: a resting state fMRI study. (2018)
  • Author(s): Hironobu Fujiwara, Sayaka Yoshimura, Kei Kobayashi, Tsukasa Ueno, Naoya Oishi, Toshiya Murai
  • Organizer: IACAPAP 2018
  • Int'l Joint Research
• [Presentation] Autistic traits in general population are associated with functional connectivity among the brain regions related to the attentional orienting network (2018)
  • Author(s): Sayaka Yoshimura, Hironobu Fujiwara, Kei Kobayashi, Tsukasa Ueno, Naoya Oishi, Toshiya Murai
  • Organizer: IACAPAP 2018
  • Int'l Joint Research
• [Presentation] Near-infrared hyperspectral imaging in biomedicine (2018)
  • Author(s): Naoya Oishi
  • Organizer: International Conference on Complex Medical Engineering 2018
  • Int'l Joint Research / Invited
• [Presentation] Visualization of microvessels in medaka brain using optical coherence tomography (2018)
  • Author(s): Takashi Suzuki, Tomohiro Ueno, Naoya Oishi and Hidenao Fukuyama
  • Organizer: International Conference on Complex Medical Engineering 2018
  • Int'l Joint Research / Invited
• [Presentation] Brainstem atrophy and cognitive impairment in the chronic phase and clinical severity in the acute phase in diffuse axonal injury (2018)
  • Author(s): Gaku Fujimoto, Shiho Ubukata, Taro Aso, Naoya Oishi, Genichi Sugihara, Toshiya Murai, Keita Ueda
  • Organizer: WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018
  • Int'l Joint Research
• [Presentation] Single-prolonged stress brings brain atrophy in visual cortex and thalamus (2018)
  • Author(s): Takanobu Yoshii, Naoya Oishi, Yuki Sakai, Isao Nishimura, Kenichi Matsuda, Shunji Yamada, Kazuya Ikoma, Masaki Tanaka, Jin Narumoto
  • Organizer: WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018
  • Int'l Joint Research
• [Presentation] Network property of gambling disorder (2018)
  • Author(s): Kosuke Tsurumi, Naoya Oishi, Toshiya Murai, Hidehiko Takahashi
  • Organizer: International Society for Biomedical Research on Alcoholism 2018
  • Int'l Joint Research