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Establishment of a Diagnostic Method for Ureteral Cancer Surgical Risk by Multi-parametric Analysis of Preoperative Images and Minimally Invasive Treatment

Research Project

Project/Area Number 18K07724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNagoya City University

Principal Investigator

Nakagawa Motoo  名古屋市立大学, 医薬学総合研究院(医学), 講師 (60590982)

Co-Investigator(Kenkyū-buntansha) 内木 綾  名古屋市立大学, 医薬学総合研究院(医学), 准教授 (20509236)
内木 拓  名古屋市立大学, 医薬学総合研究院(医学), 講師 (50551272)
下平 政史  名古屋市立大学, 医薬学総合研究院(医学), 准教授 (60597821)
小澤 良之  名古屋市立大学, 医薬学総合研究院(医学), 准教授 (90569005)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsデュアルエナジーCT / 造影CT / 膀胱癌 / 尿管癌 / dual energy CT / monoenergetic imaging / monoenergy imaging / 下肢静脈瘤 / デュアルソースCT / 3.0テスラMRI / テクスチャ解析 / 尿管鏡下手術
Outline of Final Research Achievements

Dual energy CT was performed on patients with bladder cancer, and monoenergetic images equivalent to 40 keV were reconstructed from the data of the images. These image data were compared with the image data of normal tube voltage 120 kVp imaging to examine whether there is a difference in the detection ability of bladder cancer. A comparison of the contrast effect of bladder cancer showed that the 40 keV images showed stronger contrast than the conventional 120 kVp images (P<0.01). The 40 keV images were also significantly more sensitive in detecting bladder cancer in subjective diagnostic imaging. These results were published in an English journal (Jpn J Radiol. 2022;40:177-183).

Academic Significance and Societal Importance of the Research Achievements

膀胱癌の発生率は10万人あたり6~15人であり、近年増加傾向にある。膀胱癌の生存率はⅢ期で50%、Ⅳ期で28%であり、早期に発見し、早期に治療を行うことが望ましい。本研究により、Dual energy CTを用いることで造影CTにおける膀胱癌の診断がより正確に行う事ができると明らかになった。この技術を用いることで、膀胱癌を従来よりも早期に診断、治療が行うことができるようになり、膀胱癌の予後を改善することが期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2022 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Usefulness of advanced monoenergetic reconstruction technique in dual-energy computed tomography for detecting bladder cancer2022

    • Author(s)
      Nakagawa M, Naiki T, Naiki-Ito A, Ozawa Y, Shimohira M, Ohnishi M, Shibamoto Y
    • Journal Title

      Japanese Journal of Radiology

      Volume: 40(2) Issue: 2 Pages: 177-183

    • DOI

      10.1007/s11604-021-01195-5

    • NAID

      210000187175

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of the advanced monoenergetic image reconstruction in dual-energy computed tomography for detecting the perforator vein of lower extremity varix.2020

    • Author(s)
      Matsumae Hidekazu
    • Journal Title

      Acta Radiologica Open

      Volume: 9 Issue: 4 Pages: 1-4

    • DOI

      10.1177/2058460120916198

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Utility of advanced monoenergetic reconstruction technique in dual-energy computed tomography for evaluation of the perforator vein of lower extremity varix.2018

    • Author(s)
      Motoo Nakagawa
    • Organizer
      European Congress of Radiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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