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Construction of upper airway model using computational fluid dynamics in children with obstructive sleep apnea

Research Project

Project/Area Number 18K09860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionKagoshima University

Principal Investigator

YAMASAKI Youichi  鹿児島大学, 医歯学域歯学系, 教授 (30200645)

Co-Investigator(Kenkyū-buntansha) 岩崎 智憲  鹿児島大学, 医歯学域歯学系, 准教授 (10264433)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords流体シミュレーション / 小児閉塞性睡眠時無呼吸症候群 / OSAS / 通気障害部位 / 小児 / OSA / 原因部位 / OSAS / 睡眠無呼吸 / 流体解析
Outline of Final Research Achievements

Identifying the primary site of obstructive sleep apnea (OSA) in children is important to determine treatment strategies; however, current methods and the corresponding treatment of children with OSA are inadequate.
This study demonstrated the efficacy of using computed fluid dynamics in identifying the primary site of OSA, which may differ from the site where obstruction is observed. Computed fluid dynamics may, therefore, be useful to determine the treatment of OSA in children.
Furthermore, children with unilateral cleft lip and palate (UCLP) may have nasal obstruction and experience an increased risk of OSA. Nineteen patients (10.7 years) who required rapid maxillary expansion (RME) had cone‐beam computed tomography images taken before and after RME. Nasal airway ventilation parameters were analyzed via computational fluid dynamics.In children with UCLP, increasing the quantity of airflow and CSA on the cleft side by RME substantially improved nasal ventilation.

Academic Significance and Societal Importance of the Research Achievements

小児閉塞性無呼吸症候群 (OSAS)の罹患率は2%前後で、睡眠障害に伴う眠気、体調不良、学業不振、成長障害だけでなく、重症例では高血圧、呼吸不全、心不全を認める。また、ダウン症児ではOSAの罹患率が50%以上とも言われ、呼吸確保のために胡坐で寝る場合もある。この状況の改善には、通気障害部位に応じた治療選択が重要だが、上気道形態は複雑であり正確な原因部位の特定が難しいため、第一選択のアデノイド切除・口蓋扁桃摘出術の治癒率は60%程度と低い。本課題で、最適な治療方法を選択して飛躍的な治癒率改善につながる精度の高い障害部位特定診断モデルを開発し、小児医療に関する実用化の目処が立った。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (6 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Primary site identification in children with obstructive sleep apnea by computational fluid dynamics analysis of the upper airway2020

    • Author(s)
      Yanagisawa-Minami Ayaka、Sugiyama Takeshi、Iwasaki Tomonori、Yamasaki Youichi
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 16 Issue: 3 Pages: 431-439

    • DOI

      10.5664/jcsm.8224

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between pharyngeal airway depth and ventilation condition in mandibular setback surgery: A computational fluid dynamics study2020

    • Author(s)
      Shirazawa Yoshito、Iwasaki Tomonori、Ooi Kazuhiro、Kobayashi Yutaka、Yanagisawa‐Minami Ayaka、Oku Yoichiro、Yokura Anna、Ban Yuusuke、Suga Hokuto、Kawashiri Shuichi、Yamasaki Youichi
    • Journal Title

      Orthodontics & Craniofacial Research

      Volume: 1 Issue: 3 Pages: 1-9

    • DOI

      10.1111/ocr.12371

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How does distraction osteogenesis maxillary expansion (DOME) reduce severity of obstructive sleep apnea?2020

    • Author(s)
      Tomonori Iwasaki, Audrey Yoon, Christian Guilleminault, Youichi Yamasak, Stanley Yung-Chuan Liu
    • Journal Title

      Sleep Breath

      Volume: 24 Issue: 1 Pages: 287-296

    • DOI

      10.1007/s11325-019-01948-7

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Developmental problems concerning children's oral functions, based on a questionnaire administered to dentists and guardians2020

    • Author(s)
      Tamura Fumiyo、Kimoto Shigenari、Yamasaki Youichi、Taguchi Akira、Tanuma Naoyuki、Nakajima Shinya、Negayama Koichi、Kakinoki Yasuaki、Yamada Hiroyuki、Sato Hideo、Sumitomo Masahito
    • Journal Title

      Pediatric Dental Journal

      Volume: 30 Issue: 3 Pages: 167-174

    • DOI

      10.1016/j.pdj.2020.04.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upper airway in children with unilateral cleft lip and palate evaluated with computational fluid dynamics2019

    • Author(s)
      Iwasaki Tomonori、Suga Hokuto、Minami-Yanagisawa Ayaka、Hashiguchi-Sato Makiko、Sato Hideo、Yamamoto Yuushi、Shirazawa Yoshito、Tsujii Toshiya、Kanomi Ryuzo、Yamasaki Youichi
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 156 Issue: 2 Pages: 257-265

    • DOI

      10.1016/j.ajodo.2018.09.013

    • NAID

      120006979185

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the effect of oral-appliance treatment on upper-airway ventilation conditions in obstructive sleep apnea using computational fluid dynamics2019

    • Author(s)
      Suga H, Iwasaki T, Mishima K, Nakano H, Ueyama Y, Yamasaki Y.
    • Journal Title

      Cranio

      Volume: 印刷中 Issue: 3 Pages: 1-9

    • DOI

      10.1080/08869634.2019.1596554

    • NAID

      120006980535

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics2019

    • Author(s)
      Iwasaki Tomonori、Yanagisawa‐Minami Ayaka、Suga Hokuto、Shirazawa Yoshito、Tsujii Toshiya、Yamamoto Yuushi、Ban Yuusuke、Sato‐Hashiguchi Makiko、Sato Hideo、Kanomi Ryuzo、Yamasaki Youichi
    • Journal Title

      Orthodontics & Craniofacial Research

      Volume: - Issue: 3 Pages: 201-207

    • DOI

      10.1111/ocr.12311

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upper airway evaluation of children with unilateral cleft lip and palate using computational fluid dynamics2019

    • Author(s)
      Tomonori Iwasaki, Hokuto Suga, Ayaka Minami-Yanagisawa, Makiko Hashiguchi-Sato, Hideo sato, Yuushi yamamoto, Yoshito Shirazawa, Toshiya Tsujii, Ryuzo Kanomi, Youichi Yamasaki
    • Journal Title

      American Journal of Orthodontics & Dentofacial Orthopedics

      Volume: ー

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] アデノイドによる鼻咽腔通気障害の流体力学的研究2020

    • Author(s)
      與倉杏奈,岩﨑智憲,奥 陽一郎,石丸紘子,佐藤秀夫,嘉ノ海龍三,山﨑要一
    • Organizer
      第58回日本小児歯科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 側面頭部エックス線規格写真と流体解析から口蓋扁桃肥大による通気障害を評価する2020

    • Author(s)
      奥 陽一郎,岩﨑智憲,與倉杏奈,石丸紘子,佐藤秀夫,嘉ノ海龍三,山﨑要一
    • Organizer
      第58回日本小児歯科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 上気道流体シミュレーションを用いた口唇口蓋裂児の鼻腔の上顎急速拡大効果2019

    • Author(s)
      8.岩崎 智憲, 菅 北斗, 柳澤 彩佳, 白澤 良執, 辻井 利弥, 橋口 真紀子, 武元 嘉彦, 嘉ノ海 龍三, 山崎 要一
    • Organizer
      第57回日本小児歯科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 上気道流体シミュレーションを用いた小児OSAの原因部位の特定と閉塞部位との識別2019

    • Author(s)
      10.柳澤 彩佳, 岩崎 智憲, 杉山 剛, 菅 北斗, 白澤 良執, 山本 祐士, 辻井 利弥, 橋口 真紀子, 佐藤 秀夫, 山崎 要一
    • Organizer
      第18回日本睡眠歯科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 上気道流体シミュレーションを用いた 小児OSAの原因部位特定について2018

    • Author(s)
      岩崎智憲 山﨑要一
    • Organizer
      日本睡眠歯科学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 流体解析を用いた小児 OSAS の原因部位特定2018

    • Author(s)
      岩崎智憲 山﨑要一
    • Organizer
      成育歯科医療研究会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 顎顔面部の流体構造連成解析を用いた気道通気状 態解析システム2020

    • Inventor(s)
      岩崎智憲, 山﨑要一
    • Industrial Property Rights Holder
      岩崎智憲, 山﨑要一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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