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Clarification of bactericidal effect using controllable nanostructures

Research Project

Project/Area Number 18K19008
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 28:Nano/micro science and related fields
Research InstitutionKansai University

Principal Investigator

ITO Takeshi  関西大学, システム理工学部, 教授 (50426350)

Co-Investigator(Kenkyū-buntansha) 小嶋 寛明  国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 上席研究員 (00359077)
新宮原 正三  関西大学, システム理工学部, 教授 (10231367)
清水 智弘  関西大学, システム理工学部, 教授 (80581165)
Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsナノ構造 / 抗菌 / 殺菌 / QCM / 経時変化 / 濡れ性 / 微生物付着 / バイオミメティクス
Outline of Final Research Achievements

In order to reveal the antimicrobial mechanism expressed by nanostructures, we controlled the dimensions of the nanostructures and their physicochemical properties to evaluate the effects of these parameters on the antimicrobial properties in this study.
As a result of the research, we developed a technology that could form nanopillars on silicon substrates with setup dimensions, and found the structural features that make them exhibit antibacterial properties. We also found that physicochemical conditions are also important.

Academic Significance and Societal Importance of the Research Achievements

これまでの抗菌剤は、金属系や化学物質が使われてきたが、それらに耐性をもつ薬剤耐性菌が生まれ、それらの菌に感染して亡くなる人の数が増加の一途をたどっている。
本研究から生まれる技術は、物理的な作用により抗菌性を発現するものであるため、薬剤耐性菌を生み出しにくいと考えられている。抗菌性を発現する原因を突き止めることで、効果的な人工材を提供できるものと考えられ、人類の保健衛生に大いに貢献するものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2020 2019 2018 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Adhesion and Bactericidal Properties of Nanostructured Surfaces Dependent on Bacterial Motility2020

    • Author(s)
      Keisuke Jindai, Kazuki Nakade, Kyosuke Masuda, Takashi Sagawa, Hiroaki Kojima, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito
    • Journal Title

      RSC Advances

      Volume: 10 Issue: 10 Pages: 5673-5680

    • DOI

      10.1039/c9ra08282d

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] クマゼミの翅を模倣した抗菌材料の開発2019

    • Author(s)
      伊藤健
    • Journal Title

      機能性材料

      Volume: 39 Pages: 44-52

    • Related Report
      2019 Research-status Report
  • [Journal Article] Single Cell / real-time imaging of bactericidal effect on the nanostructural surface2019

    • Author(s)
      Keisuke Jindai, Kazuki Nakade, Takashi Sagawa, Horoaki Kojima, Tomohiro Shimizu, Takeshi Ito
    • Journal Title

      Material Today: Proceedings

      Volume: 7 Pages: 492-496

    • Related Report
      2018 Research-status Report
  • [Journal Article] Adhesion and Bactericidal Properties of a Wettability-Controlled Artificial Nanostructure2018

    • Author(s)
      Nakade Kazuki、Jindai Keisuke、Sagawa Takashi、Kojima Hiroaki、Shimizu Tomohiro、Shingubara Shoso、Ito Takeshi
    • Journal Title

      ACS Applied Nano Materials

      Volume: 1 Issue: 10 Pages: 5736-5741

    • DOI

      10.1021/acsanm.8b01340

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Bactericidal effect on the nanostructural surface: mimicking the cicada wing2019

    • Author(s)
      T. Ito, K. Nakade, K. Jindai, T. Sagawa, H. Kojima, T. Shimizu, S. Shingubara
    • Organizer
      Biomimetics in bioengineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Estimation of bacteria death on the nanostructured surface using electrochemical impedance spectroscopy2019

    • Author(s)
      T. Ito, K. Masuda, K. Jindai, H. Kojima, I. Yamashita, T. Shimizu, S. Shingubara
    • Organizer
      IEEE Nano
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of adhesion and deformation of E. coli on the 3D nanostructural electrode using electrochemical impedance spectroscopy2019

    • Author(s)
      T. Ito, K. Masuda, K. Jindai, H. Kojima, I. Yamashita, T. Shimizu, S. Shingubara
    • Organizer
      M&Be 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノ構造における抗菌メカニズム解明を目指した微小空間での電気化学インピーダンス測定2019

    • Author(s)
      増田恭介、神代啓輔、藤野優佑、小嶋寛明、山下一郎、清水智弘、新宮原正三、伊藤健
    • Organizer
      第80回応用物理学会秋季講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] ナノ構造が発現する抗菌作用のリアルタイム観察の試み2019

    • Author(s)
      神代啓輔、増田恭介、富成征弘、田中秀吉、小嶋寛明、清水智弘、新宮原正三、伊藤健
    • Organizer
      第80回応用物理学会秋季講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Time-lapse imaging of bactericidal effect on nanostructural surface2019

    • Author(s)
      Takeshi Ito, Kazuki Nakade, Keisuke Jindai, Takashi Sagawa, Hiroaki Kojima, Tomohiro Shimizu, Shoso Shingubara
    • Organizer
      SPIE Smart Structures
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノ構造が発現する抗菌作用の解明に向けた取り組み2018

    • Author(s)
      伊藤健
    • Organizer
      長崎大学化学・物質工学セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ナノ構造が発現する抗菌作用に付着力が及ぼす影響2018

    • Author(s)
      中出一輝、神代啓輔、佐川貴志、小嶋寛明、新宮原正三、伊藤健
    • Organizer
      第79回応用物理学会秋季講演会
    • Related Report
      2018 Research-status Report
  • [Book] 天然系抗菌・防カビ剤の開発と応用2019

    • Author(s)
      伊藤健 (坂上吉一監修)
    • Total Pages
      232
    • Publisher
      CMC出版
    • ISBN
      9784781312606
    • Related Report
      2019 Research-status Report
  • [Remarks] ナノ機能物理工学

    • URL

      http://www2.kansai-u.ac.jp/nano/

    • Related Report
      2020 Annual Research Report
  • [Remarks] ナノ機能物理工学

    • URL

      http://www2.kansai-u.ac.jp/nano/index.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 関西大学ナノ機能物理工学研究室

    • URL

      http://www2.kansai-u.ac.jp/nano/index.html

    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 抗菌材料及びこれを備えた抗菌部材2018

    • Inventor(s)
      伊藤、清水、新宮原、中出、神代、佐川、小嶋
    • Industrial Property Rights Holder
      伊藤、清水、新宮原、中出、神代、佐川、小嶋
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-186538
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2022-01-27  

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