|Budget Amount *help
¥113,490,000 (Direct Cost : ¥87,300,000、Indirect Cost : ¥26,190,000)
Fiscal Year 2011 : ¥21,190,000 (Direct Cost : ¥16,300,000、Indirect Cost : ¥4,890,000)
Fiscal Year 2010 : ¥21,710,000 (Direct Cost : ¥16,700,000、Indirect Cost : ¥5,010,000)
Fiscal Year 2009 : ¥22,880,000 (Direct Cost : ¥17,600,000、Indirect Cost : ¥5,280,000)
Fiscal Year 2008 : ¥22,880,000 (Direct Cost : ¥17,600,000、Indirect Cost : ¥5,280,000)
Fiscal Year 2007 : ¥24,830,000 (Direct Cost : ¥19,100,000、Indirect Cost : ¥5,730,000)
To examine molecular mechanism for generating neuronal diversity and for building neural network formation in the brain, we focused to diverse CNR/protocadherin molecules which express in the brain. In this study, we identified the several cis-elements, and revealed that DNA methylation and CTCF are essential to regulate expression of CNR/protocadherin genes in each neuron. And also we demonstrated that CNR/protocadherin- α molecules are essential to correct neural networkformation in the brain.