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Regulation of synaptic transmission by the scaffolding protein PSD-95

Research Project

Project/Area Number 19300128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKyoto University

Principal Investigator

DOI Tomoko  Kyoto University, 大学院・理学研究科, 准教授 (00397580)

Research Collaborator ISHIKAWA Yasuyuki  奈良先端科学技術大学, 大学院・バイオサイエンス研究科, 助教 (90346320)
TAMURA Hideki  奈良先端科学技術大学, 大学院・バイオサイエンス研究科, 助教 (80437516)
SHIOSAKA Sadao  奈良先端科学技術大学, 大学院・バイオサイエンス研究科, 教授 (90127233)
TAKAO Keizo  自然科学研究機構, 生理学研究所, 特任准教授 (80420397)
MIYAKAWA Tsuyoshi  藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
FUJIYOSHI Yoshinori  京都大学, 大学院・理学研究科, 教授 (80142298)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
KeywordsPDZドメイン / シナプス可塑性 / シナプス後肥厚 / MAGUKファミリー / PSD-95 / 神経科学 / シグナル伝達 / 脳神経疾患 / タンパク質 / タンパク
Research Abstract

The scaffolding molecule PSD-95 at excitatory synapse is composed of three PDZ domains and SH-GK domain. We examined the roles of PDZ1 and PDZ2 binding by using mice that carry mutated PDZ1 and PDZ2. The results suggest that the PDZ binding stabilizes PSD-95 localized at synapses, which allows normal regulation of synaptic transmission via the direct binding of NMDAR and PSD-95.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 2007

All Journal Article (3 results) Presentation (4 results)

  • [Journal Article] シナプス局在から見えるPSD-95ファミリーの機能多様性2010

    • Author(s)
      土井知子
    • Journal Title

      生体の科学 61(5)

      Pages: 492-493

    • Related Report
      2009 Final Research Report
  • [Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007

    • Author(s)
      土井知子
    • Journal Title

      生体の科学 58(2)

      Pages: 119-124

    • Related Report
      2009 Final Research Report
  • [Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007

    • Author(s)
      土井知子
    • Journal Title

      性体の科学 58(2)

      Pages: 119-124

    • Related Report
      2007 Annual Research Report
  • [Presentation] 第33回日本神経科学大会2010

    • Author(s)
      湊原圭一郎、藤吉好則、土井知子
    • Organizer
      Preferable binding of a novel synaptic adhesion molecule, LRRTM2 with SAP102.
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2009 Final Research Report
  • [Presentation] The ligand-binding of PDZ domains play different roles in the synaptic clustering of PSD-95 and SAP1022009

    • Author(s)
      市川昌平, 関達也, 藤吉好則, 土井知子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜国際会議場
    • Year and Date
      2009-12-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 第32回日本分子生物学会年会2009

    • Author(s)
      市川昌平、関達也、藤吉好則、土井知子
    • Organizer
      The ligand-binding of PDZ domains play different roles in the synaptic clustering of PSD-95 and SAP102.
    • Place of Presentation
      横浜国際会議
    • Related Report
      2009 Final Research Report
  • [Presentation] 第82回日本生化学会大会2009

    • Author(s)
      奥田明子、西村章子、藤吉好則、土井知子
    • Organizer
      Characterization of hETBR expressed in E.coli for isolation of thermo-stable mutants.
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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