| Project/Area Number |
19590330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NARUSE Taeko Tokyo Medical and Dental University, 難治疾患研究所, 特任教員 (80422476)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子遺伝学 / NKレセプター / ゲノム多様性 / リガンド多型 / 遺伝子多型 / 遺伝子多型解析 / 自己免疫疾患 / マイクロサテライトマーカー |
|---|
| Research Abstract |
We have investigated genome diversity of ULBP/RAET1 gene family and found that ULBP4 gene was the most polymorphic with 8 single nucleotide polymorphisms in exons and an insertion/deletion and (GT)n repeat polymorphisms in the promoter region. In addition, specific allele of KIR-3DL1 was associated with the resistance to HIV/AIDS. These observations suggested that allelic diversities of NK receptors and ligands lead to the functional difference of NK cells.
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