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Study on alcohol consumption that is recommended to restrict from the viewpoint of prevention of atherosclerotic disease in women

Research Project

Project/Area Number 19590656
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHyogo College of Medicine

Principal Investigator

WAKABAYASHI Ichiro  Hyogo College of Medicine, 医学部, 教授 (70220829)

Co-Investigator(Kenkyū-buntansha) MARUMO Mikio  兵庫医科大学, 医学部, 講師 (40333950)
TAKAHASHI Yuji  兵庫医科大学, 医学部, 非常勤講師 (20292443)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords保健栄養 / 動脈硬化 / 飲酒習慣 / 性差 / 喫煙 / 飲酒 / 女性
Research Abstract

習慣性飲酒により脂質代謝は改善される一方、血圧は上昇する。女性において飲酒の脂質代謝への影響が大きい対象者群では血圧への影響も大きく、これらの作用の程度は各個人でのアルコール感受性によることが示唆された。飲酒の血圧および血中脂質への影響について検討したところ、女性では飲酒による血圧上昇作用が弱い一方、LDL低下作用およびHDL上昇作用は女性でより強かった。これらの結果は男女で飲酒量を調整した群を用いた分析でも変わらなかった。喫煙歴は飲酒と血圧および血中脂質との関係に交絡したが、この交絡作用には男女間で差は見られなかった。したがって男性に比較して女性では飲酒による抗動脈硬化作用がより顕著に出現する可能性が示唆され、適性飲酒量として男性で推奨されているエタノール換算一日20 - 30 ml (またはg) 以下という基準は女性においても適用可能と考えられる。現在推奨されている女性での適正飲酒量(男性の半分量)について見直す必要がある。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (28 results)

All 2009 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Modification of the association between alcohol drinking and non-HDL cholesterol by gender.2009

    • Author(s)
      Wakabayashi I, Groschner K.
    • Journal Title

      Clin Chim Acta 404

      Pages: 154-159

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of body weight on the relationship between alcohol intake and blood pressure.2009

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Alcohol 44

      Pages: 204-210

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of alcohol consumption with blood pressure and serum lipids in Japanese female smokers and nonsmokers.2009

    • Author(s)
      Wakabayashi I、Araki Y.
    • Journal Title

      Gend Med 6

      Pages: 290-299

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of body weight on the relationship between alcohol intake and blood pressure2009

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Alcoholism 44

      Pages: 204-210

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of the association between alcohol drinking and non-HDL cholesterol by gender2009

    • Author(s)
      Wakabayashi I, Groschner K.
    • Journal Title

      Clin Chim Acta (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships among alcohol drinking, blood pressure and serum cholesterol in healthy young women.2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Clin Chim Acta 338

      Pages: 192-195

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of alcohol drinking and cigarette smoking with serum lipid levels in healthy middle-aged men.2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Alcohol 43

      Pages: 274-280

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between vascular indexes and atherosclerotic risk factors in patients with type 2 diabetes mellitus2008

    • Author(s)
      Wakabayashi I, Masuda H.
    • Journal Title

      Angiology 59

      Pages: 567-573

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification of the association of alcohol drinking with blood pressure by cigarette smoking.2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Blood Press 17

      Pages: 87-93

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of gender on the association of alcohol drinking with blood pressure.2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Am J Hypertens 21

      Pages: 1310-1317

    • Related Report
      2008 Final Research Report
  • [Journal Article] 都道府県別の職域定期健康診断有所見率と脳心血管疾患死亡率との関連性2008

    • Author(s)
      若林一郎
    • Journal Title

      厚生の指標 55

      Pages: 1-6

    • NAID

      40015961650

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of gender on the association of alcohol drinking with blood pressure2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Am J Hypertens 21

      Pages: 1310-1317

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood HDL cholesterol levels influence association of alcohol intake with blood pressure in young men but not in middle-aged men2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Clin Exp Res 31

      Pages: 1552-1557

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships among alcohol drinking,blood pressure and serum cholesterol in healthy voune women2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Clin Chim Acta 388

      Pages: 192-195

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of alcohol drinking and cigarette smoking with serum lipgd levels in healthy middle-aged men2008

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Alcohol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood HDL cholesterol levels influence association of alcohol intake with blood pressure in young men but not in middle-aged men.2007

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Clin Exp Res 31

      Pages: 1552-1557

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] COX-2と循環器疾患2007

    • Author(s)
      高橋裕二, 若林一郎
    • Journal Title

      循環制御 28

      Pages: 115-119

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of gender and age on relationships between alcohol drinking and atheroclerotic risk factors.

    • Author(s)
      Wakabayashi I、Araki Y.
    • Journal Title

      Alcohol Clin Exp Res in press

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 血小板の凝集及びカルシウム流入機構へのアルコールの作用2008

    • Author(s)
      丸茂幹雄, 若林一郎
    • Organizer
      第28回アルコール医学生物学研究会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血栓予防検査医学の創出.インピーダンス法による内臓脂肪面積測定の血栓傾向診断における臨床的有用性2008

    • Author(s)
      末廣謙, 内田景博, 丸茂幹雄, 若林一郎
    • Organizer
      第31回日本血栓止血学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] LOX-1が認識する酸化LDL測定の有用性に関する検討2008

    • Author(s)
      内田景博, 末廣謙, 中西守, 沢村達也, 松田治男, 若林一郎
    • Organizer
      第31回日本血栓止血学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 血小板の凝集及びカルシウム流入機構へのアルコールの作用2008

    • Author(s)
      丸茂幹雄, 若林一郎
    • Organizer
      平成20年度アルコール・薬物依存関連合同学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 飲酒習慣と動脈硬化2007

    • Author(s)
      若林一郎
    • Organizer
      第3回西日本血管・機能研究会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-11
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 血小板の凝集及びカルシウム流入機構へのアルコールの異なる作用2007

    • Author(s)
      丸茂幹雄, 若林一郎
    • Organizer
      第30回日本血栓止血学会
    • Place of Presentation
      三重
    • Related Report
      2008 Final Research Report
  • [Presentation] 血栓傾向評価におけるインピーダンス法による体成分分析装置を用いた内臓脂肪面積測定の有用性2007

    • Author(s)
      末廣謙, 若林一郎, 丸茂幹雄, 内田景博、垣下榮三
    • Organizer
      第30回日本血栓止血学会
    • Place of Presentation
      三重
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢によるメタボリックシンドローム発症に関する縦断的検討2007

    • Author(s)
      末廣謙, 若林一郎, 末廣美津子, 垣下榮三
    • Organizer
      第49回日本老年医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Book] アルコールと医学生物学Vol.282009

    • Author(s)
      丸茂幹雄, 丸茂久美子, 若林一郎
    • Publisher
      東洋出版
    • Related Report
      2008 Final Research Report
  • [Book] アルコールと医学生物学Vol. 282009

    • Author(s)
      丸茂幹雄, 丸茂久美子, 若林一郎
    • Total Pages
      147
    • Publisher
      東洋書店
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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