Study on the mechanism of heat stroke (Role of bacterial translocation on the multi organ failure after heat stroke)

Research Project

Project/Area Number	19590686
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Legal medicine
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	KITA Toshiro University of Occupational and Environmental Health, Japan, 医学部, 准教授 (00131912)
Co-Investigator(Kenkyū-buntansha)	TANAKA Toshiko 産業医科大学, 医学部, 講師 (80141745)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	ショック / 熱中症 / LPS / MAPK / 多臓器不全 / 肝臓 / shock / Heatstroke / heart / FR167653 / Shock / Heat stroke / Liver / bacteria / translocation
Research Abstract	We approach the study on the mechanism of heat stroke. Our quantitative bacterial culture data demonstrated that viable bacteria reached the remote organs after heat stroke. This study provides evidence for the hypothesis that the MAPK pathway controls inflammatory mediators, and we identified the pathophysiologic role of LPS in the development of organ failure after heat stroke.

Report

(4 results)