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Molecular basis for sociality associated with gene environmental interaction mechanism

Research Project

Project/Area Number 19591388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YOKOYAMA Chihiro  The Institute of Physical and Chemical Research, 分子プローブ機能評価研究チーム, 研究員 (90264754)

Co-Investigator(Kenkyū-buntansha) 村山 美穂  岐阜大学, 応用生物学部, 助教授 (60293552)
田原 強  独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (20419708)
尾上 浩隆  独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
Co-Investigator(Renkei-kenkyūsha) MURAYAMA Miho  岐阜大学, 応用生物学部, 助教授 (60293552)
TAHARA Tsuyoshi  独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (20419708)
ONOE Hirotaka  独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords養育環境 / 社会性 / 分子イメージング / セロトニン / バソプレシン / コモンマーモセット / 遺伝子多型 / PET / 脳分子イメージング / 個体間コミュニケーション / microPET / 親子分離 / 利他的行動
Research Abstract

In order to clarify molecular bases for sociality associated with gene-environmental interaction mechanism, we examined the relationship between social behavior and genetic polymorphism or in vivo functional brain imaging revealed by positron emission tomography (PET) in adult common marmosets. We found specific associations for genetic and regional neurochemical aspects with social behavior of individual animals. In addition to that, we revealed the effects of early social deprivation on social behavior associated with these functional molecules.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (27 results) Remarks (2 results)

  • [Journal Article] Mapping of serotonin transporters by positron emission tomography with [(11)C]DASB in conscious common marmosets: Comparison with rhesus monkeys.2010

    • Author(s)
      Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H.
    • Journal Title

      Synapse. (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys.2009

    • Author(s)
      Aizawa K, Ageyama N, Yokoyama C, Hisatsune T.
    • Journal Title

      Exp Anim. 58(4)

      Pages: 403-407

    • NAID

      130000122247

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys2009

    • Author(s)
      Aizawa K
    • Journal Title

      Exp Anim 58

      Pages: 403-407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of rat medial prefrontal cortex lesions on olfactory serial reversal and delayed alternation tasks.2008

    • Author(s)
      Kinoshita S, Yokoyama C, Masaki D, Yamashita T, Tsuchida H, Nakatomi Y, Fukui K.
    • Journal Title

      Neurosci Res. 60(2)

      Pages: 213-218

    • NAID

      10031136222

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonergic mediation of the antidepressant-like effect of the green leaves odor in mice.2008

    • Author(s)
      Nakatomi Y, Yokoyama C, Kinoshita S, Masaki D, Tsuchida H, Onoe H, Yoshimoto K, Fukui K.
    • Journal Title

      Neurosci Lett. 436(2)

      Pages: 167-170

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonergic mediation of the antidepressant-like effect of the green leaves odor in mice2008

    • Author(s)
      Nakatomi Y
    • Journal Title

      Neuroscience Letters 436

      Pages: 167-170

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of rat medial prefrontal cortex lesions on olfactory serial reversal and delayed alternation tasks.2008

    • Author(s)
      Kinoshita S
    • Journal Title

      Neuroscience Research 60

      Pages: 213-218

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping of serotonin transporters by positron emission tomography with[^<11>C]DASB in conscious common marmosets : comparison with rhesus monkeys

    • Author(s)
      Yokoyama C
    • Journal Title

      Synapse (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Brain serotonin transporter functionality associated with traits of social behaviors in the common marmoset2009

    • Author(s)
      Yokoyama C, Kawasaki A, Onoe K, Nagata H, Doi H, Onoe H
    • Organizer
      PET imaging with [(11)C]DASB Society for neuroscience (SFN2009)
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Brain serotonin transporter functionality associated with traits of social behaviors in the common marmoset : PET imaging with[^<11>C]DASB2009

    • Author(s)
      横山ちひろ
    • Organizer
      39th Annual Meeting of the Society for Neuroscience(Neuroscience2009)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 無麻酔下コモンマーモセットの[(11)C]DASBによるPETイメージング―アカゲザルとの比較―2009

    • Author(s)
      横山ちひろ, 山中創, 尾上嘉代, 川崎章弘, 長田浩子, 白神恵子, 土居久志, 和田康弘, 渡辺恭良, 尾上浩隆
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋日本
    • Year and Date
      2009-09-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 無麻酔下コモンマーモセットの[^<11>C]DASBによるPETイメージング―アカゲザルとの比較―2009

    • Author(s)
      横山ちひろ
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 共同繁殖種コモンマーモセットの子育て期前後における父親の体重変化2009

    • Author(s)
      立田委久子, 沓掛展之, 川崎章弘, 横山ちひろ, 尾上浩隆, 長谷川眞理子
    • Organizer
      日本霊長類学会第25回学術大会
    • Place of Presentation
      各務原市日本
    • Year and Date
      2009-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] コモンマーモセットの対面テストにおける行動特性2009

    • Author(s)
      横山ちひろ, 川崎章弘, 井上-村山美穂, 洪京元, 加藤和実, 尾上浩隆
    • Organizer
      日本霊長類学会第25回学術大会
    • Place of Presentation
      各務原日本
    • Year and Date
      2009-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] コモンマーモセットの対面テストにおける行動特性2009

    • Author(s)
      横山ちひろ
    • Organizer
      日本霊長類学会第25回学術大会
    • Place of Presentation
      中部学院大学(各務原)
    • Year and Date
      2009-07-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小動物用PETを用いたマカクサルおよびマーモセット脳における[(11)C]DASB結合能2009

    • Author(s)
      山中創, 横山ちひろ, 尾上浩隆, 長田浩子, 土居久志, 渡辺恭良, 尾上嘉代
    • Organizer
      第4回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      東京日本
    • Year and Date
      2009-05-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 小動物用PETを用いたマカクサルおよびマーモセット脳における[^<11>C]DASB結合2009

    • Author(s)
      山中創
    • Organizer
      第4回日本分子イメージング学会総会学術集会
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] コモンマーモセットの社会行動の特性分子イメージング研究シンポジウム20082008

    • Author(s)
      横山ちひろ, 川崎章弘, 尾上浩隆
    • Organizer
      飛躍を迎えた創薬・疾患診断研究
    • Place of Presentation
      神戸日本
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional brain mapping in transverse patterning task2008

    • Author(s)
      Yamamoto S, Tsukada H, Yokoyama C, Watanabe Y, Onoe H
    • Organizer
      PET study with conscious monkeys 38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2008-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Characteristics of behavior and vocalization during a social2008

    • Author(s)
      Yokoyama C, Kawasaki A, Onoe H
    • Organizer
      challenge in common marmosets 38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2008-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] マーモセット脳のPET「脳科学研究戦略推進プログラム」2008

    • Author(s)
      横山ちひろ
    • Organizer
      課題C分科会
    • Place of Presentation
      京都日本
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] [(11)C]DASBを用いた無麻酔下マーモセット脳におけるセロトニントランスポーターのPETイメージング2008

    • Author(s)
      横山ちひろ, 川崎章弘, 尾上嘉代, 長田浩子, 畑中恵子, 土居久志, 尾上浩隆
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山日本
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivo brain imaging of serotonin and dopamine transporters by microPET with conscious mice2008

    • Author(s)
      Onoe H, Mizuma H, Shukuri M, Yokoyama C, Yamanaka H, Kawasaki T, Onoe K, Wada Y, Doi H, Nagata H, Suzuki M, Watanabe Y
    • Organizer
      marmosets, and macaque monkeys 2008 World Molecular Imaging Congress Nice France
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] H2(15)O-PET study of motor control network activated by the deep brain stimulation of the subthalamic nucleus in chronic2008

    • Author(s)
      Fang X, Sugiyama K, Akamine S, Nanba H, Yokoyama C, Shukuri M, Mizuma H, Magata Y, Umemura K, Hokamura K, Yamaguchi H, Tsukada H, Onoe H
    • Organizer
      Parkinsonian monkey model 2008 World Molecular Imaging Congress Nice France
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Anabolic-androgenic steroid increases [(11)C]vorozole binding to aromatase in neurons of the hypothalamus in rat and rhesus monkey.2008

    • Author(s)
      Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
    • Organizer
      2008 World Molecular Imaging Congress Nice France
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Genotype dependent antidepressant-like effect of green odor in mice2008

    • Author(s)
      Nakatomi Y, Yokoyama C, Kinoshita S, Masaki D, Tsuchida H, Onoe H, Yoshimoto K, Fukui K
    • Organizer
      International Conference on Fatigue Science 2008
    • Place of Presentation
      Okinawa Japan
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] セロトニン2C受容体と自発アルコール摂取行動2008

    • Author(s)
      吉本寛司, 田中雅樹, 渡邊義久, 横山ちひろ, 西村陽, 坂部昌明, 加藤英明, 上田秀一
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京日本
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 学習能力低減老齢カニクイザルの海馬歯状回における神経幹/前駆細胞数の保存2008

    • Author(s)
      相澤憲, 揚山直英, 横山ちひろ, 寺尾恵治, 久恒辰博
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京日本
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 早期養育環境がコモンマーモセットの音声行動へ及ぼす影響2008

    • Author(s)
      横山ちひろ, 川崎章弘, 尾上浩隆
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京日本
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report
  • [Presentation]2008

    • Author(s)
      高橋佳代, 尾上嘉代, 土居久志, 長田浩子, 山岸玄, 細谷孝充, 田村泰久, 和田康弘, 山中創, 横山ちひろ, 高島忠之, Bergstrom Mats, 尾上浩隆, Langstrom Bengt, 渡辺恭良
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京日本
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 分子イメージングによる神経変性疾患に対する創薬戦略2008

    • Author(s)
      渡辺恭良, 尾上浩隆, 鈴木正昭, 安宅鈴香, 吉岡英斗, 石井英樹, 伊集院良祐, 土居久志, 高橋佳代, 長田浩子, 横山ちひろ, 中江崇敬, 渡辺由美子, 水間広, 徳田景子, 尾上嘉代, 田村泰久, 崔翼龍, 片岡洋祐, 林中恵美, 和田康弘
    • Organizer
      第3回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      さいたま日本
    • Year and Date
      2008-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] MPTPサルにおける視床下核脳深部電気刺激のfood reaching testを用いた評価2008

    • Author(s)
      方欣, 杉山憲嗣, 赤嶺壮一, 難波宏樹, 横山ちひろ, 宿里充穗, 水間広, 塚田秀夫, 尾上浩隆
    • Organizer
      第47回日本定位・機能神経外科学会合同教育セミナー
    • Place of Presentation
      浜松市日本
    • Year and Date
      2008-01-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑の香りがもつ抗うつ薬様効果2007

    • Author(s)
      中富康仁, 横山ちひろ, 木下清二朗, 正木大貴, 土田英人, 尾上浩隆, 吉本寛司, 福居顯二
    • Organizer
      第30回日本神経科学大会第50回日本神経化学学会大会第17回日本神経回路学会大会
    • Place of Presentation
      横浜日本
    • Year and Date
      2007-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 学習機能減衰を示す老齢カニクイザルの海馬歯状回における新生ニューロン数の減少2007

    • Author(s)
      相澤憲, 揚山直英, 横山ちひろ, 寺尾恵治, 久恒辰博
    • Organizer
      第30回日本神経科学大会第50回日本神経化学学会大会第17回日本神経回路学会大会
    • Place of Presentation
      横浜日本
    • Year and Date
      2007-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] マカクサルを用いたPET脳賦活実験による神経ネットワークの解析2007

    • Author(s)
      横山ちひろ
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京日本
    • Year and Date
      2007-06-02
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.cmis.riken.jp/image/news/seika_yokoyama.pdf

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.cmis.riken.jp/image/index/seika_yokoyama.pdf

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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