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An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

Research Project

Project/Area Number 19591390
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

YAMADA Misa  National Center of Neurology and Psychiatry, 老人精神保健部, 科研費研究員 (10384182)

Co-Investigator(Kenkyū-buntansha) YAMADA Mitsuhiko  国立精神・神経センター精神保健研究所, 老人精神保健部, 部長 (60240040)
TAKAHASHI Kou  国立精神・神経センター精神保健研究所, 老人精神保健部, 外来研究員 (20415582)
丸山 良亮  国立精神・神経センター, 精神保健研究所・老人精神保健部, 研究員 (70421831)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords精神薬理学 / 抗うつ薬 / 転写因子 / 大脳皮質初代培養神経細胞 / 網羅的探索
Research Abstract

In the present study, we identified the gene, plasticity-related gene 1 (Prg1), targeted by a transcription factor Math2 which is an antidepressant related gene. Our results may support the hypothesis that Math2-Prg1 mediated plastic changes of nervous system in frontal cortex are involved with therapeutic action of antidepressants.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Yamada M.
    • Journal Title

      J. Mental Health 55

      Pages: 103-109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain2009

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Yamada M.
    • Journal Title

      J.Mental Health 55

      Pages: 103-109

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y., Tobe, T., Yamada, M.
    • Journal Title

      J. Neurochem 106

      Pages: 2375-2384

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math22008

    • Author(s)
      Yamada M, Shida Y, Takahashi K, Tanioka T, Nakano Y, Tobe T, Yamada M.
    • Journal Title

      J. Neurochem 106

      Pages: 2375-2384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Methylphenidate on the Hyperemotional Behavior in OlfactoryBulbectomized Mice by Using the Hole-Board Test2007

    • Author(s)
      Kamei J, Hirose N, Oka T, Miy ata S, Saitoh A, Yamada M
    • Journal Title

      J Phannacol Sci 103

      Pages: 175-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TREK-1カリウムチャネル:抗うつ薬創出の新たなターゲット2007

    • Author(s)
      丸山 良亮, 山田 光彦
    • Journal Title

      日本神経精神薬理学雑誌 27

      Pages: 147-151

    • NAID

      10023964462

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007

    • Author(s)
      志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
    • Organizer
      第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
    • Place of Presentation
      パシフィコ横浜, 神奈川
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子が制御する下流遺伝子の探索2007

    • Author(s)
      志田 美子, 高橋 弘, 山田 美佐, 中野 泰子, 戸部 敞, 山田 光彦
    • Organizer
      第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

    • Author(s)
      Yamada, M., Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y, Tobe, T.
    • Organizer
      The 1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      京都国際会議場Kyoto, Japan
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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