• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

Research Project

  • PDF
Project/Area Number 19591390
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

YAMADA Misa  National Center of Neurology and Psychiatry, 老人精神保健部, 科研費研究員 (10384182)

Co-Investigator(Kenkyū-buntansha) YAMADA Mitsuhiko  国立精神・神経センター精神保健研究所, 老人精神保健部, 部長 (60240040)
TAKAHASHI Kou  国立精神・神経センター精神保健研究所, 老人精神保健部, 外来研究員 (20415582)
Project Period (FY) 2007 – 2009
Keywords精神薬理学 / 抗うつ薬 / 転写因子 / 大脳皮質初代培養神経細胞 / 網羅的探索
Research Abstract

In the present study, we identified the gene, plasticity-related gene 1 (Prg1), targeted by a transcription factor Math2 which is an antidepressant related gene. Our results may support the hypothesis that Math2-Prg1 mediated plastic changes of nervous system in frontal cortex are involved with therapeutic action of antidepressants.

  • Research Products

    (4 results)

All 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Yamada M.
    • Journal Title

      J. Mental Health 55

      Pages: 103-109

    • Peer Reviewed
  • [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y., Tobe, T., Yamada, M.
    • Journal Title

      J. Neurochem 106

      Pages: 2375-2384

    • Peer Reviewed
  • [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007

    • Author(s)
      志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
    • Organizer
      第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
    • Place of Presentation
      パシフィコ横浜, 神奈川
    • Year and Date
      20071211-20071215
  • [Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

    • Author(s)
      Yamada, M., Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y, Tobe, T.
    • Organizer
      The 1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      京都国際会議場Kyoto, Japan
    • Year and Date
      00001113-00001114

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi