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A novel strategy of prevention of gastric cancer recurrence-prediction of effect of chemotherapy for potential recurrence after curative operation-

Research Project

Project/Area Number 19591569
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKanazawa Medical University

Principal Investigator

KOSAKA Takeo  Kanazawa Medical University, 医学部, 教授 (30186663)

Co-Investigator(Kenkyū-buntansha) 菅谷 純一  金沢医科大学, 医学部, 助教 (20298342)
黒田 雅利  金沢医科大学, 医学部, 助教 (90424902)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords胃癌 / 化学療法 / 予後因子 / 5-FU代謝酵素
Research Abstract

Multivariate analysis identified positive lymph node metastasis, low total cholesterol level, a small number of lymphocytes, positive venous invasion, and elevated serum CA19-9 level as independent prognostic factors in curatively resected gastric cancer patients. It should be considered to administer anti-cancer drugs in such cases. In addition, it may be useful to evaluate enzyme activity regarding 5-FU metabolism in predicting the effect of anticancer drugs and prognosis of gastric cancer patient.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2010 2008 2007

All Presentation (14 results)

  • [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer-A short communication. ESMO conference2010

    • Author(s)
      小坂健夫, et al
    • Organizer
      12th World Congress on Gastrointestinal Cancer
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer-A short communication2010

    • Author(s)
      Takeo Kosaka
    • Organizer
      ESMO conference : 12th World Congress on Gastrointestinal Cancer
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prognostic significance of nutritional factors in curatively resected gastric cancer patients.2010

    • Author(s)
      小坂健夫, et al
    • Organizer
      21st Meeting of the European Association for Cancer Research
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2010-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Prognostic significance of nutritional factors in curatively resected gastric cancer patients2010

    • Author(s)
      Takeo Kosaka
    • Organizer
      21st Meeting of the European Association for Cancer Research
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2010-06-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] TS-1+CDDP療法は、腹膜播種陽性胃癌の術前の化学療法として妥当か?2010

    • Author(s)
      木南伸一、小坂健夫、他
    • Organizer
      第35回日本外科系連合学会学術集会
    • Place of Presentation
      浦安市
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] TS-1+CDDP療法は、腹膜播種陽性胃癌の術前の化学療法として妥当か2010

    • Author(s)
      木南伸一
    • Organizer
      第35回日本外科系連合学会学術集会
    • Place of Presentation
      浦安市
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer.2010

    • Author(s)
      小坂健夫, et al
    • Organizer
      The 17th Czech-Japan Surgical Symposium
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2010-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer2010

    • Author(s)
      Takeo Kosaka
    • Organizer
      The 17th Czech-Japan Surgical Symposium
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] StageIV胃がんに対するTS-1+CDDP療法の、術前化学療法としての有用性と問題点、さらに外科治療の役割2010

    • Author(s)
      木南伸一、小坂健夫、他
    • Organizer
      第82回日本胃癌学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-03-04
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] StageIV胃がんに対するTS-1+CDDP療法の、術前化学療法としての有用性と問題点、さらに外科治療の役割2010

    • Author(s)
      木南伸一
    • Organizer
      第82回日本胃癌学会総会
    • Place of Presentation
      新潟市(朱鷺メッセ新潟コンベンションセンター)
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 深達度と再建法からみた残胃癌治療の個別化2008

    • Author(s)
      小坂健夫、他
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 深達度と再建法からみた残胃癌治療の個別化2008

    • Author(s)
      小坂健夫, 他
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-05-16
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 再発リスク予測に基づいた術後補助治療とフォローアップ2008

    • Author(s)
      小坂健夫、他
    • Organizer
      第80回日本胃癌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-02-28
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report 2007 Annual Research Report
  • [Presentation] 5-FU代謝酵素活性と胃癌進展度および化学療法の効果と予後2007

    • Author(s)
      小坂健夫、他
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2007-10-24
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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