A novel strategy of prevention of gastric cancer recurrence-prediction of effect of chemotherapy for potential recurrence after curative operation-

• Project/Area Number: 19591569
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: KOSAKA Takeo Kanazawa Medical University, 医学部, 教授 (30186663)
• Co-Investigator(Kenkyū-buntansha): 菅谷 純一 金沢医科大学, 医学部, 助教 (20298342) ; 黒田 雅利 金沢医科大学, 医学部, 助教 (90424902)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 胃癌 / 化学療法 / 予後因子 / 5-FU代謝酵素

Research Abstract

Multivariate analysis identified positive lymph node metastasis, low total cholesterol level, a small number of lymphocytes, positive venous invasion, and elevated serum CA19-9 level as independent prognostic factors in curatively resected gastric cancer patients. It should be considered to administer anti-cancer drugs in such cases. In addition, it may be useful to evaluate enzyme activity regarding 5-FU metabolism in predicting the effect of anticancer drugs and prognosis of gastric cancer patient.

Research Products

• [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer-A short communication. ESMO conference (2010)
  • Author(s): 小坂健夫, et al
  • Organizer: 12th World Congress on Gastrointestinal Cancer
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-01
• [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer-A short communication (2010)
  • Author(s): Takeo Kosaka
  • Organizer: ESMO conference : 12th World Congress on Gastrointestinal Cancer
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-01
• [Presentation] Prognostic significance of nutritional factors in curatively resected gastric cancer patients. (2010)
  • Author(s): 小坂健夫, et al
  • Organizer: 21st Meeting of the European Association for Cancer Research
  • Place of Presentation: Oslo, Norway
  • Year and Date: 2010-06-28
• [Presentation] Prognostic significance of nutritional factors in curatively resected gastric cancer patients (2010)
  • Author(s): Takeo Kosaka
  • Organizer: 21st Meeting of the European Association for Cancer Research
  • Place of Presentation: Oslo, Norway
  • Year and Date: 2010-06-28
• [Presentation] TS-1+CDDP療法は、腹膜播種陽性胃癌の術前の化学療法として妥当か? (2010)
  • Author(s): 木南伸一、小坂健夫、他
  • Organizer: 第35回日本外科系連合学会学術集会
  • Place of Presentation: 浦安市
  • Year and Date: 2010-06-17
• [Presentation] TS-1+CDDP療法は、腹膜播種陽性胃癌の術前の化学療法として妥当か (2010)
  • Author(s): 木南伸一
  • Organizer: 第35回日本外科系連合学会学術集会
  • Place of Presentation: 浦安市
  • Year and Date: 2010-06-17
• [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer. (2010)
  • Author(s): 小坂健夫, et al
  • Organizer: The 17th Czech-Japan Surgical Symposium
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2010-06-06
• [Presentation] Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced gastric cancer (2010)
  • Author(s): Takeo Kosaka
  • Organizer: The 17th Czech-Japan Surgical Symposium
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2010-06-06
• [Presentation] StageIV胃がんに対するTS-1+CDDP療法の、術前化学療法としての有用性と問題点、さらに外科治療の役割 (2010)
  • Author(s): 木南伸一、小坂健夫、他
  • Organizer: 第82回日本胃癌学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-03-04
• [Presentation] StageIV胃がんに対するTS-1+CDDP療法の、術前化学療法としての有用性と問題点、さらに外科治療の役割 (2010)
  • Author(s): 木南伸一
  • Organizer: 第82回日本胃癌学会総会
  • Place of Presentation: 新潟市(朱鷺メッセ新潟コンベンションセンター)
  • Year and Date: 2010-03-04
• [Presentation] 深達度と再建法からみた残胃癌治療の個別化 (2008)
  • Author(s): 小坂健夫、他
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-16
• [Presentation] 深達度と再建法からみた残胃癌治療の個別化 (2008)
  • Author(s): 小坂健夫, 他
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-05-16
• [Presentation] 再発リスク予測に基づいた術後補助治療とフォローアップ (2008)
  • Author(s): 小坂健夫、他
  • Organizer: 第80回日本胃癌学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-02-28
• [Presentation] 5-FU代謝酵素活性と胃癌進展度および化学療法の効果と予後 (2007)
  • Author(s): 小坂健夫、他
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2007-10-24