| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Research Abstract |
In order to investigate the possibility that the intraparenchymal arterioles show remodeling based on phenotypic modulation of smooth muscle cells which results in the disorder of cedrebral blood flow autoregulation after subarachnoid hemorrhage, the experimental study using rabbits were performed. After the subarachnoid hemorrhage, cedrebral blood flow autoregulation was disturbed in association with the degree of the remodeling in the arterioles. The remodeling and the disorder of autoregulation could not be improved by intrathecal administration of antisense oligo DNA for several factors related to the pathology of remodeling. On the other hand, administration of several drugs affecting intracellular signaling transduction could improve the remodeling and the disorder of autoregulation.
|
