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Development of minimally invasive cardiac output estimation using expired gas analysis.

Research Project

Project/Area Number 19592097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionSaitama Medical University

Principal Investigator

SAWANO Makoto  Saitama Medical University, 医学部, 准教授 (40242143)

Co-Investigator(Kenkyū-buntansha) 間藤 卓  埼玉医科大学, 医学部, 講師 (90251248)
Co-Investigator(Renkei-kenkyūsha) MATO Takashi  埼玉医科大学, 医学部, 准教授 (90251248)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords呼気分析 / 心拍出量測定 / 低侵襲検査
Research Abstract

Applying carboxyhemoglobin densitometry by breath analysis to low-dose carboxyhemoglobin-dilution method, we developed a minimally invasive method for measuring cardiac output (BA). The objective of this study is to verify accuracy of BA by assessing agreement with Thermo-dilution method (TD), and to clarify whether BA can be accepted as a less invasive replacement of TD. Cardiac outputs were measured simultaneously by BA and TD in 12 ICU patients. The measurements are repeated twice in each patient with interval of 24 hours. Agreement between the measurements by two methods was statistically assessed by Bland-Altman's method. "Limits of Agreement" between cardiac output measurements by BA and TD were -0.26±0.49L/min. "Coefficient of Repeatability" for TD was ±1.00L/min. These results indicate that accuracy of BA is equivalent to or greater than that of TD. As a conclusion, BA may be accepted as less invasive replacement of TD in cardiac output monitoring.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (11 results)

  • [Journal Article] 呼気炭酸ガス分析による極低侵襲心拍出量測定法の開発2009

    • Author(s)
      澤野誠, 間藤卓, 中田一之, 西岡利彦
    • Journal Title

      埼玉医科大学雑誌 Vol.35No.1

      Pages: 65-68

    • Related Report
      2009 Final Research Report
  • [Journal Article] 呼気炭酸ガス分析による極低侵襲心拍出量測定法の開発2009

    • Author(s)
      澤野誠
    • Journal Title

      埼玉医科大学雑誌 35

      Pages: 65-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼気分析による極低侵襲心拍出量測定法の開発2008

    • Author(s)
      澤野誠
    • Journal Title

      呼気生化学の進歩 10

      Pages: 11-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 循環動態モニタリングへの呼気分析の応用 新しい低侵襲測定技術の開発2008

    • Author(s)
      澤野誠
    • Journal Title

      安定同位体と生体ガス:医学応用 1(1)

      Pages: 32-38

    • NAID

      40018999089

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 循環動態モニタリングへの呼気分析の応用…新しい低侵襲測定技術の開発2008

    • Author(s)
      澤野 誠
    • Journal Title

      日本安定同位体・生体ガス医学応用学会誌 1

      Pages: 32-38

    • NAID

      40018999089

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 呼気分析による極低侵襲心拍出量測定法の開発2008

    • Author(s)
      澤野 誠
    • Journal Title

      呼気生化学の進歩 10

      Pages: 11-15

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 呼気分析による極低侵襲心拍出量測定法の開発2008

    • Author(s)
      澤野 誠
    • Journal Title

      呼気病態生化学の進歩 10

      Pages: 11-15

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼気一酸化炭素分析の心拍出量測定への応用 呼気分析は肺動脈カテーテルを超えるか?2007

    • Author(s)
      澤野誠
    • Journal Title

      呼気生化学の進歩 9

      Pages: 23-26

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 呼気分析による極低侵襲心拍出量測定法・・・肺動脈カテーテルによる熱希釈法との比較試験・・・2009

    • Author(s)
      澤野誠, 間藤卓, 堤晴彦
    • Organizer
      第37回日本救急医学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 呼気分析による極低侵襲心拍出量測定法…肺動脈カテーテルによる熱希釈法との比較試験…2009

    • Author(s)
      澤野誠
    • Organizer
      第37回日本救急医学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体における一酸化炭素(CO)ダイナミクス・・・HemeおよびHemoglobinと内因性COとの関わりを中心として(招聘講演)2009

    • Author(s)
      澤野誠
    • Organizer
      第13回酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 生体における一酸化炭素(CO)ダイナミクス…Heme および Hemoglobin と内因性COとの関わりを中心として2009

    • Author(s)
      澤野誠
    • Organizer
      第13回酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下内章人13COをtracerとした内因性COの体内動態に関する基礎的検討2009

    • Author(s)
      澤野誠
    • Organizer
      第5回Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2009-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 下内章人13COをtracerとした内因性CO体内動態における未解明pathwayに関する検討2009

    • Author(s)
      澤野誠
    • Organizer
      第1回日本安定同位体生体ガス医学応用学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Minimally Invasive Cardiac Output Estimation Using Carboxyhaemoglobin Desitometry by Breath-Analysis呼気分析を応用した低侵襲心拍出量測定法の開発2008

    • Author(s)
      澤野 誠
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 呼気分析を応用した極低侵襲心拍出量測定法の開発2008

    • Author(s)
      澤野誠, 間藤卓, 中田一之, 森脇龍太郎, 大森達人, 山口充, 堤晴彦
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Minimally Invasive Cardiac Output Measurement Using Carboxyhaemoglobin Measurement By Breath Analysis2007

    • Author(s)
      Makoto Sawano
    • Organizer
      Breath Analysis Summit 2007
    • Place of Presentation
      Cleveland,USA
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 呼気分析による内因性coの体内動態に関する検討2007

    • Author(s)
      澤野誠
    • Organizer
      第4回hemeoxy genase研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2007-08-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 呼気分析による極低侵襲心拍出量測定法の開発2007

    • Author(s)
      澤野誠
    • Organizer
      第9回日本呼気病態生化学研究会学術大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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