Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responses

• Project/Area Number: 19592168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HASHIGUCHI Masaaki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20372443)
• Co-Investigator(Kenkyū-buntansha): AZUMA Miyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 免疫 / 感染 / 炎症 / 補助シグナル / T細胞 / アレルギー / 破骨細胞

Research Abstract

x補助シグナル分子は細胞間相互作用において正あるいは負に応答を制御することが知られている. 本研究により, これまで詳細な機能が不明であったB7ファミリー分子B7-H3のカウンターレセプターがTremファミリーに属するTrem-like transcript 2(Tlt2, Treml2)であることを同定した. さらに, B7-H3とTlt2の会合はT細胞応答を亢進し, また接触性アレルギーを亢進することを明らかにした.

Research Products

• [Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses (2008)
  • Author(s): Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 105 Pages: 10495-10500
• [Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses (2008)
  • Author(s): Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 10495-10500
  • Peer Reviewed
• [Presentation] Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responses (2008)
  • Author(s): Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
  • Organizer: 日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses (2008)
  • Author(s): Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
  • Organizer: 日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-12
• [Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor (2007)
  • Author(s): Hashiguchi, M., Kobori, H., Ritprajak,P., Piao, J., Azuma, M.
  • Organizer: American Association of Immunologist
  • Place of Presentation: Miami Beach, Florida, USA
  • Year and Date: 2007-05-20
• [Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor (2007)
  • Author(s): M. Hashiguchi, H. Kobori, P, Ritprajak, J. Piao, M. Azuma
  • Organizer: American Association of Immunologist
  • Place of Presentation: Miami Beach, Florida,USA
  • Year and Date: 2007-05-20