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Analyses of physiological role of circadian clock in the ovary

Research Project

Project/Area Number 19599001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHokkaido University

Principal Investigator

NAKAMURA Tomoko  Hokkaido University, 大学院・医学研究科, 特任助教 (30451397)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Atsushi  電気通信大学, 電気通信学部, 助教 (50361829)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,317,872 (Direct Cost: ¥3,782,979、Indirect Cost: ¥534,893)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥497,872 (Direct Cost: ¥382,979、Indirect Cost: ¥114,893)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords概日リズム / 末梢時計 / 中枢時計 / 卵巣 / 黄体形成ホルモン / LHサージ / ルシフェラーゼレポーター / 発情周期
Research Abstract

Current understanding in the field is that the circadian clock in the suprachiasmatic nucleus controls the phase of circadian clock in the peripheral organs. However, the mechanism of the control is remained to be shown. In this study, we used the rat ovary as a model of the peripheral organ, and investigated the potency of LH to control the phase of the circadian clock. When LH level was kept at a constant level in the rat by a pharmacological or surgical method, the amplitude of circadian oscillation was significantly decreased. The result indicates that LH is important to maintain circadian oscillation in the ovary.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2010 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 10 results) Presentation (15 results) Book (5 results)

  • [Journal Article] A circadian egg timer gates ovulation2010

    • Author(s)
      Sellix, M. T., Yoshikawa, T., Menaker, M.
    • Journal Title

      Curr. Biol. 20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A circadian egg timer gates ovulation2010

    • Author(s)
      Sellix, M.T.
    • Journal Title

      Current Biology 20

      Pages: 266-267

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ontogeny of circadian organization in the rat2009

    • Author(s)
      Yoshikawa T., Yamazaki S., Biscoe E. W., Numano R., Gallaspy L. M., Soulsby S., Papadimas E., Pezuk P., Doyle S. E., Tei H., Sakaki Y., Block G. D., Menaker M.
    • Journal Title

      J. Biol. Rhythms 24

      Pages: 55-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The timing of the ovarian circadian clock is regulated by gonadotrophins2009

    • Author(s)
      Yoshikawa T., Sellix M., Pezuk P., Menaker M.
    • Journal Title

      Endocrinology 50

      Pages: 4338-4347

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The timing of the ovarian circadian clock is regulated by gonadotrophins2009

    • Author(s)
      Yoshikawa, T.
    • Journal Title

      Endocrinology 50

      Pages: 4338-4347

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      吉川朋子
    • Journal Title

      光周性の分子生物学(シュプリンガー・ジャパン)

      Pages: 159-168

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Honma S.
    • Journal Title

      Molecular Imaging for Integrated Medical Therapy and Drug Development(Springer)

      Pages: 189-196

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Ontogeny of circadian organization in the rat2009

    • Author(s)
      Yamazaki S.
    • Journal Title

      J. Biol. Rhythms 24

      Pages: 55-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal pathways influence temporal niche2008

    • Author(s)
      Doyle S. E., Yoshikawa T., Hillson H., Menaker M.
    • Journal Title

      Proc. Natl. Acad. Sci. 105

      Pages: 13133-13138

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clock mechanisms for seasonal adaptation : Morning and evening oscillators in the suprachiasmatic nucleus2008

    • Author(s)
      Honma S., Inagaki N., Ono D., Yoshikawa T., Hashimoto S., Honma K.
    • Journal Title

      Sleep and Biological Rhythms 6

      Pages: 84-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体リズムの分子機構2008

    • Author(s)
      吉川朋子・本間さと・本間研一
    • Journal Title

      日本臨床 66(S2)

      Pages: 90-95

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clock mechanisms for seasonal adaptation : Morning and evening oscil lators in the sunrachiasmatic nucleus2008

    • Author(s)
      Honma S.
    • Journal Title

      Sleep and Biological Rhythms 6

      Pages: 84-90

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal pathways influence temporal niche2008

    • Author(s)
      Doyle S. E.
    • Journal Title

      Proc. Natl. Acad. Sci. 105

      Pages: 13133-13138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体リズムの分子機構2008

    • Author(s)
      吉川朋子
    • Journal Title

      日本臨床 66(S2)

      Pages: 90-95

    • Related Report
      2008 Annual Research Report
  • [Presentation] Photoperiodic response of multiple oscillators in mouse SCN2009

    • Author(s)
      吉川朋子
    • Organizer
      第16回日本時間生物学会学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 母子分離中の環境温度が新生ラットの概日リズムに及ぼす影響2009

    • Author(s)
      吉川朋子
    • Organizer
      第80回日本動物学会大会
    • Place of Presentation
      静岡市
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 卵巣に存在する概日時計の位相調節機構の解明2009

    • Author(s)
      吉川朋子
    • Organizer
      第80回日本動物学会大会
    • Place of Presentation
      静岡市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of environmental temperature during maternal deprivation on circadian rhythms of neonatal rats.2009

    • Author(s)
      Yoshikawa T.
    • Organizer
      International Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      札幌市
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of ambient temperature during maternal deprivation on circadian rhythms of neonatal rats.2009

    • Author(s)
      Yoshikawa T.
    • Organizer
      XXXVI International Congress of Physiological Science
    • Place of Presentation
      京都市
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Photoperiodic response of multiple oscillators in mouse SCN2009

    • Author(s)
      吉川朋子・本間さと・本間研一
    • Organizer
      第16回日本時間生物学会学術大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] 卵巣に存在する概日時計の位相調節機構の解明2009

    • Author(s)
      吉川朋子
    • Organizer
      第80回日本動物学会大会
    • Place of Presentation
      グランシップ静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 母子分離中の環境温度が新生ラットの概日リズムに及ぼす影響2009

    • Author(s)
      吉川朋子・松野亜美・山仲勇二郎・西出真也・本間さと・本間研一
    • Organizer
      日本動物学会第80回日本動物学会大会
    • Place of Presentation
      グランシップ静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of environmental temperature during maternal deprivation on circadian rhythms of neonatal rats2009

    • Author(s)
      吉川朋子・松野亜美・山仲勇二郎・西出真也・本間さと・本間研一
    • Organizer
      International Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      札幌 北海道大学
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of ambient temperature during maternal deprivation on circadian rhythms of neonatal rats2009

    • Author(s)
      吉川朋子・松野亜美・山仲勇二郎・西出真也・本間さと・本間研一
    • Organizer
      XXXVI International Congress of Physiological Science
    • Place of Presentation
      京都国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] Phase control of the ovarian circadian clock by the central clock2008

    • Author(s)
      吉川朋子・本間さと・本間研一・Michael Menaker
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2009 Final Research Report
  • [Presentation] Perl-luc oscillations and localizations of neuropeptides in the suprachiasmatic nucleus2007

    • Author(s)
      Tomoko Yoshikawa
    • Organizer
      第14回日本時間生物学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ontogeny of circadian organization in rat2007

    • Author(s)
      Tomoko Yoshikawa
    • Organizer
      2nd World Congress of Chronobiology
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ontogeny of circadian organization inrat2007

    • Author(s)
      吉川朋子・山崎晋・Elizabeth W. Biscoe・沼野利佳・Lauren M. Gallaspy・Stacy Soulsby・Evagelia Papadimas・Pinar Pezuk・Susan Doyle・程肇・榊佳之・Gene D. Block・Michael Menaker
    • Organizer
      2^<nd> World Congress of Chronobiology
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2009 Final Research Report
  • [Presentation] Perl-luc oscillations and localizations of neuropeptides in the suprachiasmatic nucleus2007

    • Author(s)
      吉川朋子・本間さと・本間研一
    • Organizer
      第14回日本時間生物学会学術大会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2009 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamai N., Kuge Y. Eds.) Bioluminescent imaging for assessing heterogeneous cell function in the mammalian central circadian clock2009

    • Author(s)
      Honma S., Yoshikawa T., Nishide S.-H., Ono D., Honma K.-I.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] 視交叉上核と光周性 海老原史樹文 (編) 光周性の分子生物学2009

    • Author(s)
      吉川朋子・本間さと
    • Publisher
      シュプリンガー・ジャパン
    • Related Report
      2009 Final Research Report
  • [Book] Roles of melatonin in photoperiodic gonadal response of birds Experimental Endocrinology and Reproductive Biology (Haldar C., Singaravel M., Pandi-Perumal S. R., Cardinali D. P. Eds.)2008

    • Author(s)
      Yoshikawa T., Iigo M., Okano T., Fukada Y.
    • Publisher
      Science Publishers
    • Related Report
      2009 Final Research Report
  • [Book] Experimental Endocrinology and Reproductive Biology2008

    • Author(s)
      Yoshikawa T.
    • Publisher
      Science Publishers
    • Related Report
      2008 Annual Research Report
  • [Book] Experimental Endocrinology and Reproductive Biology2008

    • Author(s)
      Tomoko Yoshikawa
    • Publisher
      Science Publishers
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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