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Role of astrocyte in synaptic maturation during postnatal developing nucleus tractus solitarius

Research Project

Project/Area Number 19700323
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionMie University (2008-2009)
Jikei University School of Medicine (2007)

Principal Investigator

TASHIRO Yasura  Mie University, 大学院・医学系研究科, 講師 (10398787)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,050,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords神経回路形成 / ニューロン・グリア相互作用 / アストロサイト / シナプス / 延髄 / 孤束核 / 血圧調整 / 神経発達 / ラット / 電顕
Research Abstract

In developing nervous system, unnecessary synapses are eliminated. In the present study, the timing for glial coverage of small cell soma appears to be consistent with the decrease of axosomatic synapses on the small cells. Axosomatic synapses remained in adult stages under pharmacological inhibition of astrocytic processes extension during neonatal stages. These observations indicats that astrocytes could participate actively in regulating the decrease of axosomatic synapses on small cells in the caudal nucleus tractus solitarius during postnatal development.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (10 results)

  • [Journal Article] Postnatal development of axosomatic synapses in the rat nucleus tractus solitaries:dorsal and ventral subnuclei differences2009

    • Author(s)
      Tashiro Y, Okada T, Kawai Y
    • Journal Title

      Neurosci Lett 450(2)

      Pages: 217-220

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal development of axosomatic synapses in the rat nucleus tractus solitarius : dorsal and ventral subnuclei differences2009

    • Author(s)
      Tashiro Y, Okada T, Kawai Y
    • Journal Title

      Neurosceience Letters 450(2)

      Pages: 217-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative and immunohistochemical analysis of neuronal types in the mouse caudal nucleus tractus solitarius: Focus on GABAergic neurons2008

    • Author(s)
      Okada T, Tashiro Y, Kato F, Yanagawa Y, Obata K, Kawai Y
    • Journal Title

      J Chem Neuroanat 35(3)

      Pages: 275-284

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative and immunohistochemical analysis of neuronal types in the mousecaudal nucleus tractus solitarius : Focus on GABAergic neurons2008

    • Author(s)
      Okada T, Tashiro Y, Kato F, Yanagawa Y, Obata K, Kawai Y.
    • Journal Title

      Journal of Chemical Neuroanatomy 35/3

      Pages: 275-284

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative and immunohistochemical analysis of neuronal types in the mouse caudal nucleus tractus solitarius: Focus on GABAergic neurons2008

    • Author(s)
      Okada T, Tashiro Y, Kato F, Yanagawa Y, Obata K, Kawai Y.
    • Journal Title

      Journal of Chemical Neuroanatomy (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glial coverage of the small cell somata in the rat nucleus of tractus solitarius during postnatal development2007

    • Author(s)
      Tashiro Y, Kawai Y
    • Journal Title

      GLIA 55(16)

      Pages: 1619-1629

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and migration of GABAergic neurons in the mouse myelencephalon2007

    • Author(s)
      Tashiro Y, Yanagawa Y, Obata K, Murakami F
    • Journal Title

      J Comp Neurol 503(2)

      Pages: 260-269

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glial coverage of the small cell somata in the rat nucleus of tractus solitarius during postnatal development2007

    • Author(s)
      Tashiro Y, Kawai Y.
    • Journal Title

      GLIA 55

      Pages: 1619-1629

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and migration of GABAergic neurons in the mouse myelen cephalon.2007

    • Author(s)
      Tashiro Y, Yanagawa Y, Obata K, Murakami F.
    • Journal Title

      Journal of Comparative Neurology 503

      Pages: 260-269

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] バルプロ酸胎内曝露ラットにおける脳神経の初期発達2010

    • Author(s)
      太城康良、大薮明子、井村誉史雄、内田敦子、成田正明
    • Organizer
      第115回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] バルプロ酸曝露ラットにおける脳神経の形態発達2009

    • Author(s)
      太城康良、大薮明子、井村誉史雄、内田敦子、成田正明
    • Organizer
      日本解剖学会 第69回 中部支部学術集会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット延髄孤束核における軸索細胞体型シナプスの生後発達2008

    • Author(s)
      太城康良、岡田知明、河合良訓
    • Organizer
      神経科学会第31回神経科学大会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Postnatal development of axosomatic synapses in the rat caudal nucleus of tractus solitarius2008

    • Author(s)
      Tashiro Y, Okada T, Kawai Y
    • Organizer
      Neuroscience Research (Suppl. )
    • Place of Presentation
      第31回神経科学大会(東京)
    • Year and Date
      2008-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット延髄孤束核のシナプス発達と圧受容器反射の獲得2008

    • Author(s)
      岡田知明、太城康良、河合良訓
    • Organizer
      日本解剖学会 第113回総会・全国学術集会
    • Place of Presentation
      大分県 由布市
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット延髄孤束核における軸索細胞体型シナプスの発達2008

    • Author(s)
      太城康良、岡田知明、河合良訓
    • Organizer
      日本解剖学会 第113回総会・全国学術集会
    • Place of Presentation
      大分県 由布市
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of axosomatic synapses in the rat caudal nucleus of tractus solitarius2008

    • Author(s)
      Tashiro Y, Okada T, Kawai Y
    • Organizer
      Acta Anatomica Nipponica
    • Place of Presentation
      第113回日本解剖学会(大分)
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Activity-dependent glial coverage in the rat nucleus of tractus solitarius during postnatal development2007

    • Author(s)
      Tashiro Y, Kawai Y
    • Organizer
      Neuroscience Research
    • Place of Presentation
      第30回神経科学大会(横浜)
    • Year and Date
      2007-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 生後発達期ラット孤束核における神経活動依存的なアストロサイトの被覆2007

    • Author(s)
      太城康良、河合良訓
    • Organizer
      神経科学会 第30回神経科学大会
    • Place of Presentation
      神奈川県 横浜市
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of astrocytic processes in local neural network formation within the caudal nucleus of tractus solitarius during postnatal development2007

    • Author(s)
      Tashiro Y, Kawai Y
    • Organizer
      Acta Anatomica Nipponica
    • Place of Presentation
      第112回日本解剖学会(大阪)
    • Year and Date
      2007-03-28
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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