Augmentation of an immunomodulating activities of functional polysaccharides by an interactive effect with food factors

• Project/Area Number: 19700577
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Miyagi University
• Principal Investigator: MINATO Ken-ichiro Miyagi University, 食産業学部, 講師 (10341728)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,730,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 調理と機能性成分 / 機能性糖鎖 / 免疫調節機能 / 成分間相互作用 / 食用キノコ / ナメコ / タモギタケ / 多糖 / マクロファージ / M1マクロファージ / 免疫調節作用 / 加熱調理 / 食品 / 糖 / ビタミンD2 / 核酸 / サイトカイン / Th1

Research Abstract

It was shown that an immunomodulating activity of functional polysaccharides from edible mushrooms was regulated by some kinds of food factors, such as guanylic acid and vitamin D2, through their interaction. However, it was suggested that their immunomodulating activities were not changed by a differentiation of processing. This work suggested that functional polysaccharides were effective on prevention from disease in our life because of maintenance of their immunomodulating activities.

Research Products

• [Journal Article] ナメコに期待されるガンや生活習慣病予防のための免疫調節作用 (2009)
  • Author(s): 湊健一郎
  • Journal Title: 特産情報 2009年8月号 Pages: 26-28
• [Journal Article] A polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus stimulates an immunomodulating action of murine macrophage, RAW264, on TNF-a and NO productions in vitro (2009)
  • Author(s): Minato K
  • Journal Title: Int. J. Medicin. Mushrooms 10 (3) Pages: 235-244
  • Peer Reviewed
• [Journal Article] A polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus stimulates an immunomodulating action of murine macrophage, RAW264, on TNF-αand NO productions in vitro. (2008)
  • Author(s): Minato K.
  • Journal Title: Int. J. Medicin. Mushrooms 10(3) Pages: 235-244
  • Peer Reviewed
• [Journal Article] immunomodulating action of a polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus. (2008)
  • Author(s): Minato K., Abe C.
  • Journal Title: J. Clin. Biochem. Nutr. 43 Pages: 359-362
  • Peer Reviewed
• [Journal Article] An immunomodulating action of a polysaccharide fraction from an ed ible mushroom, Pleurotus cornucopiae var. citrinopileatus (2008)
  • Author(s): Minato K., and Abe C
  • Journal Title: J. Clin. Biochem. Nutr 43 Pages: 359-362
  • Peer Reviewed
• [Journal Article] AJ polysaccharide fraction from an deible mushroom. Pleurotus conucopiae var.Cirinopileatus stimulates an immunomodulating action of murine macrophage,RAW264,on TNF-a and NO productions in vitro
  • Author(s): Minato K.
  • Journal Title: Int.J.Medicin.Mushrooms (in press)
  • Peer Reviewed
• [Journal Article] An immunomodulating action of a polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var.citrinopileatus
  • Author(s): Minato K. and Abe C.
  • Journal Title: J.Clin, Biochem.Nutr (in press)
  • Peer Reviewed
• [Presentation] タモギタケ、ナメコ中機能性多糖のサイトカイン産生作用の検討 (2010)
  • Author(s): 湊健一郎, 阿部千鶴, 櫻井香子, 田川裕士, 鈴木勇治
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] ナメコ中機能性多糖のサイトカイン産生作用の検討 (2010)
  • Author(s): 湊健一郎, 阿部千鶴, 櫻井香子, 田川裕士, 鈴木勇治, タモギタケ
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
• [Presentation] An immunomodulating action of a polysaccharide from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus (2009)
  • Author(s): Minato K., Abe C., Nakamura K.
  • Organizer: EPNOE 2009
  • Place of Presentation: トゥルク,フィンランド
  • Year and Date: 2009-09-22
• [Presentation] An immunomodulating action of a polysaccharide from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus (2009)
  • Author(s): Minato K., Abe C., Nakamura K.
  • Organizer: EPNOE 2009
  • Place of Presentation: フィンランド
• [Presentation] ナメコの免疫調節作用 (2009)
  • Author(s): 阿部千鶴, 中村香寿実, 湊健一郎
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡
• [Presentation] An immunomodulating action of a polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus. (2009)
  • Author(s): Minato K., Abe C.
  • Organizer: International Conference on Food Factors for Health Promotion 2007
  • Place of Presentation: 京都
• [Presentation] タモギタケ中多糖の免疫調節作用に対するその他食品成分の影響 (2008)
  • Author(s): 湊健一郎, 阿部千鶴
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名古屋
• [Presentation] An immunomodulating action of a polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var.citrinopileatus. (2007)
  • Author(s): Minato K. and Abe C.
  • Organizer: International Conference on Food Factors for Health Promotiom 2007
  • Place of Presentation: 京都
• [Book] Mushrooms: Immunomodulative activity and role in health promotion(in Dietary components and Immune Function.) (2010)
  • Author(s): K. Minato, ed. R.R. Watson, et al.
  • Publisher: Humana Press and Springer
• [Remarks]
  • URL: http://www.myu.ac.jp/kenkyu/h21kakenhi.pdf
• [Remarks]
  • URL: http://www.myu.ac.jp/kenkyu/h2lkakenhi.pdf
• [Remarks]
  • URL: http://www.myu.ac.jp/kenkyu/H19kakenhi.pdf