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Creation of Novel High-Strength Gels by Free Control of Orientation and Their Applications in Biological Fields

Research Project

Project/Area Number 19K21923
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 18:Mechanics of materials, production engineering, design engineering, and related fields
Research InstitutionAkita Prefectural University

Principal Investigator

Jianhui Qiu  秋田県立大学, システム科学技術学部, 教授 (40244511)

Co-Investigator(Kenkyū-buntansha) 伊藤 一志  秋田県立大学, システム科学技術学部, 准教授 (30507116)
境 英一  秋田県立大学, システム科学技術学部, 准教授 (70581289)
Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsハイドロゲル / ソフトマター / 配向性
Outline of Research at the Start

本研究では申請者らが提案した新規な可視光照射により三次元網目構造ゲルを作製し、引張などによりゲルを配向させたまま、セルロース間の水素再結合を引き起こす温度で乾燥させる。その水素結合の不可逆特性を利用して、再度吸水させ、乾燥前の配向ゲルの状態まで回復させる。この新奇な創製方法は配向度を自由に制御できる疑似生体組織の高強度ゲルの作製が可能である。また、作製したゲルに対し、その三次元網目構造におけるセルロース誘導体の役割、力学特性に及ぼす水素再結合や配向度の影響およびゲルの生物適合性と生物学的足場材料への応用を検討する。

Outline of Final Research Achievements

In this study, anisotropic hydrogels were fabricated by drawing, and their performance was evaluated. The results of mechanical properties showed that the difference in tensile strength increased as the shape-fixing temperature increased. The maximum value of tensile strength was obtained at 75°C, and it was found to decrease significantly after 105°C. The results of morphologies showed that the hydrogels were formed at a higher temperature than the shape-fixed hydrogels. The results of the internal structure showed that the pores of the gel contracted as the shape-fixing temperature increased and that the pores were deformed by stretching in the direction perpendicular to the stretching direction. The obtained results indicate that 75°C is the temperature at which the most anisotropic properties can be obtained in this experiment.

Academic Significance and Societal Importance of the Research Achievements

これまでのゲルは、基本的に等方性網目構造が形成され、異方性を持たせることができない。本研究で作製された新奇なゲルは、①ゲルの設計方針や作製プロセスが画期的に転換でき、②ゲルの内部構造を自由に制御できる機能性ゲルの創製が可能になり、生体材料やバイオセンサの学術分野の発展が期待でき、③異方性を活かした新たな学術分野の創出や配向性、力学特性および機能性の組合せにより、様々な特性を賦与させることができ、これまでのソフトマターの学術研究分野に画期的な変革をもたらすことが予想される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 2020 2019 Other

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results) Presentation (4 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Journal Article] A tough hydrogel with fast self-healing and adhesive performance for wearable sensors2022

    • Author(s)
      Lu Chunyin、Qiu Jianhui、Zhao Wei、Sakai Eiichi、Zhang Guohong
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 632 Pages: 127793-127793

    • DOI

      10.1016/j.colsurfa.2021.127793

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low-temperature adaptive conductive hydrogel based on ice structuring proteins/CaCl2 anti-freeze system as wearable strain and temperature sensor2021

    • Author(s)
      Lu Chunyin、Qiu Jianhui、Zhao Wei、Sakai Eiichi、Zhang Guohong、Nobe Rie、Kudo Makoto、Komiyama Takao
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 188 Pages: 534-541

    • DOI

      10.1016/j.ijbiomac.2021.08.060

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simple preparation of carboxymethyl cellulose-based ionic conductive hydrogels for highly sensitive, stable and durable sensors2021

    • Author(s)
      Lu Chunyin、Qiu Jianhui、Sun Manxi、Liu Qifan、Sakai Eiichi、Zhang Guohong
    • Journal Title

      Cellulose

      Volume: 28 Issue: 7 Pages: 4253-4265

    • DOI

      10.1007/s10570-021-03800-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visible light induced synthesis of high toughness, self-healing ionic hydrogel and its application in strain sensing2020

    • Author(s)
      Sun Manxi、Qiu Jianhui、Jin Shuping、Liu Wendi、Sakai Eiichi
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 607 Pages: 125438-125438

    • DOI

      10.1016/j.colsurfa.2020.125438

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity2020

    • Author(s)
      Sun Manxi、Qiu Jianhui、Lu Chunyin、Jin Shuping、Zhang Guohong、Sakai Eiichi
    • Journal Title

      Polymers

      Volume: 12 Issue: 10 Pages: 2263-2263

    • DOI

      10.3390/polym12102263

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Poly(acrylic acid)/palygorskite microgel via radical polymerization in aqueous phase for reinforcing poly(vinyl alcohol) hydrogel2020

    • Author(s)
      Wang Dafeng、Zhu Longxiang、Qiu Jianhui、Zhu Ping
    • Journal Title

      Applied Clay Science

      Volume: 185 Pages: 105421-105421

    • DOI

      10.1016/j.clay.2019.105421

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Strain‐Sensitive Performance of a Tough and Ink‐Writable Polyacrylic Acid Ionic Gel Crosslinked by Carboxymethyl Cellulose2019

    • Author(s)
      Jin Shuping、Qiu Jianhui、Sun Manxi、Huang Hongjian、Sakai Eiichi
    • Journal Title

      Macromolecular Rapid Communications

      Volume: 40 Issue: 20 Pages: 1900329-1900329

    • DOI

      10.1002/marc.201900329

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 優れた力学特性をもつダブルネットワークPAAヒドロゲルの設計と作製2021

    • Author(s)
      陸 春因, 邱 建輝, 劉 啓凡, 境 英一, 張 国宏
    • Organizer
      M&M材料力学カンファレンス 2021年 一般社団法人 日本機械学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Influence of Epoxy Soybean Oil on PVA Hydrogel2019

    • Author(s)
      Manxi Sun, Jianhui Qiu, Shuping Jin, Hongjian Huang, Wendi Liu, Eiichi Sakai
    • Organizer
      The 1st International Symposium on Advanced Materials Science and Engineering (AMSE-1)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Strain-sensitive Performance of a Tough and Ink Writable Polyacrylic Acid Ionic Gel Crosslinked by Carboxymethyl Cellulose2019

    • Author(s)
      Shuping Jin, Jianhui Qiu
    • Organizer
      The 1st International Symposium on Advanced Materials Science and Engineering (AMSE-1)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Characterization of Poly (Vinyl Alcohol)-Epoxidized Soybean Oil Composite Hydrogel2019

    • Author(s)
      Manxi Sun, Jianhui Qiu, Shuping Jin, Hongjian Huang, Wendi Liu , Eiichi Sakai
    • Organizer
      The 1st International Symposium on Advanced Materials Science and Engineering (AMSE-1)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Remarks] 秋田県立大学複合材料研究室HP

    • URL

      https://koubunshiakita.wixsite.com/website

    • Related Report
      2020 Research-status Report
  • [Remarks] 秋田県立大学 システム科学技術学部 機械工学科 複合材料研究室

    • URL

      https://koubunshiakita.wixsite.com/website

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2023-01-30  

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