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Fully implantable and optical wireless neural probe for optogenetics using upconversion nanoparticle

Research Project

Project/Area Number 19K22098
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 28:Nano/micro science and related fields
Research InstitutionTohoku University

Principal Investigator

TANAKA Tetsu  東北大学, 医工学研究科, 教授 (40417382)

Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords神経プローブ / 光遺伝学 / アップコンバージョン / アップコンバージョンナノ粒子 / オプトジェネティクス / 光神経プローブ / 光無線神経プローブ
Outline of Research at the Start

本研究は(1)ナノ粒子によるアップコンバージョンを利用し、近赤外光が届かない標的部位の非侵襲光操作を可能にする体内完全埋植型光無線神経プローブを実現すること、(2)大型動物の光操作や標的部位から離れた部位への近赤外光照射による神経活動操作を可能にすることが目的とし、光遺伝学を脳深部刺激やてんかん治療等の人の医療に適用する端緒を開く。本研究により病気の発生機序が神経学的に明らかにされ、脳深部やてんかん焦点の有線の電気刺激が光による無線の非侵襲刺激に変われば、過電圧・過電流刺激や電池漏電等の人体への危険が無くなり、治療の安全性が飛躍的に向上する。従来の外科的治療の方向性を転換できる可能性がある。

Outline of Final Research Achievements

This study aims to realize a fully implantable optical wireless neural probe by using nanoparticle upconversion. This neural probe enables non-invasive optical manipulation (inhibition and excitation) of target areas where near-infrared light cannot reach by transcutaneous means. This study established a fabrication process of an optical wireless neural probe fully implantable in the body using upconversion nanoparticles. We realized an upconversion neural probe that emits visible light when irradiated with near-infrared light. We have also succeeded in fabricating an upconversion neural probe in which the near-infrared light-irradiating part and the light-emitting part are separated from each other. These results are important for elucidating the development of various diseases and developing safe treatments.

Academic Significance and Societal Importance of the Research Achievements

本研究では、アップコンバージョンナノ粒子を利用した体内完全埋植型の光無線神経プローブの作製プロセスを確立するとともに、近赤外光照射による可視光発光を発光するアップコンバージョン神経プローブを実現した。また、近赤外光照射部と発光部が離れているアップコンバージョン神経プローブの作製にも成功した。これらの成果は、種々の病気の発生機序の解明や安全な治療の開発に繋がる重要な成果と言える。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019 Other

All Presentation (6 results) (of which Int'l Joint Research: 3 results) Book (5 results) Remarks (2 results)

  • [Presentation] Effect of Light Emission on Recording Electrodes of Opto-Neural Probe with Upconversion Nanoparticles2021

    • Author(s)
      楊 芬、浦山 翔太、長崎 春樹、木野 久志、福島 誉史、田中 徹
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多段階励起による発光現象を用いた 光遺伝学用神経メッシュプローブの提案と作製2021

    • Author(s)
      長﨑 春樹、浦山 翔太、楊 芬、木野 久志、福島 誉史、田中 徹
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Fabrication and Evaluation of Neural Recording Microelectrode on Opto-Neural Probe with Upconversion Nanoparticles Light Emitter2020

    • Author(s)
      Fen Yang,Shota Urayama,Haruki Nagasaki, Hisashi Kino, Takafumi Fukushima, Tetsu Tanaka
    • Organizer
      2020 International Conference on Solid State Devices and Materials
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Optical Waveguiding Neural Probe with Upconversion-Nanoparticle Light Emitter for Optogenetics2020

    • Author(s)
      Shota Urayama, Fen Yang, Haruki Nagasaki, Hisashi Kino, Takafumi Fukushima, Tetsu Tanaka
    • Organizer
      2020 International Conference on Solid State Devices and Materials
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Wireless Opto-Neural Probe with Upconversion Nanoparticles (UCNP) for Optogenetics2019

    • Author(s)
      Shota Urayama, Hisashi Kino, Takafumi Fukushima, and Tetsu Tanaka
    • Organizer
      2019 International Conference on Solid State Devices and Materials
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光遺伝学用UCNPオプト神経プローブの発光強度特性評価2019

    • Author(s)
      浦山 翔太、木野 久志、福島 誉史、田中 徹
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Research-status Report
  • [Book] マウス・ラット モデル作製・解析プロフェッショナル 第3章 生理機能の解析 4.多機能整理計測プラットフォーム2021

    • Author(s)
      虫明 元、田中 徹、片山 統裕、小山内 実
    • Publisher
      羊土社
    • ISBN
      9784758121125
    • Related Report
      2020 Annual Research Report
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Advances in Experimental Medicine and Biology, 1293) 31 Multimodal Functional Analysis Platform: 1. Ultrathin Fluorescence Endoscope Imaging System Enables Flexible Functional Brain Imaging2021

    • Author(s)
      Makoto Osanai, Hideki Miwa, Atsushi Tamura, Satomi Kikuta, Yoshio Iguchi, Yuchio Yanagawa, Kazuto Kobayashi, Norihiro Katayama, Tetsu Tanaka, Hajime Mushiake
    • Publisher
      Springer
    • ISBN
      9789811587627
    • Related Report
      2020 Annual Research Report
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Advances in Experimental Medicine and Biology, 1293) 32 Multimodal Functional Analysis Platform: 2. Development of Si Opto-Electro Multifunctional Neural Probe with Multiple Optical Waveguides and Embedded Optical Fiber for Optogenetics2021

    • Author(s)
      Tetsu Tanaka, Norihiro Katayama, Kazuhiro Sakamoto, Makoto Osanai, Hajime Mushiake
    • Publisher
      Springer
    • ISBN
      9789811587627
    • Related Report
      2020 Annual Research Report
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Advances in Experimental Medicine and Biology, 1293) 33 Multimodal Functional Analysis Platform: 3. Spherical Treadmill System for Small Animals2021

    • Author(s)
      Norihiro Katayama, Mitsuyuki Nakao, Tetsu Tanaka, Makoto Osanai, Hajime Mushiake
    • Publisher
      Springer
    • ISBN
      9789811587627
    • Related Report
      2020 Annual Research Report
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Advances in Experimental Medicine and Biology, 1293) 34 Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits2021

    • Author(s)
      Hajime Mushiake, Tomokazu Ohshiro, Shin-ichiro Osawa, Ryosuke Hosaka, Norihiro Katayama, Tetsu Tanaka, Hiromu Yawo, Makoto Osanai
    • Publisher
      Springer
    • ISBN
      9789811587627
    • Related Report
      2020 Annual Research Report
  • [Remarks] 田中(徹)・木野/福島研究室Homepage

    • URL

      http://www.lbc.mech.tohoku.ac.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 田中(徹)・木野/福島研究室

    • URL

      http://www.lbc.mech.tohoku.ac.jp/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2023-01-30  

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