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Development of a true social evaluation system and central drug efficacy evaluation

Research Project

Project/Area Number 19K22373
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Research InstitutionAzabu University

Principal Investigator

Kikusui Takefumi  麻布大学, 獣医学部, 教授 (90302596)

Co-Investigator(Kenkyū-buntansha) 野元 謙作  麻布大学, 獣医学部, 特任助教 (30786976)
茂木 一孝  麻布大学, 獣医学部, 教授 (50347308)
Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsマウス / 集団 / 認知機能 / 自閉症モデルマウス / 社会性 / 自動解析 / 集団行動 / LMT / トラッキング / 行動薬理
Outline of Research at the Start

最大8個体のマウスを同一空間内で、4週間にも及ぶ群れ飼育を行い、その位置情報のみならず、AIを用いて親和行動や敵対行動などの40もの行動カテゴリーのリアルタイム分類に成功した。そこで本研究では、本システムを用いて複雑な社会におけるマウスの行動薬理実験に関して、以下を実施する。1)マウスの複雑な社会環境における新たな網羅的行動テスト手法の確立、2)確立した手法を用いた自閉症モデルマウスや社会性障害モデルを用いた行動評価と薬効評価、3)複雑な社会性に関わる分子・神経回路の同定を目指す。

Outline of Final Research Achievements

In a social group, each individual has a process to develop inter-individual relationships based on interactions and to acquire a role in the group. The purpose of this study was to clarify the emergence of social diversity and the formation of the phenotype of the autism model mouse by experiencing a group housing. Four individuals of mice were reared in a group for 4 weeks in the same space. We conducted an analysis of their location information and behaviors such as affiliation and agonistic behaviors, as well as a battery of behavioral tests such as object recognition, place recognition, and social recognition after the experience of group behavior. As a result, it was found that the accumulation of daily exercise by spatial enrichment changed the behavioral phenotype in the adult stage and improved spatial cognitive ability and social cognitive ability. On the other hand, no change in social cognitive ability was observed in the autism model mice.

Academic Significance and Societal Importance of the Research Achievements

うつ病は成人の15名に1人が罹患している現代社会の抱える重大な問題である。現在、うつ病、引きこもり、自殺による経済的損失は年間3兆円を超え(厚生労働省)、この10年以上、悪化の一途をたどっている。特にその要因の多くは対人関係における不適合にある。また自閉症スペクトラム障害を代表とする発達障害の罹患率も増加の一途をたどり、国家をあげた対応が望まれている。今回、マウスモデルを用いて、複雑な社会性における認知機能の変化を見出した。これらのモデルを用いて、神経科学的因果関係の追求、さらには薬物による治療効果などの評価が可能となり、将来的には前臨床試験の一部として利用可能であることが示された。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (27 results)

All 2021 2020 2019 Other

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 9 results) Presentation (12 results) (of which Invited: 12 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Low maternal licking/grooming stimulation increases pain sensitivity in male mouse offspring.2021

    • Author(s)
      T. Sakamoto, Y Ishio, Y Ishida, K. Mogi, T. Kikusui
    • Journal Title

      Experimental Animals

      Volume: 70(1) Issue: 1 Pages: 13-21

    • DOI

      10.1538/expanim.20-0030

    • NAID

      130007981761

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypothalamic perifornical Urocortin-3 neurons modulate defensive responses to a potential threat stimulus2021

    • Author(s)
      Horii-Hayashi Noriko、Nomoto Kensaku、Endo Nozomi、Yamanaka Akihiro、Kikusui Takefumi、Nishi Mayumi
    • Journal Title

      iScience

      Volume: 24 Issue: 1 Pages: 101908-101908

    • DOI

      10.1016/j.isci.2020.101908

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli2021

    • Author(s)
      Inoue N, Nishizumi H, Ooyama R, Mogi K, Nishimori K, Kikusui T, Sakano H
    • Journal Title

      eLife

      Volume: 10 Pages: 65078-65078

    • DOI

      10.7554/elife.65078

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The blockade of oxytocin receptors in the paraventricular thalamus reduces maternal crouching behavior over pups in lactating mice.2020

    • Author(s)
      A. Watarai, S. Tsutaki, K. Nishimori, T. Okuyama, K. Mogi, T. Kikusui
    • Journal Title

      Neuroscience Letters

      Volume: 720 Pages: 134761-134761

    • DOI

      10.1016/j.neulet.2020.134761

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbial colonization history modulates anxiety-like and complex social behavior in mice2020

    • Author(s)
      Kamimura Itsuka、Kaneko Ryou、Morita Hidetoshi、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 64-75

    • DOI

      10.1016/j.neures.2020.01.001

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Female C57BL/6 and BALB/c mice differently use the acoustic features of male ultrasonic vocalizations for social preferences2020

    • Author(s)
      NOMOTO Kensaku、HASHIGUCHI Akiko、ASABA Akari、OSAKADA Takuya、KATO Masahiro、KOSHIDA Nobuyoshi、MOGI Kazutaka、KIKUSUI Takefumi
    • Journal Title

      Experimental Animals

      Volume: in press Issue: 3 Pages: 1341-1357

    • DOI

      10.1538/expanim.19-0119

    • NAID

      130007884753

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism.2020

    • Author(s)
      Risa Kato, Akihiro Machida, Kensaku Nomoto, Gina Kang, Takeshi Hiramoto, Kenji Tanigaki, Kazutaka Mogi, Noboru Hiroi, Takefumi Kikusui
    • Journal Title

      Dev Psychobiol

      Volume: 63 Issue: 1 Pages: 108-113

    • DOI

      10.1002/dev.22006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an <i>in vivo</i> microdialysis study of male rats2020

    • Author(s)
      TAKITA Masatoshi、KIKUSUI Takefumi
    • Journal Title

      Experimental Animals

      Volume: 69 Issue: 4 Pages: 382-387

    • DOI

      10.1538/expanim.20-0015

    • NAID

      130007938668

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Testosterone regulates the emission of ultrasonic vocalizations and mounting behavior during different developmental periods in mice2020

    • Author(s)
      Kikusui Takefumi、Shima Yuichi、Sonobe Miku、Yoshida Yuuki、Nagasawa Miho、Nomoto Kensaku、Mogi Kazutaka
    • Journal Title

      Developmental Psychobiology

      Volume: 0 Issue: 4 Pages: 0-0

    • DOI

      10.1002/dev.22045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endocrine Regulations in Human?Dog Coexistence through Domestication2019

    • Author(s)
      Kikusui Takefumi、Nagasawa Miho、Nomoto Kensaku、Kuse-Arata Sayaka、Mogi Kazutaka
    • Journal Title

      Trends in Endocrinology & Metabolism

      Volume: 30 Issue: 11 Pages: 793-806

    • DOI

      10.1016/j.tem.2019.09.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low maternal care enhances the skin barrier resistance of offspring in mice2019

    • Author(s)
      Sakamoto Takashi、Ishio Yukino、Ishida Yuiko、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 7 Pages: e0219674-e0219674

    • DOI

      10.1371/journal.pone.0219674

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex2019

    • Author(s)
      Kikusui Takefumi、Kanbara Natsumi、Ozaki Mariya、Hirayama Nozomi、Ida Kumiko、Tokita Mika、Tanabe Naho、Mitsuyama Kuriko、Abe Hatsuki、Yoshida Miki、Nagasawa Miho、Mogi Kazutaka
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3991-3991

    • DOI

      10.1038/s41598-019-40530-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference2019

    • Author(s)
      Kamimura Itsuka、Watarai Akiyuki、Takamura Takuma、Takeo Atsushi、Miura Kyoko、Morita Hidetoshi、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Developmental Psychobiology

      Volume: in press Issue: 5 Pages: 670-678

    • DOI

      10.1002/dev.21827

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 社会内分泌学:社会をつくる内分泌の役割2020

    • Author(s)
      菊水健史
    • Organizer
      日本神経科学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Oxytocin modulates emotional tear2019

    • Author(s)
      Takefumi Kikusui, Kaori Murata, Toshihiro Imada, Kai Jin, Kazutaka Mogi, Miho Nagasawa, Shigeru Nakamura, Kazuo Tsubota
    • Organizer
      Neuro2019 日本神経科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] オキシトシンによる情動性の涙の制御2019

    • Author(s)
      菊水健史
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] イヌとヒトの共生の歴史2019

    • Author(s)
      菊水健史
    • Organizer
      FASAVATOKYO 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 動物の感覚2019

    • Author(s)
      菊水健史
    • Organizer
      自治医科大学「実験動物慰霊の会」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ヒトとイヌの関係とその効果2019

    • Author(s)
      菊水健史
    • Organizer
      第8回「ペットとの共生推進協議会シンポジウム」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ヒトとイヌ・共生と互恵的関係」-家族をつなぐホルモンの効果-2019

    • Author(s)
      菊水健史
    • Organizer
      2019年群馬県高崎市市民講座
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 動物の多様な感覚と行動2019

    • Author(s)
      菊水健史
    • Organizer
      2019年筑波実験動物研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 社会内分泌学2019

    • Author(s)
      菊水健史
    • Organizer
      第1271回東京大学生物科学セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 動物学からみた「目」のもつ社会機能2019

    • Author(s)
      菊水健史
    • Organizer
      View2019学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 母子間関係性の内分泌制御2019

    • Author(s)
      菊水健史
    • Organizer
      2019「薬物・精神・行動の会」特別講演
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 哺乳類の性2019

    • Author(s)
      菊水健史
    • Organizer
      新学術領域研究「性スペクトラム」アウトリーチ講座
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] 社会の起源2019

    • Author(s)
      菊水 健史、市川 眞澄
    • Total Pages
      162
    • Publisher
      共立出版
    • ISBN
      4320057961
    • Related Report
      2019 Research-status Report
  • [Remarks] 麻布大学介在動物学研究室

    • URL

      https://sites.google.com/carazabu.com/lab-kaizai/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2019-07-04   Modified: 2022-01-27  

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