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Control of muscle fiber properties by diversity of fatty acid species that bind to phospholipids

Research Project

Project/Area Number 19K22814
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionUniversity of Shizuoka

Principal Investigator

Miura Shinji  静岡県立大学, 食品栄養科学部, 教授 (10342932)

Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsリポクオリティ / ホスファチジルコリン / アシル基転移酵素 / 骨格筋 / リモデリング / リン脂質
Outline of Research at the Start

生体内には数多くの脂質分子種が存在し、その多様性が生体機能制御に関与することが類推されているが、その分子実体やメカニズムについては不明な点が多い。生体膜の構成成分であるホスファチジルコリン(PC)は、結合している脂肪酸の組み合わせから数多くの分子種が存在する。申請者らはこれまでに、骨格筋に含まれるPC分子種が筋線維タイプによって異なることを明らかにし、それが筋線維の特性に寄与している可能性を示唆している。本研究課題は、骨格筋の筋線維タイプによるPC分子種の相違を手がかりに、未だ解明されていない「“生体を構成する脂質の質”と生体機能の関係」を明らかにしようとする挑戦的な研究課題である。

Outline of Final Research Achievements

Skeletal muscles are roughly divided into fast-twitch muscles with a high contraction rate and slow-twitch muscles with a slow contraction rate. Previous studies have suggested that the fatty acid species that bind to phosphatidylcholine (PC) in muscle differ depending on the muscle fiber type, but the mechanism by which the difference in PC molecular species occurs and its physiological significance have not been elucidated. In this study, we revealed that the fast-twitch muscle contained 16:0-PC, and the slow-twitch muscle contained 18:0-PC in addition to 16:0-PC. Furthermore, we showed that acyltransferase LPLAT1 increased the amount of 18:0-PC in muscle and these changes in the fatty acid species that bind to PC had a great effect on muscle properties and functions.

Academic Significance and Societal Importance of the Research Achievements

従来の栄養学では、“摂取する脂質の量や質”と生体機能や疾病発症との関係性が重要視され、“生体を構成する脂質の質”と生体機能の関係性まで踏み込んだ解析はされてこなかったが、組織におけるPC分子種の質がその機能に重要な働きをしていることが判明し、栄養学における脂質の新たな意義を見出した。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (9 results) (of which Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Differences in phosphatidylcholine profiles and identification of characteristic phosphatidylcholine molecules in meat animal species and meat cut locations2021

    • Author(s)
      Yamamoto Shunsuke、Kato Shigeki、Senoo Nanami、Miyoshi Noriyuki、Morita Akihito、Miura Shinji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 5 Pages: 1205-1214

    • DOI

      10.1093/bbb/zbab010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic analysis on blood of transgenic mice overexpressing PGC-1α in skeletal muscle2021

    • Author(s)
      Sugimoto Takumi、Uchitomi Ran、Hatazawa Yukino、Miura Shinji、Kamei Yasutomi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 3 Pages: 579-586

    • DOI

      10.1093/bbb/zbaa059

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The presence of odd-chain fatty acids in Drosophila phospholipids2020

    • Author(s)
      Sato Ayaka、Ohhara Yuya、Miura Shinji、Yamakawa-Kobayashi Kimiko
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 10 Pages: 2139-2148

    • DOI

      10.1080/09168451.2020.1790337

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycerophospholipid profile alterations are associated with murine muscle‐wasting phenotype2020

    • Author(s)
      Senoo Nanami、Miyoshi Noriyuki、Kobayashi Eri、Morita Akihito、Tanihata Jun、Takeda Shin'ichi、Miura Shinji
    • Journal Title

      Muscle & Nerve

      Volume: 62 Issue: 3 Pages: 413-418

    • DOI

      10.1002/mus.26993

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolomic analysis of skeletal muscle in aged mice.2019

    • Author(s)
      Uchitomi, R., Hatazawa, Y., Senoo, N., Yoshioka, K., Fujita, M., Shimizu, T., Miura, S., Ono, Y., and Kamei, Y.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 10425-10425

    • DOI

      10.1038/s41598-019-46929-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of myofiber type-specific molecules using mass spectrometry imaging.2019

    • Author(s)
      Goto-Inoue, N., Morisasa, M., Machida, K., Furuichi, Y., Fujii, N.L., Miura, S., and Mori, T.
    • Journal Title

      Rapid Commun Mass Spectrom

      Volume: 33 Issue: 2 Pages: 185-192

    • DOI

      10.1002/rcm.8319

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨格筋を構成するリン脂質の「質」と機能性に関する研究2021

    • Author(s)
      三浦進司
    • Organizer
      日本生物工学会2020年度 第2回脂質駆動学術産業創生研究部会講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 骨格筋リポクオリティの制御機構と運動およびPGC-1αの影響2020

    • Author(s)
      三浦進司
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 持久運動トレーニングによる骨格筋リポクオリティの変化2020

    • Author(s)
      三浦菜穂、市田日和、梅林脩平、妹尾奈波、三好規之、守田昭仁、三浦進司
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 加齢性サルコペニアの骨格筋における代謝産物変化の網羅的解析2020

    • Author(s)
      内富蘭、畑澤幸乃、妹尾奈波、吉岡潔志、藤田真理子、清水孝彦、三浦進司、小野悠介、亀井康富
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] LPGAT1が筋線維タイプにおけるリン脂質クオリティと機能の相違を生み出す2020

    • Author(s)
      市田日和、梅林脩平、赤堀拓、妹尾奈波、佐藤友紀、三好規之、吉田卓矢、守田昭仁、杉浦悠毅、井上菜穂子、川名裕己、青木淳賢、藤井宣晴、眞鍋康子、亀井康富、三浦進司
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 骨格筋を構成するリン脂質の「質」制御機構に関する研2019

    • Author(s)
      三浦進司
    • Organizer
      第10回機能油脂懇話会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] リピドミクス解析を活用した食肉評価および栄養素摂取比率の推定2019

    • Author(s)
      三浦進司、妹尾奈波、梅林脩平、井上瑞樹、山本俊佑、三好規之、守田昭仁、亀井康富
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 骨格筋の膜リン脂質多様性を生み出す機構2019

    • Author(s)
      妹尾奈波
    • Organizer
      第20回静岡ライフサイエンスシンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Control mechanisms of myofiber type-specific fatty acid profiles in glycerophospholipids2019

    • Author(s)
      Akahori, T., Umebayashi, S., Senoo, N., Sato, T., Miyoshi, N., Yoshida, T., Morita, A., Sugiura, Y., Goto-Inoue, N., Kamei, Y., and Miura, S.
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Research-status Report
  • [Book] 生体におけるリン脂質の性状と機能性2020

    • Author(s)
      機能油脂懇話会
    • Total Pages
      152
    • Publisher
      建帛社
    • ISBN
      9784767962153
    • Related Report
      2020 Annual Research Report
  • [Remarks] 運動はなぜ健康にいい? 栄養学が解明する筋肉・脂質の謎

    • URL

      https://yumenavi.info/lecture.aspx?GNKCD=g010319

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2022-01-27  

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