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Non-elastic light scattering interferometer for chemical contrast tomography

Research Project

Project/Area Number 19K22979
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionTokyo University of Science

Principal Investigator

Yui Hiroharu  東京理科大学, 理学部第一部化学科, 教授 (20313017)

Co-Investigator(Kenkyū-buntansha) 浦島 周平  東京理科大学, 理学部第一部化学科, 助教 (30733224)
森作 俊紀  東京理科大学, 研究推進機構総合研究院, 助教 (00468521)
Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords局所粘弾性 / 光音響 / 光干渉計 / イメージング / トモグラフィー / 光散乱 / パワースペクトル / 光干渉 / 顕微鏡 / レオロジー / 分子種識別断層画像 / 誘導ラマン散乱 / OCT / 近赤外光 / ヘテロダイン干渉 / 後方散乱光エンハンスメント現象
Outline of Research at the Start

非弾性散乱光である誘導ラマン散乱(SRS)光に基づく新規な化学コントラスト光干渉断層計を開発する。当該装置を眼底検査用や皮膚を模倣した光学ファントムに適用し、目的分子種選択的な断層画像を構築する。

Outline of Final Research Achievements

At first, we have developed a stimulated Raman scattering interferometer, which enables us to identify chemical species of buried structures in materials with a high spatial resolution. This technique was applied to nanometer-structured silicon wafers buried in water, and it was demonstrated that the water went into the nanometer-sized holes on the wafers were observable even under buried configuration.
Then, dynamic light scattering and photoacoustic waveform imaging techniques were developed for viscoelastic imaging of local areas in the samples. The former successfully tracked spatially and temporarily heterogeneous viscoelasticity of condensed slurries flowing/drying on rough surfaces. The latter probed the elasticity of samples buried in strong light scatterer. varying wide-range of tens to thousands kPa in Young’s modulus.

Academic Significance and Societal Importance of the Research Achievements

時空間的に不均一な試料の分子分布や局所粘弾性を高空間分解能で計測できることは、医療診断や食品の検査に重要である。濃厚コロイド分散系や光散乱体に埋もれた構造体は食品・医薬品・生体組織内部などに普遍的に存在するため、本課題で開発した手法の応用範囲は多岐にわたる。
実際に本手法は多くの注目を集め、例えば生きたままの動物の内部組織における局所粘弾性を直接計測・イメージングする発展的研究として、AMED-CRESTの研究課題(加齢性難聴の克服に資する次世代型医療の基盤技術の創出、研究代表者:日比野浩(大阪大学)、分担研究)へと昇華した。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Development of dark-field dynamic light scattering microscopy and its application: Tracking dynamics of particles in condensed slurries spreading on planar/nonplanar substrates2021

    • Author(s)
      Masaru Shiraishi, Shu-hei Urashima, Toshinori Morisaku, Rui Takahashi, Keiko Matsuo, Hiroharu Yui
    • Journal Title

      JOURNAL OF COLLOID AND INTERFACE SCIENCE

      Volume: 584 Pages: 723-728

    • DOI

      10.1016/j.jcis.2020.09.095

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Elasticity of Small Objects Buried in Media Based on the Measurements of Photoacoustic Temporal Waveforms2020

    • Author(s)
      Ayaka Naka, Toshinori Morisaku, Shu-hei Urashima, Hiroharu Yui
    • Journal Title

      Analytical Sciences

      Volume: 36 Issue: 12 Pages: 1487-1493

    • DOI

      10.2116/analsci.20P076

    • NAID

      130007952882

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2020-12-10
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of Water Distribution on Micro-structured Surface Buried in Water as a Model of Super Water Repellent Surface by Stimulated Raman Scattering Interferometer2019

    • Author(s)
      Motohiro Banno, Sumire Takahashi, Hiroharu Yui
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 8 Pages: 911-915

    • DOI

      10.2116/analsci.19P060

    • NAID

      130007689351

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-08-10
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 光音響法を用いた生体模倣試料の局所弾性計測2021

    • Author(s)
      浦島周平、木村 真衣子、森作 俊紀、由井 宏治
    • Organizer
      2021(令和3)年度 生理研研究会 細胞の局所コミュニティ研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Contribution of the thermal fluctuation of lipid bilayers to the control of membrane fusion: Development of an evanescent-wave illumination dynamic light scattering microscope2019

    • Author(s)
      Miki Sunada, Toshinori Morisaku, Atsushi Miyazaki, Takaya Sakai, Keiko Matsuo, Hiroharu Yui
    • Organizer
      Okinawa Colloids 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dark-field laser speckle microscope for micro-rheological measurements of slurries on a substrate during wetting and spreading accompanied by drying2019

    • Author(s)
      Masaru Shiraishi, Toshinori Morisaku, Rui Takahashi, Yuu Oshima, Shu-hei Urashima, Keiko Matsuo, Hiroharu Yui
    • Organizer
      Okinawa Colloids 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-07-04   Modified: 2023-01-30  

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