Colloidal Platinum Nanoparticles and Phospphorylated Pullulan improve the pulp capping capability of Mineral trioxide Aggregate
| Project/Area Number |
19K24110
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2021-03-31
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| Project Status |
Granted (Fiscal Year 2019)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Pulp capping / MTA / Inflammation / Mineralization / CPN / Pulpal response / Pullulan (PL) / Biocompatibility |
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| Outline of Research at the Start |
To evaluate:
rats’ pulpal response to capping with a new MTA containing PL and CPN,
adhesive ability of both PL and CPN by microtensile bond strength test employing extracted human molars,
sealing capability of PL and CPN by SEM and TEM,
biocompatibility of CPN by using human immortalized pulp cells.
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| Outline of Annual Research Achievements |
Therapeutic role of Colloidal Platinum Nanoparticles (CPN)in capping the Wister rat's exposed pulp was evaluated after 3, 7, and 28 days. The effects were compared with the effects of Mineral trioxide aggregate (MTA) in similar experimental conditions. CPN showed favorable healing response in Wister rat's dental pulp. The responses were comparable to the responses of the "gold standard" pulp capping material MTA. Our observations were accepted for oral presentation in the 98th General Session of the IADR scheduled from March 18-21, 2020 at Washington DC, USA. Abstract's control ID: 3318137. Title: Effects of Colloidal platinum Nanoparticles on Dental Pulp. The characteristic of the mineralized tissue was evaluated at University of Granada, Spain, where I was also invited to deliver a lecture on our research achievement.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The study was designed carefully. The working plan was explicit. I stuck to the plans and worked hard to complete everything in time.
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| Strategy for Future Research Activity |
Experiments are being done to determine the mechanism of action, optimum dosage, and suitable carrier of Colloidal Platinum Nanoparticles.
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Report
(1 results)
Research Products
(2 results)
