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Basic research for devising measures for the global control of newly discovered pathogenic Babesia in cattle

Research Project

Project/Area Number 19KK0174
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

Yokoyama Naoaki  帯広畜産大学, 原虫病研究センター, 教授 (80301802)

Co-Investigator(Kenkyū-buntansha) 白藤 梨可  帯広畜産大学, 原虫病研究センター, 准教授 (00549909)
ティルラセンバラム シヴァクマール  帯広畜産大学, 原虫病研究センター, 特任研究員 (00826711)
Project Period (FY) 2019-10-07 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2021: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
KeywordsBabesia naoakii / 牛バベシア病 / Babesia sp. Mymensingh / 国際防疫体制強化 / PCR / Babesia bovis / Babesia bigemina / 牛 / ラクダ / モンゴル / バベシア / スリランカ / バベシア病 / 国際分布調査 / 感染宿主 / リスク評価 / 疾病制御 / 家畜法定伝染病 / マダニ
Outline of Research at the Start

新バベシア(Babesia sp. Mymensingh)は2種類の高病原性牛バベシア(Babesia bovisとBabesia bigemina)に続く第3の病原性牛バベシアである。この新バベシアの実態を把握するための学術基盤の構築は喫緊の課題である。そこで新バベシアは、1)どの程度の病原性を示すのか? 2)どこまで世界に浸透しているのか? 3)どこから分岐して誕生したバベシアなのか? 4)どのようなマダニ種によって媒介されるのか? 5)どの程度の宿主域を持ち、どの宿主が感染源となるのか? などの学術的な「問い」を解決し、国際防疫体制強化に資する研究基盤を整えていく。

Outline of Final Research Achievements

Blood DNA samples of cattle, buffalo, goats, sheep, and camels from Sri Lanka, Mongolia, the Philippines, Vietnam, Egypt, Uganda, Brazil, and Argentina were screened using a parasite-specific diagnostic PCR assay. The results showed that the novel bovine Babesia species (Babesia sp. Mymensingh) infects not only cattle but also buffalo, sheep, goats, and camels in Asian, African, and South American countries. Our subsequent in-debt morphological and genetic analyses found that the Babesia species was a distinct parasite species and therefore, provided with an official scientific name "Babesia naoakii". Babesia naoakii, which causes a severe form of bovine babesiosis, has been registered in the ZooBank and described as a novel species in a scientific publication.

Academic Significance and Societal Importance of the Research Achievements

Babesia naoakiiは、我が国で家畜法定伝染病の病原体に指定されている既知のBabesia bovisとBabesia bigeminaに続く、第3の病原性牛バベシアとなった。このようなリスクの高い海外悪性病原体は、常に水際で我が国への侵入を厳重に食い止める必要があるが、研究開始時では動物検疫所でその感染検体を確保することができない状況にあった。そのため、遺伝子診断法の確立と学名の登録まで完了した本研究の成果は、我が国の防疫体制の向上に向けて極めて大きい意義を持つ。また、今後もOIEリファレンスラボラトリーの専門家として牛バベシア病に関する研究をリードできる学術基盤も構築できた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (32 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (17 results) Journal Article (8 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] Veterinary Research Institute/Dep. of Animal Production & Health(スリランカ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Sohag University/Assiut University(エジプト)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Institute of Veterinary Medicine/Mongolian University of Life Sciences(モンゴル)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Institute of Veterinary Medicine(モンゴル)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Veterinary Research Institute(スリランカ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Institute of Veterinary Medicine(モンゴル)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Veterinary Research Institute(スリランカ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Hue University(ベトナム)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Cebu Technological University(フィリピン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Makerere University(ウガンダ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] 獣医学研究所(スリランカ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] フィリピン・セブ工科大学(その他の国・地域)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] フエ大学(ベトナム)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] 獣医学研究所(モンゴル)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] マケレレ大学(ウガンダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2019 Research-status Report
  • [Journal Article] Phylogenetic analyses of the mitochondrial, plastid, and nuclear genes of Babesia sp. Mymensingh and its naming as Babesia naoakii n. sp.2022

    • Author(s)
      Sivakumar T, Tuvshintulga B, Otgonsuren D, Batmagnai E, Ahedor B, Kothalawala H, Vimalakumar SC, Silva SSP, Yamagishi J, Yokoyama N.
    • Journal Title

      Parasites & Vectors

      Volume: 15 Issue: 1 Pages: 299-299

    • DOI

      10.1186/s13071-022-05374-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular survey of Babesia, Theileria, Trypanosoma, and Anaplasma infections in camels (Camelus dromedaries) in Egypt2022

    • Author(s)
      Salman D, Sivakumar T, Otgonsuren D, Mahmoud ME, Elmahallawy EK, Khalphallah A, Kounour AMEY, Bayomi SA, Igarashi M, Yokoyama N.
    • Journal Title

      Parasitology International

      Volume: 90 Pages: 102618-102618

    • DOI

      10.1016/j.parint.2022.102618

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular survey of bovine Babesia species in Bactrian camels (Camelus bactrianus) in Mongolia2022

    • Author(s)
      Otgonsuren Davaajav、Sivakumar Thillaiampalam、Yokoyama Naoaki et al
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 13 Issue: 1 Pages: 101871-101871

    • DOI

      10.1016/j.ttbdis.2021.101871

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Geographic origin of Explanatum explanatum (Creplin, 1847) Fukui, 1929 detected from domestic water buffaloes in Sri Lanka2021

    • Author(s)
      Thang Tran Nhat、Sivakumar Thillaiampalam、Kothalawala Hemal、Silva Seekkuge Susil Priyantha、Yokoyama Naoaki、Ichikawa-Seki Madoka
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 91 Pages: 104806-104806

    • DOI

      10.1016/j.meegid.2021.104806

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Host range and geographical distribution of Babesia sp. Mymensingh2020

    • Author(s)
      Sivakumar Thillaiampalam、Tuvshintulga Bumduuren、Kothalawala Hemal、Silva Seekkuge Susil Priyantha、Lan Dinh Thi Bich、Long Phung Thang、Yba?ez Adrian Patalinghug、Yba?ez Rochelle Haidee Daclan、Francisco Benitez Daniel、Tayebwa Dickson Stuart、DE Macedo Alan Caine Costa、Schnittger Leonhard、Yokoyama Naoaki
    • Journal Title

      Transboundary and Emerging Diseases

      Volume: - Pages: 2233-2239

    • DOI

      10.1111/tbed.13546

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular epidemiological survey of Babesia bovis, Babesia bigemina, and Babesia sp. Mymensingh infections in Mongolian cattle2020

    • Author(s)
      Otgonsuren Davaajav、Sivakumar Thillaiampalam、Tuvshintulga Bumduuren、Yokoyama Naoaki et al.
    • Journal Title

      Parasitology International

      Volume: 77 Pages: 102107-102107

    • DOI

      10.1016/j.parint.2020.102107

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessing the Immunochromatographic Test Strip for Serological Detection of Bovine Babesiosis in Uganda2020

    • Author(s)
      Stuart Tayebwa Dickson、Magdy Beshbishy Amany、Batiha Gaber El-Saber、Komugisha Mariam、Joseph Byaruhanga、Vudriko Patrick、Yahia Ramadan、Alkazmi Luay、Hetta Helal F.、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 8 Pages: 1110-1110

    • DOI

      10.3390/microorganisms8081110

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of a new Theileria sp. closely related to Theileria annulata in cattle from Sri Lanka2019

    • Author(s)
      Sivakumar Thillaiampalam、Fujita Shiori、Tuvshintulga Bumduuren、Kothalawala Hemal、Silva Seekkuge Susil Priyantha、Yokoyama Naoaki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-52512-y

    • NAID

      120006769784

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] An introduction to our collaboration with OIE2021

    • Author(s)
      Naoaki Yokoyama
    • Organizer
      The 1st International Conference of Advanced Veterinary Science and Technologies for Sustainable Development
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A success story of SATREPS project: Control of protozoan diseases to improve livestock production in Mongolia2020

    • Author(s)
      Naoaki Yokoyama
    • Organizer
      第89回日本寄生虫学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Host range and distribution of Babesia sp. Mymensingh2019

    • Author(s)
      横山直明、Sivakumar, T.
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Molecular epidemiology of virulent Babesia parasites in Mongolian cattle2019

    • Author(s)
      Otogonsuren, D., Sivakumar, T., Battur, B., Battsetseg, B., 横山直明
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Discovery of a new Theileria species closely related to Theileria annulata in cattle from Sri Lanka2019

    • Author(s)
      Sivakumar, T., 横山直明
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Remarks] OIE Reference Centres

    • URL

      https://www.obihiro.ac.jp/facility/protozoa/en/oie-reference-centres

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
  • [Remarks] 帯広畜産大学・原虫病研究センター

    • URL

      https://www.obihiro.ac.jp/facility/protozoa/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report

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Published: 2019-10-10   Modified: 2024-01-30  

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