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A cross cohort study on women health: comparisons between Japanese and women in other countries

Research Project

Project/Area Number 19KK0235
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionGunma University

Principal Investigator

Hayashi Kunihiko  群馬大学, その他部局等, 理事 (80282408)

Co-Investigator(Kenkyū-buntansha) 李 廷秀  東京医療保健大学, 医療保健学研究科, 教授 (60292728)
井手野 由季  群馬大学, 数理データ科学教育研究センター, 准教授 (60616324)
長井 万恵  群馬大学, 数理データ科学教育研究センター, 准教授 (90760067)
Project Period (FY) 2019-10-07 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords女性コホート研究 / 女性の健康 / ライフコース・アプローチ / 日本ナースヘルス研究 / 国際クロスコホート・コンソーシアム / 国際クロスコホート研究 / 国際クロス・コホート研究
Outline of Research at the Start

日本ナースヘルス研究(JNHS)は,これまでコホート登録時の断面調査データをInterLACEに提供してきたが,本国際共同研究では,登録後10年間のJNHS追跡データを追加提供することで,新たな世界規模の統合データを共同で作成する。そして,JNHS研究者がInterLACEデータセンターに出向き,心血管疾患・婦人科癌の発症に関連する生活保健習慣および生殖機能関連のリスク因子について,ライフコース疫学的な解析を行い検討する。また,3つのグループ(本邦女性,欧米豪に在住の日系女性・アジア系女性,その他の欧米豪の女性)の比較から,本邦女性やアジア系女性の健康における環境要因の影響の大きさを評価する。

Outline of Final Research Achievements

The collaborative study with the global women's cohort consortium (InterLACE), which includes the Japan Nurses' Health Study, reported epidemiological findings on the association between reproductive health and non-communicable diseases in women. The main findings published in international medical journals include: 1) Women who undergo early menopause have a higher risk of developing cardiovascular disease before age 60; 2) Women who have a short reproductive period, early menarche, and early menopause have a higher risk of cardiovascular disease; 3) Women who have experienced infertility or frequent miscarriages or stillbirths have a higher risk of developing stroke later in life; 4) Women who have experienced infertility, miscarriages or stillbirths have a higher risk of early menopause, with this tendency being particularly strong in Asian women.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は,世界最大規模の国際コンソーシアム「生殖機能関連事象と慢性疾患イベントに関するライフコース・アプローチの国際共同研究(InterLACE)」と「日本ナースヘルス研究(JNHS)」の長期観察データを共同で統合解析することで得られたものである。いずれの原著論文も高インパクトをもつ国際医学雑誌に掲載され,公表後には頻回に引用参照されている。本研究において,世界の女性での健康事象のライフコース疫学的な分析から,民族・人種間の共通点と相違点を検討することで,本邦女性そして世界の女性の健康増進に何が寄与してきたのか,部分的ながらも明らかにすることができた。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (16 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (5 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (1 results) (of which Invited: 1 results) Remarks (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] クイーンズランド大学(オーストラリア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] クイーンズランド大学(オーストラリア)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] クイーンズランド大学(オーストラリア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] クイーンズランド大学(オーストリア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Queensland(オーストラリア)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies2023

    • Author(s)
      Chung Hsin-Fang、Dobson Annette J.、Hayashi Kunihiko、Hardy Rebecca、Kuh Diana、Anderson Debra J.、van der Schouw Yvonne T.、Greenwood Darren C.、Cade Janet E.、Demakakos Panayotes、Brunner Eric J.、Eastwood Sophie V.、Sandin Sven、Weiderpass Elisabete、Mishra Gita D.
    • Journal Title

      Diabetes Care

      Volume: 46 Issue: 11 Pages: 2024-2034

    • DOI

      10.2337/dc23-1209

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is there a link between infertility, miscarriage, stillbirth, and premature or early menopause? Results from pooled analyses of nine cohort studies2023

    • Author(s)
      Liang Chen、Chung Hsin-Fang、Dobson Annette J.、Cade Janet E.、Greenwood Darren C.、Hayashi Kunihiko、Hardy Rebecca、Kuh Diana、Van der schouw Yvonne T.、Sandin Sven、Weiderpass Elisabete、Mishra Gita D.
    • Journal Title

      American Journal of Obstetrics and Gynecology

      Volume: - Issue: 1 Pages: 47.e1-47.e9

    • DOI

      10.1016/j.ajog.2023.04.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618?851 women2022

    • Author(s)
      Liang Chen、Chung Hsin-Fang、Dobson Annette J、Hayashi Kunihiko、van der Schouw Yvonne T、Kuh Diana、Hardy Rebecca、Derby Carol A、El Khoudary Samar R、Janssen Imke、Sandin Sven、Weiderpass Elisabete、Mishra Gita D
    • Journal Title

      BMJ

      Volume: - Pages: e070603-e070603

    • DOI

      10.1136/bmj-2022-070603

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence and factors associated with overactive bladder and stress urinary incontinence in the Japan Nurses’ Health Study2021

    • Author(s)
      Nagai Kazue、Homma Yukio、Ideno Yuki、Hayashi Kunihiko
    • Journal Title

      Menopause

      Volume: 29 Issue: 2 Pages: 129-136

    • DOI

      10.1097/gme.0000000000001893

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Reproductive Life Span and Incident Nonfatal Cardiovascular Disease2020

    • Author(s)
      Mishra SR, Chung HF, Waller M, Dobson AJ, Greenwood DC, Cade JE, Giles GG, Bruinsma F, Simonsen MK, Hardy R, Kuh D, Gold EB, Crawford SL, Derby CA, Matthews KA, Demakakos P, Lee JS, Mizunuma H, Hayashi K, Sievert LL, Brown DE, Sandin S, Weiderpass E, Mishra GD.
    • Journal Title

      JAMA Cardiology

      Volume: 5 Issue: 12 Pages: 1410-1410

    • DOI

      10.1001/jamacardio.2020.4105

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data.2019

    • Author(s)
      Zhu D, Chung HF, Dobson AJ, Pandeya N, Giles GG, Bruinsma F, Brunner EJ, Kuh D, Hardy R, Avis NE, Gold EB, Derby CA, Matthews KA, Cade JE, Greenwood DC, Demakakos P, Brown DE, Sievert LL, Anderson D, Hayashi K, Lee JS,et al
    • Journal Title

      The Lancet Public Health

      Volume: 4 Issue: 11 Pages: e553-e564

    • DOI

      10.1016/s2468-2667(19)30155-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] JNHS研究の目的、計画、そしてその知見.シンポジウム「大規模コホート研究が導く人生100年時代の助産ケア」2020

    • Author(s)
      林邦彦
    • Organizer
      第34回日本助産学会学術集会(新潟、インターネット学術集会)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Remarks] JNHS 日本ナースヘルス研究 「女性の生活習慣と健康に関する疫学研究」

    • URL

      https://plaza.umin.ac.jp/~jnhs/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 日本ナースヘルス研究(Japan Nurses’ Health Study;JNHS)

    • URL

      https://plaza.umin.ac.jp/~jnhs/

    • Related Report
      2022 Research-status Report
  • [Remarks] 日本ナースヘルス研究(JNHS)

    • URL

      https://plaza.umin.ac.jp/~jnhs

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] InterLACE-JNHS Joint Meeting2024

    • Related Report
      2023 Annual Research Report

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Published: 2019-10-10   Modified: 2025-01-30  

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