| Project/Area Number |
20249068
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
ITO Juichi Kyoto University, 医学研究科, 教授 (90176339)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Takayuki 京都大学, 医学研究科, 講師 (50335270)
HIRAUMI Harukazu 京都大学, 医学研究科, 助教 (10374167)
YAMAMOTO Norio 京都大学, 医学研究科, 助教 (70378644)
SAKAMOTO Tatsunori 京都大学, 医学研究科, 助教 (60425626)
KOJIMA Ken 京都大学, 医学研究科, 客員研究員 (60378685)
TAURA Akiko 京都大学, 医学研究科, 助教 (70515345)
KITAJIRI Shinichiro 京都大学, 医学研究科, 助教 (00532970)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2010: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2008: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Keywords | 再生医学 / 発生学 / 細胞増殖 / 転写因子 / 幹細胞 / 支持細胞 / 有毛細胞 |
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| Research Abstract |
In this research we found several factors that are important for inner ear development contributed to regenerative medicine of inner ears. Silencing of p27Kip1, cell cycle dependent kinase inhibitor, caused proliferation of postnatal mammalian cochlear supporting cell that had been considered to be non-proliferative. HGF and EP4 agonist protected or treated inner ear disorders including noise induced hearing loss and hearing loss due to aminoglycoside treatment. We also identified downstream mechanisms of how these molecules affect on inner ear hair cells. In addition novel roles of Notch signaling in inner ear development. Notch signaling not only specifies cell fates between inner ear hair and supporting cells but also regulates timing of differentiation of sensory epithelial progenitors and maintains those cell population.
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