A novel targeting DDS for the treatment of autoimmune diseases and allergy
| Project/Area Number |
20390014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
OKU Naoto University of Shizuoka, 薬学部, 教授 (10167322)
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| Co-Investigator(Kenkyū-buntansha) |
ASAI Tomohiro 静岡県立大学, 薬学部, 講師 (00381731)
SHIMIZU Kosuke 静岡県立大学, 薬学部, 助教 (30423841)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ドラッグデリバリー / DDS / 逆標的化 / リポソーム / アレルギー / 花粉症 / 免疫疾患 / ABC現象 / Cryj1 / Cryj 1 / Cryjl |
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| Research Abstract |
Specific antigen-sensitized body has the antigen-specific immune cells, which recognize the antigen. The antigen-coupled carrier is recognized by the immune cells. When the carrier encapsulate certain drugs, these drugs are specifically delivered to the immune cells. This strategy would be useful for suppressing the activity of specific immune cells related allergy and other immune diseases.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008
Author(s)
Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
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Journal Title
Int.J.Pharm 362
Pages: 197-200
Related Report
Peer Reviewed
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