Effect of estrogen deficiency on the development of autoimmune diseases
| Project/Area Number |
20390479
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARAKAKI Rieko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (00193061)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMARU Naozumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60314879)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 自己免疫疾患 / シェーグレン症候群 / 性差 / エストロゲン / Th17細胞 / 性ホルモン / 唾液腺 / アポトーシス / 発現制御 |
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| Research Abstract |
Although a number of autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmunity remain unclear. We show that estrogen deficiency induces apoptotic cells and enhances the inflammatory lesion, plasmacytoid dendritic cells and Th17 cells in the salivary glands of NOD mice. Estrogen deficiency may paly a possible role for gender-based autoimmunity in postmenopausal women.
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Report
(4 results)
Research Products
(51 results)
