Mechanisms and roles on phagocytosis of microbes and altered self cells

• Project/Area Number: 20570127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kanazawa University
• Principal Investigator: SHIRATSUCHI Akiko Kanazawa University, 薬学系, 准教授 (90303297)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞貪食 / 微生物 / 自然免疫 / Drosophila / マクロファージ / アポトーシス / 感染症 / ショウジョウバエ / 炎症

Research Abstract

Elimination of unwanted cells by phagocytosis is the cellular innate immunity, and its molecular mechanism and role have remained to be elucidated. In this study, we found out the intracellular signaling through Draper, a phagocytic receptor we have detected. We also identified Draper ligand in Drosophila apoptotic cells and bacteria, and suggested that the phagocytic receptor in innate immunity acts as a multi ligand-receptor. On the other hand, we identified bacterial factors that influenced with host cellular and humoral immunity, and examined bacterial strategy to escape from the host immune responses.

Research Products

• [Journal Article] (review)Phagocytic removal of cells that have become unwanted : implications for animal development and tissue homeostasis. (2011)
  • Author(s): Nakanishi, Y., Nagaosa, K., Shiratsuchi, A.
  • Journal Title: Develop.Growth Differ. Pages: 149-160
  • Peer Reviewed
• [Journal Article] Phagocytic removal of cells that have become unwanted : implications for animal development and tissue homeostasis (2011)
  • Author(s): Nakanishi, Y., Nagaosa, K., Shiratsuchi.A.
  • Journal Title: Develop.Growth Differ Volume: 53 Pages: 149-160
  • NAID: 10027899728
  • Peer Reviewed
• [Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus. (2010)
  • Author(s): Tabuchi, Y., Shiratsuchi, A., Kurokawa, K., Gong, J.H., Sekimizu, K., Lee, B.L., Nakanishi, Y.
  • Journal Title: J.Immunol. 185 Pages: 2424-2431
  • Peer Reviewed
• [Journal Article] Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages. (2010)
  • Author(s): Shiratsuchi, A., Shimizu, K., Watanabe, I., Hashimoto, Y., Kurokawa, K., Razanajatovo, I.M., Park, K.H., Park H.K., Lee, B.L., Sekimizu, K., Nakanishi, Y.
  • Journal Title: Immunololgy 129 Pages: 268-277
  • NAID: 120001828365
  • Peer Reviewed
• [Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus (2010)
  • Author(s): Tabuchi, Shiratsuchi, A., Kurokawa, K.Gong, J.H.,Sekimizu, K, Lee, B.L.,Nakanishi, Y.
  • Journal Title: J.Immunol Volume: 185 Pages: 2424-2431
  • Peer Reviewed
• [Journal Article] Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages (2010)
  • Author(s): Shiratsuchi, A., Shimizu, K, Watanabe, I., Hashimoto, Y, Kurokawa, K., Razanajatovo, I.M., Park, K.H., Park H.K., Lee, B.L., Sekimizu.K., Nakanishi, Y
  • Journal Title: Immunololgy Volume: 129 Pages: 268-277
  • NAID: 120001828365
  • Peer Reviewed
• [Journal Article] アポトーシス依存的な細胞食食による生体恒常性の維持 (2010)
  • Author(s): 且土墜圧, 中西義信
  • Journal Title: 実験医学(増刊)「細胞死研究総集編」 Volume: 28 Pages: 1055-1061
• [Journal Article] Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages (2010)
  • Author(s): Shiratsuchi, A., Shimizu, K., Watanabe, I., Hashimoto, Y., Kurokawa, K., Razanajatovo, I.M., Park, H.H., Park, H.K., Lee, B.L., Sekimizu, K., Nakankshi, Y.
  • Journal Title: Immunology (in press)
  • NAID: 120001828365
  • Peer Reviewed
• [Journal Article] アポトーシス依存的な細胞貪食による生体恒常性の維持 (2010)
  • Author(s): 白土明子, 中西義信
  • Journal Title: 実験医学 (印刷中)
• [Journal Article] Identification of lipoteichoic acid as a ligand for Draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. (2009)
  • Author(s): Hashimoto, Y., Tabuchi, Y., Sakurai, K., Kutsuna, M., Kurokawa, K., Awasaki, T., Sekimizu, K., Nakanishi, Y., Shiratsuchi, A.
  • Journal Title: J.Immunol. 183 Pages: 7451-7460
  • Peer Reviewed
• [Journal Article] Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells. (2009)
  • Author(s): Kuraishi, T., Nakagawa, Y., Nagaosa, K., Hashimoto, Y., Ishimoto, T., Moki, T., Fujita, Y., Nakayama, H., Dohmae, N., Shiratsuchi, A., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki, T., Nakanishi, Y.
  • Journal Title: EMBO J. 28 Pages: 3668-3878
  • Peer Reviewed
• [Journal Article] Signaling pathway involving GULP, MAPK, and Racl for SR-BI-induced phagocytosis of apoptotic cells. (2009)
  • Author(s): Osada, Y., Sunatani, T., Kim, I.-S., Nakanishi, Y., Shiratsuchi, A.
  • Journal Title: J.Biochem. 145 Pages: 387-394
  • Peer Reviewed
• [Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Racl and Cdc42. (2009)
  • Author(s): Shiratsuchi, A., Ichiki, M., Okamoto, Y., Ueda, N., Sugimoto, N., Takuwa, Y., Nakanishi, Y.
  • Journal Title: J.Biochem. 145 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells (2009)
  • Author(s): Kuraishi, T, Nakagawa, Y., Nagaosa, K., Hashimoto, Y., Ishimoto, T., Moki, T., Fujita, Y., Nakayama, H., Dohmae, N., Shiratsuchi, A., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki, T., Nakanishi, Y.
  • Journal Title: EMBO J. 28 Pages: 3868-3878
  • Peer Reviewed
• [Journal Article] Lipoteichoic acid-dependent, Draper-mediated phagocytosis of Staphylococcus aureus by Drosophila hemocytes (2009)
  • Author(s): Hashimoto, Y., Tabuchi, Y., Sakurai, K., Kutsuna, M., Kurokawa, K., Awasaki, T., Sekimizu, K., Nakanishi, Y., Shiratsuchi, A.
  • Journal Title: J.Immunol. 183 Pages: 7451-7460
  • Peer Reviewed
• [Journal Article] The triacylated ATP binding cluster transporter substrate-binding lipoprote in of Staphylococcus aureus functions as a native ligand for the toll-like receptor 2 (2009)
  • Author(s): Kurokawa, K., Lee, H., Rho, K.-B., Asanuma, M., Kim, Y.S., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, H.J., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., Lee.B.-L.
  • Journal Title: J.Biol.Chem. 284 Pages: 8406-8411
  • Peer Reviewed
• [Journal Article] Signaling pathway involving GULP, MAPK, and Racl for SR-BI-induced phagocytosis of apoptotic cells (2009)
  • Author(s): Osada, Y., Sunatani, Y., Kim, I-S., Nakanishi, Y., Shiratsuchi, A.
  • Journal Title: J.Biochem. 145 Pages: 387-394
  • Peer Reviewed
• [Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42 (2009)
  • Author(s): Shiratsuchi, A., Ichiki, M., Okamoto, Y., Ueda, N., Sugimoto, N., Takuwa, Y., Nakanishi, Y.
  • Journal Title: J.Biochem. 145 Pages: 43-50
  • NAID: 10024914309
  • Peer Reviewed
• [Journal Article] Study on the mechanism and role of phagocytic elimination of microbes and microbe-infected cells (2009)
  • Author(s): 白土明子
  • Journal Title: J.Juzen Med.Soc 118 Pages: 9-12
  • NAID: 10026960859
• [Journal Article] リン脂質を介したアポトーシス細胞の貪食除去 (2009)
  • Author(s): 白土明子, 中西義信
  • Journal Title: オレオサイエンス 9 Pages: 465-472
• [Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Racl and Cdc42. (2009)
  • Author(s): Shiratsuchi, A., Ichiki, M., Okamoto, Y., Ueda, N., Sugimoto, N., Takuwa, Y., Nakanishi, Y.
  • Journal Title: J Biochem. 145 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Signaling pathway involving GULP, MAPK, and Racl for SR-BI-induced phagocytosis of apoptotic cells. (2009)
  • Author(s): Osada, Y., Sunatani, Y., Kim, IS., Nakanishi, Y., Shiratsuchi. A.
  • Journal Title: J. Biochem. 145(in press)
  • Peer Reviewed
• [Journal Article] The triacylated ATP binding cluster transporter substrate-binding lipopr otein of Staphylococcus aureus functions as a native ligand for the toll-like receptor 2. (2009)
  • Author(s): Kurokawa. K., Lee, H., Rlio. K. -B., Asanuma, M., Kim, Y. S., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, H. J., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., Lee, B. -L.
  • Journal Title: J. Biol. Chem. (in press)
  • Peer Reviewed
• [Journal Article] Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli. (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ju, J.-S., Lee, B.-L., Nakanishi, Y.
  • Journal Title: Immunology 124 Pages: 575-583
  • NAID: 120000807242
  • Peer Reviewed
• [Journal Article] Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Yoshida, H., Nakanishi, Y.
  • Journal Title: Immunol. Cell Biol. 86 Pages: 179-184
  • Peer Reviewed
• [Journal Article] Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. (2008)
  • Author(s): Shiratsuchi, A., Watanabe. I., Yoshida, H., Nakanishi, Y
  • Journal Title: Immunol. Cell. Biol. 86 Pages: 179-184
  • Peer Reviewed
• [Journal Article] Bridging effect of recombinant human mannose-binding lectin in macro phage phagocytosis of Eschericha coli. (2008)
  • Author(s): Shiratsuchi. A., Watanabe, I., Ju, J. -S., Lee, B. -L., Nakanishi, Y.
  • Journal Title: Immunology 124 Pages: 575-583
  • Peer Reviewed
• [Presentation] ショウジョウバエヘモサイトによるインテグリンを介する黄色ブドウ球菌の食機構 (2010)
  • Author(s): 白士明子, 桜井漣次, 森俊暢, 中西義信
  • Organizer: 第83回日本生化学会大会・第33回分ヰ生物学会年会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2010-12-08
• [Presentation] ショウジョウバエインテグリンによる黄色ブドウ球菌の貪食 (2010)
  • Author(s): 桜井健次, 中西義信, 白土明子
  • Organizer: 日本生化学会北陸支部会第27回大会
  • Place of Presentation: 福井大学(福井県)
  • Year and Date: 2010-05-29
• [Presentation] ショウジョウバエインテグリンによる黄色ブドウ球菌の食食 (2010)
  • Author(s): 桜井健次, 中西義信, 白士明子
  • Organizer: 日本生化学会北陸支部第27回大会
  • Place of Presentation: 福井大学文京キャンパス(福開)
  • Year and Date: 2010-05-29
• [Presentation] ショウジョウバエヘモサイトによるインテグリンを介する黄色ブドウ球菌の貪食機構 (2010)
  • Author(s): 白土明子, 桜井健次, 森俊暢, 中西義信
  • Organizer: 第83回日本生化学会大会・第33回分子生物学会年会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] リポタイコ酸と Draper を介したショウジョウバエヘモサイトによる黄色ブドウ球菌の貪食 (2009)
  • Author(s): 橋本優実, 田淵幸幾, 黒川健児, 粟崎健, 関水和久, 中西義信, 白土明子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド (兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] 黄色ブドウ球菌のD-アラニン化壁タイコ酸にるショウジョウバエでの抗菌ペプチド産生の抑制 (2009)
  • Author(s): 田淵幸幾, 櫻井健次, 久綱真由美, 黒川健児, Bok Luel Lee, 関水和久, 中西義信, 白土明子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド (兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] N-パルミトイルホスファチジルエタノールアミンのマクロファージ貪食抑制効果 (2009)
  • Author(s): 白土明子, 一木万奈美, 岡本安雄, 上田夏生, 杉本直俊, 多久和陽, 中西義信
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド (兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] 実験科学に携わる様々な生き方 (2009)
  • Author(s): 白土明子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド (兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] Draper-mediated phagocytosis of Staphylococcus aureus by Drosophila hemocytes. (2009)
  • Author(s): 橋本優美, 白土明子, 田淵幸幾, 櫻井健次, 黒川健児, 関水和久, 中西義信
  • Organizer: 17 th International Symposium on Molecular Biology of Macrophages
  • Place of Presentation: KKR金沢(石川県)
  • Year and Date: 2009-07-03
• [Presentation] Draper-mediated phagocytosis of Staphylococcus aureus by Drosophila hemocytes (2009)
  • Author(s): Y.Hashimoto, A.Shiratsuchi, Y.Tabuchi, K.Sakurai, K.Kurokawa, K.Sekimizu, Y.Nakanishi
  • Organizer: 17th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: KKR Kanazawa (Ishikawa)
  • Year and Date: 2009-07-03
• [Presentation] Mechanism and role of phagocytosis of Staphylococcus aureus by Drosophila hemocytes. (2009)
  • Author(s): 白土明子, 橋本優美, 田淵幸幾, 黒川健児, 関水和久, 中西義信
  • Organizer: Gordon Research Conference : Apoptotic Cell Recognition & Clearance
  • Place of Presentation: Colby-Sawyer College(USA)
  • Year and Date: 2009-06-29
• [Presentation] ショウジョウバエヘモサイトによる黄色ブドウ球菌の貪食機構 (2009)
  • Author(s): 橋本優実, 田淵幸幾, 黒川健児, 関水和久, 中西義信, 白土明子
  • Organizer: 日本生化学会北陸支部会第26回大会
  • Place of Presentation: 福井大学(福井県)
  • Year and Date: 2009-05-23
• [Presentation] ショウジョウバエヘモサイトによる黄色ブドウ球菌の貪食機構 (2009)
  • Author(s): 橋本優実, 田淵幸幾, 黒川健児, 関水和久, 中西義信, 白土明子
  • Organizer: 日本生化学会北陸支部第26回大会
  • Place of Presentation: 福井大学文京キャンパス (福井県)
  • Year and Date: 2009-05-23
• [Presentation] リポタイコ酸とDraperを介したショウジョウバエヘモサイトによる黄色ブドウ球菌の貪食 (2009)
  • Author(s): 橋本優美, 田淵幸幾, 黒川健児, 粟崎健, 関水和久, 中西義信, 白土明子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] 黄色ブドウ球菌のD-アラニン化壁タイコ酸によるショウジョウバエでの抗菌ペプチド産生の抑制 (2009)
  • Author(s): 田淵幸幾, 櫻井健次, 久綱真由美, 黒川健児, Lee, BL., 関水和久, 中西義信, 白土明子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] N-パルミトイルホスファチジルエタノールアミンのマクロファージ貪食抑制効果 (2009)
  • Author(s): 白土明子, 一木万奈美, 岡本安雄, 上田夏生, 杉本直俊, 多久和陽, 中西義信
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] Mechanism and role of phagocytosis of Staphylococcus aureus by Drosophila hemocytes (2009)
  • Author(s): A.Shiratsuchi, Y.Hashimoto, Y.Tabuchi, K.Kurokawa, K.Sekimizu, Y.Nakanishi
  • Organizer: Gordon Research Conference : Apoptotic Cell Recognition & Clearance, 'Worm-Fly-Vertebrate-Human Clearance And Failure'
  • Place of Presentation: Colby-Sawyer College, NH (USA)
• [Presentation] Search for Staphylococcus aureus genes modulating innate immune responses in Drosophila. (2008)
  • Author(s): 白土明子, 田淵幸幾, 橋本優実, 黒川健児, 関水和久, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-12-12
• [Presentation] Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli. (2008)
  • Author(s): 中西義信, 渡辺郁子, Bok Luel Lee, 白土明子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-12-12
• [Presentation] Involvement of GULP and Racl in scavenger receptor class B type I-mediated phagocytosis of apoptotic cells (2008)
  • Author(s): 長田洋一, 砂谷俊郎, 白土明子, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-12-10
• [Presentation] A role for Drosophila Ced-6 in phagocytosis of apoptotic cells. (2008)
  • Author(s): 倉石貴透, 真中純子, 粟崎健, 中川祐紀子, 荒井國三, 岡田亮, 白土明子, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-12-09
• [Presentation] Mechanism of Draper-mediated phagocytosis of Staphylococcus aureus in Drosophila. (2008)
  • Author(s): 橋本優実, 田淵幸幾, 黒川健児, 粟崎健, 関水和久, 中西義信, 白土明子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-12-09
• [Presentation] 哺乳類精巣でのアポトーシス細胞貪食の機構と意義 (2008)
  • Author(s): 白土明子
  • Organizer: 第17回アポトーシス研究会学術集会:シンポジウム:生殖・内分泌系のアポトーシス
  • Place of Presentation: 京都めるぱるく(京都府)(招待講演)
  • Year and Date: 2008-08-01
• [Presentation] 哺乳類精巣でのアポトーシス細胞貪食の機構と意義 (2008)
  • Author(s): 白土明子
  • Organizer: 第17回アポトーシス研究会学術集会 : シンポジウム : 生殖・内分泌系のアポトーシス(招待講演)
  • Place of Presentation: 京都めるぱるく(京都市)
  • Year and Date: 2008-08-01
• [Presentation] Pretaporter, a Drosophila endoplasmic reticulum protein serving as a ligand for Draper in phagocytosis ofapoptotic cells. (2008)
  • Author(s): Kuraishi, T., Ishimoto, T., Moki, T., Nakagawa, Y., Nakayama, H., Shiratsuchi, A., Hashimoto, Y., Ueada, K., Yamaguthi, M., Awasaki, T., Moki, T., Nakanishi, Y.
  • Organizer: 7th International Cell Death Society Symposium
  • Place of Presentation: Shanghai, China
  • Year and Date: 2008-06-12
• [Presentation] Characterization of CG1837 protein as a candidate ligand for Draper, a Drosophila phagocytosis receptor. (2008)
  • Author(s): Kuraishi, T., Ishimoto, T., Yamamoto, N., Ueda, K., Nakayama, H., Yamaguthi, M., Awasaki, T., Hashimoto, Y., Moki, T., Shiratsuchi, A., Nakanishi, Y.
  • Organizer: 49 th Annual Drosophila Research Conference
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2008-04-10
• [Presentation] ショウジョウバエ自然免疫応答を調節する黄色ブドウ球菌遺伝子の探索 (2008)
  • Author(s): 白土明子, 田淵幸幾, 橋本優実, 黒川健児, 関水和久, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] スカベンジャー受容体クラスBタイプIを介するアポトーシス細胞貪食へのGULPとRaclの関与 (2008)
  • Author(s): 長田洋一, 砂谷俊郎, 白土明子, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] ショウジョウバエCed-6のアポトーシス細胞貪食における役割 (2008)
  • Author(s): 倉石貴透, 真中純子, 粟崎健, 中川祐紀子, 荒井國三, 岡田亮, 白土明子, 中西義信
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] ショウジョウバエにおけるDraperを介した黄色ブドウ球菌の貪食機構 (2008)
  • Author(s): 橋本優美, 田淵幸幾, 黒川健児, 粟崎健, 関水和久, 中西義信, 白土明子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] ヒト組換え型マンノース結合レクチンの橋渡し効果による大腸菌貪食の促進 (2008)
  • Author(s): 中西義信, 渡辺郁子, Lee, BL., 白土明子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] Pretaporter, a Drosophila endoplasmic reticulum protein serving as a ligand for Draper in phagocytosis of apoptotic cells. (2008)
  • Author(s): Kuraishi T., Ishimoto, T., Moki, T., Nakagawa Y., Nakayama, H., Shiratsuchi A., Hashimoto Y., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki T., Nakanishi Y.
  • Organizer: 7th International Cell Death Society Symposium
  • Place of Presentation: Shanghai National Accounting Institute(China)
• [Presentation] Characterization of CG1837 protein as a candidate ligand for Draper, a Drosophila phagocytosis receptor. (2008)
  • Author(s): Kuraishi T., Ishimoto, Y., Yamamoto, N., Ueda, K., Nakayama, H., Yamaguchi, M., Awasaki Y., Hashimoto Y., Moki, T., Shiratsuchi A., Nakanishi Y.
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: Town & Country Resort and Convention Center(USA)
• [Book] Pattern recognition in phagocytic clearance of altered self. In : Target Pattern Recognition in Innate Immunity (2009)
  • Author(s): Nakanishi, Y., Henson, P.M., Shiratsuchi, A.
  • Total Pages: 5
  • Publisher: Landes Bioscience, Austin
• [Remarks] ホームページ等 ウエブサイト
  • URL: http://www.p.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/~seibutu/index.html