2010 Fiscal Year Final Research Report
Mechanisms and roles on phagocytosis of microbes and altered self cells
| Project/Area Number |
20570127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SHIRATSUCHI Akiko Kanazawa University, 薬学系, 准教授 (90303297)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞貪食 / 微生物 / 自然免疫 / Drosophila / マクロファージ |
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| Research Abstract |
Elimination of unwanted cells by phagocytosis is the cellular innate immunity, and its molecular mechanism and role have remained to be elucidated. In this study, we found out the intracellular signaling through Draper, a phagocytic receptor we have detected. We also identified Draper ligand in Drosophila apoptotic cells and bacteria, and suggested that the phagocytic receptor in innate immunity acts as a multi ligand-receptor. On the other hand, we identified bacterial factors that influenced with host cellular and humoral immunity, and examined bacterial strategy to escape from the host immune responses.
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Research Products
(26 results)
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[Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus.2010
Author(s)
Tabuchi, Y., Shiratsuchi, A., Kurokawa, K., Gong, J.H., Sekimizu, K., Lee, B.L., Nakanishi, Y.
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Journal Title
J.Immunol. 185
Pages: 2424-2431
Peer Reviewed
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[Journal Article] Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages.2010
Author(s)
Shiratsuchi, A., Shimizu, K., Watanabe, I., Hashimoto, Y., Kurokawa, K., Razanajatovo, I.M., Park, K.H., Park H.K., Lee, B.L., Sekimizu, K., Nakanishi, Y.
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Journal Title
Immunololgy 129
Pages: 268-277
Peer Reviewed
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[Journal Article] Identification of lipoteichoic acid as a ligand for Draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes.2009
Author(s)
Hashimoto, Y., Tabuchi, Y., Sakurai, K., Kutsuna, M., Kurokawa, K., Awasaki, T., Sekimizu, K., Nakanishi, Y., Shiratsuchi, A.
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Journal Title
J.Immunol. 183
Pages: 7451-7460
Peer Reviewed
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[Journal Article] Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells.2009
Author(s)
Kuraishi, T., Nakagawa, Y., Nagaosa, K., Hashimoto, Y., Ishimoto, T., Moki, T., Fujita, Y., Nakayama, H., Dohmae, N., Shiratsuchi, A., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki, T., Nakanishi, Y.
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Journal Title
EMBO J. 28
Pages: 3668-3878
Peer Reviewed
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[Journal Article] Signaling pathway involving GULP, MAPK, and Racl for SR-BI-induced phagocytosis of apoptotic cells.2009
Author(s)
Osada, Y., Sunatani, T., Kim, I.-S., Nakanishi, Y., Shiratsuchi, A.
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Journal Title
J.Biochem. 145
Pages: 387-394
Peer Reviewed
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[Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Racl and Cdc42.2009
Author(s)
Shiratsuchi, A., Ichiki, M., Okamoto, Y., Ueda, N., Sugimoto, N., Takuwa, Y., Nakanishi, Y.
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Journal Title
J.Biochem. 145
Pages: 43-50
Peer Reviewed
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[Presentation] Pretaporter, a Drosophila endoplasmic reticulum protein serving as a ligand for Draper in phagocytosis of apoptotic cells.2008
Author(s)
Kuraishi T., Ishimoto, T., Moki, T., Nakagawa Y., Nakayama, H., Shiratsuchi A., Hashimoto Y., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki T., Nakanishi Y.
Organizer
7th International Cell Death Society Symposium
Place of Presentation
Shanghai National Accounting Institute(China)
Year and Date
20080606-20080609
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[Presentation] Characterization of CG1837 protein as a candidate ligand for Draper, a Drosophila phagocytosis receptor.2008
Author(s)
Kuraishi T., Ishimoto, Y., Yamamoto, N., Ueda, K., Nakayama, H., Yamaguchi, M., Awasaki Y., Hashimoto Y., Moki, T., Shiratsuchi A., Nakanishi Y.
Organizer
49th Annual Drosophila Research Conference
Place of Presentation
Town & Country Resort and Convention Center(USA)
Year and Date
20080402-20080406
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