Signaling cross-talk between G protein-coupled receptor and tetraspanin in tumor inflammatory microenvironment
| Project/Area Number |
20590363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
FURUYA Mitsuko Yokohama City University, 医学部, 准教授 (10361445)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Reiko 千葉大学, 真菌研究医学ンター, 助教 (60143319)
米満 吉和 千葉大学, 大学院・医学研究院, 教授 (40315065)
木村 定雄 千葉大学, 医学研究院, 教授 (40134225)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子病理 / 腫瘍 / 4回膜貫通蛋白質 / G蛋白質 / シグナル / クロストーク |
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| Research Abstract |
The difference of inflammatory microenvironment between ovarian cancers and endometriosis was investigated. We detected three CXCR3 variants in human tissues. Quantitative analyses revealed differential expressions of three variants. CXCR3-alt was upregulated and CXCR3B was downregulated in caners compared with endometriosis. In situ hybridization demonstrated preferential expression of CXCR3B in non-cancerous vessels and CXCR3-alt was detectable mainly in tumor vessels. Collective data suggest that differential expression patterns of CXC chemokines and CXCR3 variants are involved in inflammatory microenvironments of ovarian cancers and cancer-associated conditions.
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Report
(4 results)
Research Products
(72 results)
