Study in the effects of IBM-BMT using parabiotic mice
| Project/Area Number |
20590413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
INABA Muneo Kansai Medical University, 医学部, 准教授 (70115947)
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| Co-Investigator(Kenkyū-buntansha) |
HISHA Hiroko 関西医科大学, 医学部, 講師 (90151422)
MAKI Masahiko 関西医科大学, 医学部, 講師 (80297001)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 並体結合マウス / 骨髄移植 / 樹状細胞 / 造血幹細胞 / 循環動態 |
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| Research Abstract |
We have prepared the parabiotic mice to compare the efficiency of donor dell engraftment by IBM-BMT with that by IV-BMT in the physiological condition. BMCs from GFP mice were transplanted into C57BL/6 mice by IBM-BMT ([GFP->C57BL/6]^<IBM-BMT>), and the parabiotic mouse was made up of the ([GFP->C57BL/6]^<IBM-BMT> mouse and normal C57BL/6 mouse ([GFP→C57BL/6]^<IBM-BMT>+C57BL/6). In this mouse, the frequency of hemopoietic progenitor cells, defined as Lin^-/c-kit^+ cells, was significantly higher than that determined in the ([GFP→C57BL/6]^<IV-BMT>+C57BL/6 mouse, indicating the efficiency of donor cell engraftment by IBM-BMT.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Interferon-□ and interleukin-12 are induced, respectively, by doublestranded DNA and single-stranded RNA in human myeloid dendritic cells.2011
Author(s)
Katashiba Y., Miyamoto R., Hyo A., Shimamoto K., Murakami N., Ogata M., Amakawa R., Inaba M., Nomura S., Fukuhara S., Ito T.
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Journal Title
Immunology 132
Pages: 165-173
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Peer Reviewed
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[Journal Article] Preferential expansion of human umbilical cord blood-derived CD34-positive cells on major histocompatibility complex-matched amnion-derived mesenchymal stem cells.2009
Author(s)
Mizokami T., Hisha H., Okazaki S., Takaki T., Wang X., Song, C., Li Q., Kato J., Hosaka N., Inaba M., Kanzaki H., Ikehara S.
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Journal Title
Haematologica-The hematology Journal 94
Pages: 618-628
Related Report
Peer Reviewed
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[Journal Article] Contribution of neural cell adhesion molecule (NCAM) to hemopoietic system in monkeys.2008
Author(s)
Kato J., Hisha H., Wang X.-I., Mizokami T., Okazaki S., Li Q., Song C., Maki M.,Hosaka N., Adachi Y., Inaba M., Ikehara S.
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Journal Title
Ann.Hematol. 87
Pages: 797-807
Related Report
Peer Reviewed
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[Journal Article] Long-term donor-specific tolerance in rat cardiac allografts by intrabone marrow injection of donor bone marrow cells.2008
Author(s)
Guo K., Inaba M., Li M., An J., Cui W., Song C., Wang J., Cui Y., Sakaguchi Y., Tsuda M., Omae M., Ando Y., Li Q., Wang X., Ikehara S.
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Journal Title
Transplantation. 85
Pages: 93-101
Related Report
Peer Reviewed
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[Presentation] The role of dendritic cell subsets in 2,4,6-trinitrobenzene sulfonic acidinducedileitis.2010
Author(s)
Inaba M., Hoshino S., Iwai H., Ito T., Li M., Gershwin M. E., Okazaki K., Ikehara S.
Organizer
14^<th> International Congress of Immunology
Place of Presentation
神戸ポートピアホテルおよび神戸国際展示場(神戸コンベンションセンター), Kobe, Japan
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