Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..
| Project/Area Number |
20590414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
YAMADA Naoko Hyogo College of Medicine, 医学部, 講師 (10319858)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Nobuyuki 兵庫医科大学, 医学部, 教授 (50150339)
NAKASHO Keiji 兵庫医科大学, 医学部, 教授 (00217712)
OHYAMA Hideki 兵庫医科大学, 医学部, 准教授 (90280685)
YAMANEGI Koji 兵庫医科大学, 医学部, 講師 (00434944)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腫瘍 / インターロイキン18 / 転移 / 骨肉腫 |
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| Research Abstract |
IL-18 shows an anti-tumor action through activation of T cells and natural killer cells. We found another action of IL-18, i.e., the inhibition of metastasis by inducing the factor(s) in serum which suppresses the tumor cell mobility. In this study, we aimed to identify the tumor-cell migration inhibitory factor(s). We have revealed that IL-18 induces the factor(s) in not only serum but also the cell lysate of the liver and lung and that the factor(s) is a protein of molecular weight of less than 30,000 daltons. We have also found several candidates for the factor(s).
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.2010
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Nishioka T, Fukunaga S, Futani H, Okamura H, Terada N
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Journal Title
Oncol Rep. 24(6)
Pages: 1621-7
Related Report
Peer Reviewed
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[Journal Article] Fibroblasts stimulated via HLA-II molecules produce prostaglandin E(2) and regulate cytokine production from helper T cells.2010
Author(s)
Kato-Kogoe N, Ohyama H, Nishimura F, Meguro M, Yoshizawa S, Okada Y, Nakasho K, Yamanegi K, Yamada N, Hata M, Higashi T, Terada N, Matsushita S
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Journal Title
Lab Invest. 90(12)
Pages: 1747-56
Related Report
Peer Reviewed
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[Journal Article] Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosar coma cells to NK cell-mediated cytotoxicity.2010
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Terada N, et al.
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Journal Title
Oncol Rep.
Volume: 24
Pages: 1621-7
Related Report
Peer Reviewed
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[Journal Article] Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha- galactosylceramide and interleukin-18.2008
Author(s)
Nishio S, Yamada N, Ohyama H, Yamanegi K, Nakasho K, Hata M, Nakamura Y, Fukunaga S, Futani H, Yoshiya S, Ueda H, Taniguchi M, Okamura H, Terada N
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Journal Title
Cancer Sci. 99(1)
Pages: 113-120
Related Report
Peer Reviewed
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[Journal Article] Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death.2008
Author(s)
Yamanegi K, Yamane J, Hata M, Ohyama H, Yamada N, Kato-Kogoe N, Futani H, Nakasho K, Okamura H, Terada N
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Journal Title
J Cancer Res Clin Oncol. 135(7)
Pages: 879-889
Related Report
Peer Reviewed
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