Study on pathogenesis of pneumoconiosis by exposure to igusa-sendo and diatomite dust and its prevention
| Project/Area Number |
20590604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kumamoto University |
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Principal Investigator |
HARADA Koichi Kumamoto University, 大学院・生命科学研究部, 教授 (00094029)
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| Co-Investigator(Kenkyū-buntansha) |
WEI Chan-Nian 熊本大学, 大学院・生命科学研究部, 准教授 (00363523)
MINAMOTO Keiko 熊本大学, 大学院・生命科学研究部, 助教 (00381012)
UEDA Atsushi 熊本大学, 大学院・生命科学研究部, 名誉教授 (10040198)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | じん肺 / 染土 / 珪藻土 / 肺胞洗浄液 / 感作性 / 発症メカニズム / 粉じん環境調査。 / い草染土 / 疫学調査 / 粉じん環境調査 / 倫理委員会 / 遊離ケイ酸 / 動物実験 / 環境調査 / TNF-α / マクロファージ / リゾチーム活性 |
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| Research Abstract |
To understand pathogenic mechanism of pneumoconiosis due to igusa sendo and diatomite we performed experimental research and environmental study. Macrophage increase in number in the BALF from the animals exposed to igusa send, but it would die or decompose due to the digested diatomite in it. 2-ethylhexyl-4-methoxycinnamate does not provoke contact dermatitis as the usual concentration in commercial cosmetics. Not only wearing wide brimmed hat, but also making up with suntan lotion are thought to be useful measures against sunstroke in igusa planting field. During the environmental study, we find that there are some work places where they weave igusa not treated with muddy sendo soil to make tatami matt. It is understood that the weaving method is the best way to measure the igusa-send dust exposure.
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Report
(4 results)
Research Products
(5 results)
