The association of extracellular matrix metabolism-related gene polymorphisms with hepatic fibrosis progression and hepatocarcinogenesis in HCV chronic liver disease
| Project/Area Number |
20590779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子多型 / C型肝炎 / 肝線維化 / 肝発癌 / 肝細胞癌 / 細胞外マトリックス / TIMP-1 / TIMP-2 / CTGF / 細胞外アトリックス / IL-10 / IL-1β / MMP-3 / IL-1B / TGF-B1 / MMP-1 / C型慢性肝疾患 / MMD-7 / MMP |
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| Research Abstract |
In chronic hepatitis C, the risk of developing hepatocellular carcinoma increases with the progression of liver fibrosis, especially higher in cirrhosis. It is necessary to degrade the surrounding fibrosis matrix of tumor for growth, invasion, and metastasis of malignant tumors, in which matrix metalloproteinases are strongly involved. Recently, functional gene polymorphisms have been identified in matrix metalloproteinases, tissue inhibitors of metalloproteinases and fibrosis-related cytokines. In this study, we analyzed these functional gene polymorphisms as the host genetic factors, and examined the association of these polymorphisms with the severity of liver fibrosis and the prognosis of hepatocellular carcinoma in chronic liver diseases C.
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Report
(6 results)
Research Products
(39 results)
