| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
The study aimed to investigate the role of helix-loop-helix (HLH) transcriptional factor Id1 in angiogenesis. Histological analysis showed that Id1 exhibited a mosaic pattern, mixed with strongly or weakly Id1-expressing ECs during ex vivo and in vivo angiogenesis. Analyses using cultured cells showed that Id1 regulated Dll4-Notch signaling pathway, and that Id1 expression appeared to oscillate periodically, suggesting a possible spatiotemporal regulation of the Notch signaling by Id1 in vascular endothelial cells. Furthermore, we have established a time-lapse imaging and computer-assisted analyzing system, which quantitatively characterizes the cell behavior in angiogenesis.
|
