| Project/Area Number |
20591493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
MASUNAGA Shin-Ichiro Kyoto University, 原子炉実験所, 准教授 (80238914)
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| Co-Investigator(Kenkyū-buntansha) |
KASHINO Genro 京都大学, 原子炉実験所, 助教 (00437287)
TANO Keizo 京都大学, 原子炉実験所, 准教授 (00183468)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 休止期腫瘍細胞 / 癌幹細胞 / 低酸素腫瘍細胞 / 局所腫瘍制御 / 遠隔転移抑制 / 局所腫瘍制御効果 / 遠隔転移抑制効果 / 酸素化休止期腫瘍細胞分画 / p53 status / 硼素中性子捕捉療法(BNCT) / 血管新生阻害剤 / 急性低酸素細胞分画 / 酸素効果 / 線エネルギー付与(LET) / 急性低酸素細胞 / 慢性低酸素細胞 / 線量率効果 / 遠隔転移 / 低温度温熱処置 / ヘキサメチレンテトラミン / 低酸素細胞毒薬剤 / 腫瘍内酸素化状態 / 加速炭素線ビーム |
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| Research Abstract |
Tumor radiosensitivity can be changed through manipulating itratumor oxygenation status not only before and during irradiation but also after irradiation, and not only under high dose-rate but also under reduced dose-rate irradiation. Antiangiogenic agent, bevacizumab, led to releasing intratumor acutely hypoxic fraction, resulting in repressing distant pulmonary metastasis from local tumor. Meanwhile, the method for selectively detecting the sensitivity of oxygenated quiescent tumor cell popiulation could be established.
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