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Brain function and epileptogenecity in human cortical dysplasias

Research Project

Project/Area Number 20591713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSapporo Medical University (2010)
Kyoto University (2008-2009)

Principal Investigator

MIKUNI Nobuhiro  札幌医科大学, 医学部, 教授 (60314217)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  京都大学, 医学研究科, 准教授 (90212761)
MATSUMOTO Riki  京都大学, 医学研究科, 助教 (00378754)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsてんかん / 脳機能 / 皮質形成異常
Research Abstract

We have studied the mechanisms underlying epileptogenesis in cortical dysplasia by using a rat model and a human specimen. The results have shown that excitatory postsynaptic NMDA receptors played a critical role of epilepsy associated with cortical dysplasia. To clarify the mechanisms of human epilepsy, we examined the total protein levels of both NR1 and calmodulin, as well as their coassembly in the human non-epileptogenic cortical areas compared to those in the epileptogenic cortical areas(ictal EEG seizure onset areas as determined by subdural grid electrode recordings). The coassembly of calmodulin and NMDAR1 was decreased in epileptogenic dysplastic cortex compared with normal appearing non-epileptogenic cortex, while there was no significant difference in the total protein levels of calmodulin or NMDAR1 between the two EEG groups. These results suggest that decreased calmodulin-NMDAR1 coassembly is a cellular mechanism that contributes to hyperexcitability in dysplastic cortical neurons and in focal seizure onsets. Reagarding the brain function, epileptic cortical dysplasia have language or motor function which could be compensated following resection.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (64 results)

All 2011 2010 2009 2008

All Journal Article (18 results) (of which Peer Reviewed: 7 results) Presentation (37 results) Book (9 results)

  • [Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential2011

    • Author(s)
      Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO
    • Journal Title

      Hum Brain Mapp.

      Volume: 33 Issue: 12 Pages: 19-19

    • DOI

      10.1002/hbm.21407

    • NAID

      120005555455

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ictal wideband ECoG : Direct comparison between ictal slow shifts and high frequency oscillations2011

    • Author(s)
      Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A
    • Journal Title

      Clin Neurophysiol

      Volume: 122(8) Pages: 1500-1504

    • Related Report
      2010 Final Research Report
  • [Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in thehuman motor system2011

    • Author(s)
      Kikuchi T, Matsumoto R, Mikuni N, Yokoyama Y, Matsumoto A, Ikeda A, Fukuyama H, Miyamoto S, Hashimoto N
    • Journal Title

      Clin Neurophysiol

      Pages: 26-26

    • Related Report
      2010 Final Research Report
  • [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy2011

    • Author(s)
      Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82(6) Pages: 652-657

    • Related Report
      2010 Final Research Report
  • [Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study2011

    • Author(s)
      Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fkuyama H, Takahashi R, Ikeda A
    • Journal Title

      Neuropsychologia

      Volume: 49 Pages: 1350-1354

    • NAID

      120003039178

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intravenous methylprednisolone reduces the risk of propofol-induced adverse effects during Wada testing2010

    • Author(s)
      Mikuni N, Yokoyama Y, Matsumoto A, Kikuchi T, Yamada S, Hashimoto N, and S Miyamoto S
    • Journal Title

      Neurol Med Chir

      Volume: 50 Pages: 622-6

    • NAID

      10026651242

    • Related Report
      2010 Final Research Report
  • [Journal Article] 皮質形成異常の診断と外科治療2010

    • Author(s)
      三國信啓
    • Journal Title

      Epilepsy

      Volume: 4 Pages: 35-42

    • Related Report
      2010 Final Research Report
  • [Journal Article] 覚醒下手術と大脳機能局在2010

    • Author(s)
      三國信啓
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 28 Pages: 1115-1117

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小児てんかんに対する外科的治療2010

    • Author(s)
      三國信啓
    • Journal Title

      脳神経外科ジャーナル

      Volume: 19 Pages: 321-331

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] Intravenous methylprednisolone reduces the risk of propofol-induced adverse effects during Wada testing2010

    • Author(s)
      Mikuni N., et al.
    • Journal Title

      Neurol Med Chir

      Volume: 50 Pages: 622-626

    • NAID

      10026651242

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative quality of life outcome and employment in patients undergoing resection of epileptogenic lesions detected by magnetic resonance imaging2009

    • Author(s)
      Moritake K, Mikuni N, Akiyama Y, Nagai H, Maruyama N, Takada D, Daisu M, Nagasako N, Hashimoto N
    • Journal Title

      Neurol Med Chir

      Volume: 49(7) Pages: 281-286

    • NAID

      10025948066

    • Related Report
      2010 Final Research Report
  • [Journal Article] Negative motor seizure arising from the negative motor area : Is it ictal apraxia?2009

    • Author(s)
      Ikeda A, Hirasawa KI, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouchi M, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Epilepsia

      Volume: 50(9) Pages: 2072-84

    • Related Report
      2010 Final Research Report
  • [Journal Article] Postoperative quality of life outcome and employment in patients undergoing resection of epileptogenic lesions detected by magnetic resonance imaging.2009

    • Author(s)
      Moritake K, Mikuni N
    • Journal Title

      Neurol Med Chir 49

      Pages: 281-286

    • NAID

      10025948066

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal dynamics of Japanese morphogram and syllabogram processing in the left Basal temporal area studied by event-related potentials.2009

    • Author(s)
      Usui K, Ikeda A, Nagamine T, Matsuhashi M, Kinoshita M, Mikuni N, Miyamoto S, Hashimoto N, Fukuyama H, Shibasaki H.
    • Journal Title

      Clin Neurophysiol. 26

      Pages: 160-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] てんかんを持つ脳腫瘍性病変に対する外科的治療2009

    • Author(s)
      三國信啓
    • Journal Title

      脳神経外科ジャーナル 18

      Pages: 596-599

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative motor seizure arising from the negative motor area : Is it ictal apraxia?2009

    • Author(s)
      Ikeda A, Hirasawa KI, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouch M, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H., Takahashi R.
    • Journal Title

      Epilepsia 50(9)

      Pages: 2072-2084

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term seizure outcome in patients undergoing resection of lesions detected by magnetic resonance imaging2008

    • Author(s)
      Moritake K, Mikuni N, Akiyama Y, Nagai H, Maruyama N, Takada D, Sugimoto K, Nagasako N, Hashimoto N.
    • Journal Title

      Neurol Med Chir

      Volume: 48 Pages: 546-51

    • NAID

      110007008460

    • Related Report
      2010 Final Research Report
  • [Journal Article] Usefulness of MEG magnetometer for spike detection in patients with mesial temporal epileptic focus2008

    • Author(s)
      Enatsu R, Mikuni N
    • Journal Title

      Neuroimage 41

      Pages: 1206-1219

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ランチョンセミナー:てんかん外科治療の適応と実際2011

    • Author(s)
      三國信啓
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟
    • Year and Date
      2011-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかんの手術について.2011

    • Author(s)
      三國信啓
    • Organizer
      日本てんかん協会北海道支部記念講演会
    • Place of Presentation
      旭川
    • Year and Date
      2011-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかんの外科治療2011

    • Author(s)
      三國信啓
    • Organizer
      第13回北海道脳神経外科手術研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脳機能を意識した脳神経外科手術2011

    • Author(s)
      三國信啓
    • Organizer
      第89回道南脳神経外科懇話会
    • Place of Presentation
      函館
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳機能を意識した脳神経外科手術2011

    • Author(s)
      三國信啓
    • Organizer
      第14回脳血管外科治療セミナー
    • Place of Presentation
      豊中
    • Year and Date
      2011-01-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] てんかん外科医としての取り組み2011

    • Author(s)
      三國信啓
    • Organizer
      札幌臨床てんかん集談会特別講演会
    • Place of Presentation
      札幌
    • Year and Date
      2011-01-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] コントロール不良例から学ぶ:側頭葉てんかん(シンポジウム)2011

    • Author(s)
      三國信啓
    • Organizer
      第34回日本てんかん外科学会
    • Place of Presentation
      広島
    • Year and Date
      2011-01-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Integrated functional neuronavigation during neurosurgery2010

    • Author(s)
      Mikuni N, Susumu M
    • Organizer
      ICCN
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脳神経外科疾患に伴うてんかんの治療戦略.2010

    • Author(s)
      三國信啓
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳神経外科疾患に伴うてんかんの治療戦略(ランチョンセミナー)2010

    • Author(s)
      三國信啓
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 機能的ニューロナビゲーションと脳電気刺激の相補的利用による病変摘出(シンポジウム)2010

    • Author(s)
      三國信啓
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳機能を意識した脳神経外科手術2010

    • Author(s)
      三國信啓
    • Organizer
      東北のてんかん治療を考える会
    • Place of Presentation
      仙台
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] てんかんの外科治療進歩について2010

    • Author(s)
      三國信啓
    • Organizer
      第19回専門職・患者・家族のためのてんかん医学連続講座
    • Place of Presentation
      京都
    • Year and Date
      2010-07-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳機能を意識したグリオーマ手術2010

    • Author(s)
      三國信啓
    • Organizer
      第1回京都脳腫瘍セミナー
    • Place of Presentation
      京都(特別講演)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳機能を意識した脳神経外科手術2010

    • Author(s)
      三國信啓
    • Organizer
      第30回脳神経外科医のための臨床教育研究会
    • Place of Presentation
      札幌(特別講演)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児神経外科のABC.2010

    • Author(s)
      三國信啓
    • Organizer
      第38回日本小児神経外科学会
    • Place of Presentation
      富山
    • Year and Date
      2010-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかん外科の進歩海馬切除術.2010

    • Author(s)
      三國信啓
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-06
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかん外科の進歩 海馬切除術(プレナリーセッション)2010

    • Author(s)
      三國信啓
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] てんかんに対する覚醒下手術.2010

    • Author(s)
      三國信啓
    • Organizer
      第19回脳神経外科手術と機器学会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-20
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかんに対する覚醒下手術2010

    • Author(s)
      三國信啓
    • Organizer
      第19回脳神経外科手術と機器学会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳神経外科領域におけるFiber trackingの有効性と生理学的意義の検討2010

    • Author(s)
      三國信啓
    • Organizer
      第33回日本脳神経CI学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳機能部位病変に対する生理学的アプローチ2010

    • Author(s)
      三國信啓
    • Organizer
      第427回福岡臨床と脳波懇話会
    • Place of Presentation
      福岡
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 選択的扁桃体海馬切除術側頭下アプローチ.2010

    • Author(s)
      三國信啓
    • Organizer
      第33回てんかん外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 選択的扁桃体海馬切除術-側頭下アプローチ2010

    • Author(s)
      三國信啓
    • Organizer
      第33回日本てんかん外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリオーマ摘出におけるFiber trackingの意義2009

    • Author(s)
      三國信啓
    • Organizer
      第14回日本脳腫瘍の外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳機能を意識した脳神経外科手術2009

    • Author(s)
      三國信啓
    • Organizer
      第11回広島機能的脳神経外科研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epilepsy Surgery preserving functions.2009

    • Author(s)
      Mikuni N
    • Organizer
      The 2nd Korean-Japanese Epilepsy Society Symposium
    • Place of Presentation
      Hirosaki, Japan
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳神経外科開頭手術後のてんかんに対する予防と治療.2009

    • Author(s)
      三國信啓
    • Organizer
      第43回日本てんかん学会
    • Place of Presentation
      弘前
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳神経外科開頭手術後のてんかんに対する予防と治療2009

    • Author(s)
      三國信啓
    • Organizer
      第43回日本てんかん学会
    • Place of Presentation
      弘前
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 解剖学的・生理学的脳機能評価導入によるグリオーマ摘出手術長期成績2009

    • Author(s)
      三國信啓
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動機能評価に覚醒下手術は有用か?2009

    • Author(s)
      三國信啓
    • Organizer
      第6回日本Awake Surgery研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-08-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 私たちの工夫と基本手技 覚醒下手術の意義2009

    • Author(s)
      三國信啓
    • Organizer
      第24回京滋脳神経外科ビデオシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ビデオで学ぶ手術のツボ 選択的海馬切除術2009

    • Author(s)
      三國信啓
    • Organizer
      第29回日本脳神経外科コングレス総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 治療成績向上のための覚醒下脳神経外科手術2009

    • Author(s)
      三國信啓
    • Organizer
      第18回脳神経外科手術と機器学会
    • Place of Presentation
      秋田
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新皮質てんかんの外科治療.2009

    • Author(s)
      三國信啓
    • Organizer
      第50回京滋てんかん懇話会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 新皮質てんかんにおける焦点同定と摘出のための検討.2009

    • Author(s)
      三國信啓
    • Organizer
      第32回てんかん外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 教育セミナー : 脳機能と病態に基づいたてんかん焦点切除術2008

    • Author(s)
      三國信啓
    • Organizer
      第42回日本てんかん学会(教育セミナー)
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Book] 腫瘍2011

    • Author(s)
      三國信啓
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 機能的脳神経外科2011

    • Author(s)
      三國信啓
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 機能的脳神経外科.児玉南海雄監修.標準脳神経外科改訂第12版2011

    • Author(s)
      三國信啓
    • Publisher
      医学書院(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] てんかん焦点診2010

    • Author(s)
      三國信啓
    • Publisher
      シュプリンガージャパン
    • Related Report
      2010 Final Research Report
  • [Book] 側頭葉・後頭葉の手術後頭葉てんかんの手術2010

    • Author(s)
      三國信啓
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Final Research Report
  • [Book] 内側側頭葉てんかん:手術適応の判断基準と治療戦略は?2010

    • Author(s)
      三國信啓
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 内側側頭葉てんかん:手術適応の判断基準と治療戦略は?.宮本享、鈴木倫保、渋井壮一郎、中瀬裕之編.EBM脳神経外科疾患の治療2011-20122010

    • Author(s)
      三國信啓
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
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Published: 2008-04-01   Modified: 2016-04-21  

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