| Project/Area Number |
20592293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
TANAKA Yoshinobu Aichi Gakuin University, 歯学部, 教授 (60014271)
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Shogo 愛知学院大学, 歯学部, 准教授 (50323720)
NAKAMURA Yoshinori 愛知学院大学, 歯学部, 准教授 (70308782)
小島 規永 愛知学院大学, 歯学部, 非常勤助教 (30469001)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 変動磁揚 / 骨芽細胞 / 遺伝子発現 / マイクロアレイ / 変動磁場 / 石灰化 |
|---|
| Research Abstract |
This experimental study describes extremely low magnetic fields (ELMF) of 0.4T and 0.17Hz stimulated mouse osteoblast-like cell proliferation at early stage, and differentiation to mature osteoblasts, whereas fibroblasts did not show significant differences in proliferation by the exposure. These results suggested that osteoblasts have specific response on the magnetic fields, and then bone formation could be accelerated through stimulated osteoblasts by ELMF. Microarray gene analysis revealed that ELMF stimulated genes expressions were extracted.
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