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Regulation of mast cell differentiation and function by Notch signaling and its involvement in allergic inflammatory disease

Research Project

Project/Area Number 20790817
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionJuntendo University

Principal Investigator

NAKANO Nobuhiro  Juntendo University, 大学院・医学研究科, 助教 (30420839)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアレルギー / マスト細胞 / Notch / 抗原提示 / Th2 / Notchシグナル / MHC class II
Research Abstract

We demonstrated that mast cells constitutively expressed Notch1 and Notch2 on the cell surface, and Notch signaling induced the expression of MHC class II molecules and the costimulatory molecule OX40L on the mast cells. Furthermore, we showed that MHC class II+OX40L+ mast cells functioned as an antigen-presenting cell for CD4+ T cells and induced the differentiation of Th2. These results suggest that the mast cells as the antigen-presenting cells involve in the development of allergic diseases.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (7 results) Remarks (2 results)

  • [Journal Article] Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes2009

    • Author(s)
      Potaczek DP, Wang QH, Sanak M, Tokura T, Matsuda H, Dziedzina S, Nakano N, Hara M, Ogawa H, Szczeklik A, Okumura K, Nishiyama C.
    • Journal Title

      Tissue Antigens 74

      Pages: 534-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] FcεRIαgene -18483A>C polymorphism affects transcriptional activity through YY1 binding2009

    • Author(s)
      Potaczek DP, Maeda K, Wang QH, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C.
    • Journal Title

      Immunogenetics 61

      Pages: 649-55

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of PU. 1 in the transcriptional regulation of TNF-α2009

    • Author(s)
      Fukai T, Nishiyama C, Kanada S, Nakano N, Hara M, Tokura T, Ikeda S, Ogawa H, Okumura K.
    • Journal Title

      Biochem Biophys Res Commun 388

      Pages: 102-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PU. 1 in monocyte- and mast cell-specific gene regulation: PU. 1 transactivates CIITA pIV in cooperation with IFN-γ2009

    • Author(s)
      Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K.
    • Journal Title

      Int Immunol 21

      Pages: 803-16

    • NAID

      10025387178

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009

    • Author(s)
      Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K.
    • Journal Title

      J Allergy Clin Immunol 123

      Pages: 74-81

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.2009

    • Author(s)
      Potaczek D.P., et al.
    • Journal Title

      Tissue Antigens 74

      Pages: 534-538

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FcεRIα gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.2009

    • Author(s)
      Potaczek D.P., et al.
    • Journal Title

      Lmmunogenetics 61

      Pages: 649-655

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of PU.1 in the transcriptional regulation of TNF-α.2009

    • Author(s)
      Fukai T, et al.
    • Journal Title

      Biochem Biophys Res Commun 388

      Pages: 102-106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PU.1 in monocyte- and mast cell-specific gene regulation : PU.1 transactivates CIITA pIV in cooperation with IFN-γ.2009

    • Author(s)
      Ito T, et al.
    • Journal Title

      Int Lmmunol. 21

      Pages: 803-816

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009

    • Author(s)
      Nakano N., et.al.
    • Journal Title

      J Allergy Clin Immunol 123

      Pages: 74-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opposite effects of PU. 1 on mast cell stimulation2008

    • Author(s)
      Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, Okumura K.
    • Journal Title

      Biochem Biophys Res Commun. 375

      Pages: 95-100

    • Related Report
      2009 Final Research Report
  • [Journal Article] Procyanidin C1 from apple extracts inhibits FcεRI-mediated mast cell activation2008

    • Author(s)
      Nakano N, Nishiyama C, Tokura T, Nagasako-Akazome Y, Ohtake Y, Okumura K, Ogawa H.
    • Journal Title

      Int Arch Allergy Immunol 147

      Pages: 213-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Opposite effects of PU.1 on mast cell stimulation.2008

    • Author(s)
      Niwa Y., et.al.
    • Journal Title

      Biochem Biophys Res Commum 375

      Pages: 95-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Procyanidin Cl from apple extracts inhibits FcsRI-mediated mast cell activation2008

    • Author(s)
      Nakano N., et.al.
    • Journal Title

      Int Arch Allergy Immunol 147

      Pages: 213-221

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of Notch receptors in acquisition of mast cell functions2009

    • Author(s)
      中野信浩
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of Notch receptors in acquisition of mast cell functions.2009

    • Author(s)
      中野信浩
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] マスト細胞の形質獲得における各種Notchリガンドの役割2009

    • Author(s)
      中野信浩
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 抗原提示細胞としてのマスト細胞の機能2009

    • Author(s)
      中野信浩
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] マスト細胞においてNotchシグナルにより誘導されるMHC class II発現のメカニズム2008

    • Author(s)
      中野信浩
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] マスト細胞においてNotchシグナルにより誘導されるMHC class II発現メカニズム2008

    • Author(s)
      中野信浩
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Notchシグナルによりマスト細胞が獲得する抗原提示細胞機能2008

    • Author(s)
      中野信浩
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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