Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Research Abstract |
In the control (0Gy) and 15Gy groups, all mice survived but 80% of the mice in the 30Gy group died 6 months after irradiation. TGF-beta expression was significantly induced from 1 day to 4 weeks in the 15Gy and 30Gy groups compared with the control and 5Gy groups. Plasma albumin was decreased immediately after liver irradiation but was gradually resolved 4 weeks after irradiation. Similarly, recovery from liver damage 4 weeks after 30Gy and 15Gy irradiation was observed using the immunohistochemical staining method but no liver fibrosis was detected. TGF-beta may predict radiation-induced liver damage and death from the damage without a close relationship with liver fibrosis.
|