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Breakthrough in non-invasive blood analysis using mid-infrared light

Research Project

Project/Area Number 20H00231
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 21:Electrical and electronic engineering and related fields
Research InstitutionTohoku University

Principal Investigator

Matsuura Yuji  東北大学, 医工学研究科, 教授 (10241530)

Co-Investigator(Kenkyū-buntansha) 片桐 崇史  富山大学, 学術研究部工学系, 教授 (90415125)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2023: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2022: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2021: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2020: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords光音響分光法 / 中赤外光 / 光熱変換分光法 / 非侵襲診断 / 光熱偏向分光分析 / 非侵襲血糖値測定 / 赤外分光 / 光音響分光 / 光熱偏向分光 / 血糖値測定 / 光熱偏向分光法 / 赤外分光法 / 量子カスケードレーザ
Outline of Research at the Start

血糖,コレステロールなどの血中成分を,指や口唇でセンサ部を触れただけで,非侵襲で精密に分析を行う装置を開発することを目的とする.本研究では,中赤外光を生体試料に垂直に入射し,光吸収により発生する「熱」または「音響波」を検出する.これにより,光の侵入深さを従来のATR法よりはるかに大きい20ミクロン程度とすることが可能であり,生体組織液の成分を高精度に測定することが期待される.「熱」を検出する方法としては,熱による屈折率変化を近赤外のプローブレーザ光で検出する光熱偏向法を,「音響波」を検出する方法は,音波もしくは超音波をとらえる光音響法を用い,実用システムの実現を目指す.

Outline of Final Research Achievements

The purpose of this project is to develop a device for analyzing blood components such as blood glucose by simply touching the sensor. We investigated a new method for detecting heat or acoustic waves generated by optical absorption of mid-infrared light incident on a biological sample, which enables precise analysis. For the detection of heat, a photothermal deflection method that detects changes in refractive index due to heat was used, and for acoustic waves, a method that detects ultrasonic waves propagating inside the body was investigated. The correlation with blood glucose level was examined, and a relatively good correlation was obtained if the measurement position was fixed.

Academic Significance and Societal Importance of the Research Achievements

本研究では,光吸収により発生する熱を検出する光熱変換分光法を導入することにより,精密に血中成分を分析可能なシステムを構築することを目的とした.最終的な開発ターゲットは,小型かつ安価な実用システムであり,将来的にはコンパクトなヘルスケア機器を構築可能となる.光熱変換分光法自体は一般的なものであるが,それを中赤外分光による生体計測へ応用するというところに,本申請の研究の学術的独自性がある.

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (42 results)

All 2024 2023 2022 2021 2020

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (31 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results)

  • [Journal Article] Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation2024

    • Author(s)
      Kino Saiko、Kanamori Masayuki、Shimoda Yoshiteru、Niizuma Kuniyasu、Endo Hidenori、Matsuura Yuji
    • Journal Title

      BMC Cancer

      Volume: 24 Issue: 1

    • DOI

      10.1186/s12885-024-11970-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mid-infrared photoacoustic spectroscopy using a quantum cascade laser for non-invasive blood component analysis2023

    • Author(s)
      Maeno Masanobu、Kino Saiko、Matsuura Yuji
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 62 Issue: 7 Pages: 072001-072001

    • DOI

      10.35848/1347-4065/ace0a8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mid-infrared photoacoustic spectroscopy based on ultrasound detection for blood component analysis2023

    • Author(s)
      Ryota Sasaki, Saiko Kino, Yuji Matsuura
    • Journal Title

      Biomedical Optics Express

      Volume: 14 Issue: 7 Pages: 3841-3852

    • DOI

      10.1364/boe.494615

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 赤外分光法による無侵襲血中脂質分析2022

    • Author(s)
      木野彩子, 松浦祐司
    • Journal Title

      Medical Science Digest

      Volume: 48 Pages: 52-53

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Healthcare-monitoring systems using mid-infrared light2022

    • Author(s)
      Y. Matsuura
    • Journal Title

      Photonics Review

      Volume: 2022 Issue: 0 Pages: n/a

    • DOI

      10.11470/photo.220203

    • ISSN
      2758-0059
    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Analysis of Trace Metals in Human Hair by Laser-Induced Breakdown Spectroscopy with a Compact Microchip Laser2021

    • Author(s)
      Nakagawa Makoto、Matsuura Yuji
    • Journal Title

      Sensors

      Volume: 21 Issue: 11 Pages: 3752-3752

    • DOI

      10.3390/s21113752

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vacuum ultraviolet absorption spectroscopy analysis of breath acetone using a hollow optical fiber gas cell2021

    • Author(s)
      Y. Kudo, S. Kino, Y. Matsuura
    • Journal Title

      Sensors

      Volume: 21 Issue: 2 Pages: 478-488

    • DOI

      10.3390/s21020478

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Compact Mid-Infrared Spectroscopy System for Healthcare Applications Based on a Wavelength-Swept, Pulsed Quantum Cascade Laser2020

    • Author(s)
      T. Koyama, N. Shibata, S, Kino, A. Sugiyama, N. Akikusa, Y. Matsuura
    • Journal Title

      Sensors

      Volume: 20 Issue: 12 Pages: 3438-3448

    • DOI

      10.3390/s20123438

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中赤外光イメージングのための反共振型中空マルチコアファイバ2020

    • Author(s)
      片桐崇史, 松浦祐司
    • Journal Title

      レーザー研究

      Volume: 48 Pages: 291-295

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 量子カスケードレーザーと中空光ファイバを用いた赤外分光システムのヘルスケア応用2020

    • Author(s)
      松浦祐司, 小山卓耶, 笠原亮介
    • Journal Title

      レーザー研究

      Volume: 48 Pages: 306-310

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convolutional neural networks for classification and regression analysis of one-dimensional spectral data2020

    • Author(s)
      Ine L. Jernelv, Dag Roar Hjelme, Yuji Matsuura,, Astrid Aksnes
    • Journal Title

      arXiv

      Volume: 5

    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Healthcare monitoring systems using mid-infrared and deep ultraviolet spectroscopy2024

    • Author(s)
      Y. Matsuura
    • Organizer
      SPIE Photonics West 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 量子カスケードレーザーを用いた中赤外領域における生体光音響イメージング2024

    • Author(s)
      田中望実, 木野彩子, 松浦祐司
    • Organizer
      レーザー学会学術講演会第44回年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 血漿ATRスペクトルの部分最小二乗判別分析による脳腫瘍判別の試み2024

    • Author(s)
      保坂春樹, 木野彩子, 金森政之, 松浦祐司
    • Organizer
      レーザー学会学術講演会第44回年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 超音波検出型中赤外光音響分光法による血中成分分析2024

    • Author(s)
      相場希衣子, 木野彩子, 松浦祐司
    • Organizer
      第71回応用物理学会春季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 中赤外光音響分光法による脳腫瘍バイオマーカーイメージングの試み2024

    • Author(s)
      田中望実, 木野彩子, 松浦祐司
    • Organizer
      第71回応用物理学会春季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mid-infrared photoacoustic spectral imaging based on ultrasound detection2023

    • Author(s)
      N.Tanaka, R.Sasaki, S.Kino, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mid-infrared Photothermal Deflection Spectroscopy System for Non-Invasive Blood Component Analysis2023

    • Author(s)
      H.Ito, S. Kino, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中赤外光音響分光法によるスペクトルイメージングー脳腫瘍バイオマーカー検出の試み―2023

    • Author(s)
      田中望実, 木野彩子, 松浦祐司
    • Organizer
      2023年第84回応用物理学会秋季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 超音波検出型中赤外光音響分光法による血中成分分析の感度向上に関する研究2023

    • Author(s)
      相場希衣子, 松浦祐司
    • Organizer
      日本光学会年次学術講演会 OPJ2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mid-infrared photoacoustic spectroscopy using piezoelectric transducer2023

    • Author(s)
      R. Sasaki, S. Kino, Y. Matsuura
    • Organizer
      SPIE Photonics West 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波検出に基づく中赤外光音響分光法を用いたハイパースペクトルイメージングの試み2023

    • Author(s)
      田中望実, 木野彩子, 松浦祐司
    • Organizer
      レーザー学会学術講演会第43回年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 中赤外光超音波分光法によるヒト生体試料の測定の試み2023

    • Author(s)
      佐々木亮太, 木野彩子, 松浦祐司
    • Organizer
      レーザー学会学術講演会第43回年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 量子カスケードレーザを用いた中赤外光音響分光法による血中成分分析2023

    • Author(s)
      前野雅信, 木野彩子, 松浦祐司
    • Organizer
      レーザー学会学術講演会第43回年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Biological Tissue Analysis by Mid-infrared Photoacoustic Spectroscopy Using Piezoelectric Transducer2022

    • Author(s)
      R. Sasaki, S. Kino, Y. Matsuura
    • Organizer
      CLEO/Pacific Rim '22
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中赤外光超音波 分光法による生体分析における感度向上の検討2022

    • Author(s)
      佐々木亮太, 木野彩子, 松浦祐司
    • Organizer
      第83回応用物理学会秋季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 超音波トランスデューサを用いた光音響分光法による生体成分イメージングの試2022

    • Author(s)
      田中望実, 松浦祐司
    • Organizer
      第83回応用物理学会秋季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 中赤外光音響分光法による非侵襲生体成分分析2022

    • Author(s)
      前野雅信, 木野彩子, 松浦祐司,
    • Organizer
      第83回応用物理学会秋季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 血漿の赤外吸収スペクトルからの脳腫瘍スクリーニングの試み2022

    • Author(s)
      木野彩子,小田直樹,金森政之,新妻邦康,冨永悌二,松浦祐司
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 圧電トランスデューサを用いた中赤外光音響分光法による生体分析-光音響信号の位相反転についての検討-2022

    • Author(s)
      佐々木亮太,木野彩子,松浦祐司
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 波長可変 QCL を用いた中赤外光音響分光法による生体組織測定2022

    • Author(s)
      前野雅信,松浦祐司
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] DFB-QCLと中空光ファイバガスセルを用いた中赤外分光法によるアンモニア検出2022

    • Author(s)
      大村勇索,木野彩子,松浦祐司
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] DFB-QCL を用いた光音響分光法によるグルコースゲル濃度測定2021

    • Author(s)
      前野雅信,松浦祐司
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中赤外光を用いた光熱偏向分光測定による生体分析 ―皮膚表面の吸収スペクトル経時変化についての検討―2021

    • Author(s)
      三上のどか,木野彩子,松浦祐司
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 第82回応用物理学会秋季学術講演会2021

    • Author(s)
      大村勇索,木野彩子,松浦祐司
    • Organizer
      波長掃引パルスQCLと中空光ファイバガスセルを用いた微小濃度ガス分析
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中赤外パルス光誘起超音波を用いた光音響分光法による生体測定の試み2021

    • Author(s)
      佐々木亮太,木野彩子,松浦祐司
    • Organizer
      日本光学会年次学術講演会 OPJ2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Quantitative analysis of acetone in breath using vacuum-ultraviolet spectroscopy based on hollow-optical-fiber gas cell2021

    • Author(s)
      Y. Kudo, Y. Matsuura
    • Organizer
      SPIE. Photonics West 2021 Digital Forum (Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement and uniformization of power distribution on the prism for biomedical applications of mid-infrared, attenuated-total-reflection spectroscopy2021

    • Author(s)
      T. Koyama, S. Kino, T. Sasaki, Y. Wada, R. Kasahara, Y. Oba, Y. Matsuura
    • Organizer
      SPIE. Photonics West 2021 Digital Forum (Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of 800-μm-bore hollow optical fibers based on completely non-fragile and flexible Ni-Ti tube for the infrared2021

    • Author(s)
      K. Iwai, H. Takaku, M. Miyagi, Y. Shi, X. Song Zhu, Y. Matsuura
    • Organizer
      SPIE. Photonics West 2021 Digital Forum (Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口唇の中赤外ATR分光スペクトルにもとづく非侵襲血糖値測定ー部分最小二乗回帰(PLSR)分析のための最適波長探索ー2021

    • Author(s)
      長谷川遼馬, 木野彩子, 松浦祐司
    • Organizer
      第68回応用物理学会春期学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Health-care system based on infrared spectroscopy using quantum cascade lasers and hollow optical fibers2020

    • Author(s)
      Y. Matsuura
    • Organizer
      The 9th Advanced Lasers and Photon Sources (ALPS2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体組織分析に向けた中赤外光熱偏向分光法による深さ方向分布測定の試み2020

    • Author(s)
      三上 のどか, 林 周作, 津田 祐樹, 秋山 浩一, 松浦 祐司
    • Organizer
      日本光学会年次学術講演会
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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