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Foods developed by nanocellulose technologies and suppressive effects of their diets and exercise on obesity

Research Project

Project/Area Number 20H01618
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionIshikawa Prefectural University

Principal Investigator

Nagano Takao  石川県立大学, 生物資源環境学部, 教授 (20304660)

Co-Investigator(Kenkyū-buntansha) 中井 雄治  弘前大学, 地域戦略研究所, 教授 (10321788)
矢野 博己  川崎医療福祉大学, 医療技術学部, 教授 (20248272)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsナノファイバー化技術 / 微粒子化 / 運動 / 肥満 / 腸内細菌叢 / メタボローム / 粘性 / 分散性 / トランスクリプトーム / ナノファイバー / 腸内フローラ
Outline of Research at the Start

ナノファイバーの製造に使用されている技術を用いて、おからなどの不溶性食物繊維を多く含む食品を微粒子化すると、比表面積、分散性、粘性が高くなる。この微粒子化による特性から、肥満抑制と腸内環境の改善による生活習慣病予防効果が期待できる。また、運動との併用によるシナジー効果も期待できる。本研究では、ナノファイバー化技術を用いておからと米ぬかの微粒子化を行い、肥満モデル動物実験系を用いて微粒子化食品と運動による肥満抑制効果を検証する。これらを通じ、生活習慣病予防に役立つ知見を得ること、肥満抑制作用を高めた食品の開発を目標とする。

Outline of Final Research Achievements

In this study, we investigated the effects of atomized food using nanofiber technology and exercise on obesity and gut microbiota using an experimental animal model system for obesity. The results showed that nanocellulose (NC) suppressed obesity and improved gut microbiota, and NC intake increased the amount of spontaneous activity in mice, improved gut microbiota, and suppressed obesity. Atomized okara inhibited amylase activity and increased butyrate production by human-predominant intestinal bacteria. Atomized okara inhibited obesity. The mechanism of the inhibition of obesity was an increase in butyrate production and bile acid biosynthesis due to the improvement of gut microbiota. The effects of the combination of atomized okara and exercise on improving gut microbiota composition and suppressing obesity were also clarified.

Academic Significance and Societal Importance of the Research Achievements

高齢化によって国民医療費は年々増加しており、医療費の抑制を目的とした生活習慣病予防は重要課題である。また、不溶性食物繊維を多く含むおからなどは、物性や食感などが問題となり食品としての利用は限られている。一方、近年、ナノセルロースが注目されてナノファイバー化技術が飛躍的に進歩した。本研究では、ナノファイバー化技術を用いて食品の微粒子化を行い、その微粒子化食品と運動による肥満抑制効果と腸内細菌叢に与える効果を検証し、それらのメカニズムを明らかにすることを目的とした。研究により、生活習慣病予防に役立つ知見、肥満抑制作用を高めた食品の開発に繋がる成果が得られたと考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (12 results)

All 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Journal Article] Effect of dietary cellulose nanofiber and exercise on obesity and gut microbiota in mice fed a high-fat-diet2020

    • Author(s)
      Nagano Takao、Yano Hiromi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 3 Pages: 613-620

    • DOI

      10.1080/09168451.2019.1690975

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary cellulose nanofiber modulates obesity and gut microbiota in high-fat-fed mice2020

    • Author(s)
      Nagano Takao、Yano Hiromi
    • Journal Title

      Bioactive Carbohydrates and Dietary Fibre

      Volume: 22 Pages: 100214-100214

    • DOI

      10.1016/j.bcdf.2020.100214

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved effects of okara atomized by a water jet system on α-amylase inhibition and butyrate production by <i>Roseburia intestinalis</i>2020

    • Author(s)
      Nagano Takao、Hirano Rika、Kurihara Shin、Nishinari Katsuyoshi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 7 Pages: 1467-1474

    • DOI

      10.1080/09168451.2020.1741337

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved physicochemical and functional properties of okara, a soybean residue, by nanocellulose technologies for food development - A review2020

    • Author(s)
      Nagano Takao、Arai Yuya、Yano Hiromi、Aoki Takafumi、Kurihara Shin、Hirano Rika、Nishinari Katsuyoshi
    • Journal Title

      Food Hydrocolloids

      Volume: 109 Pages: 105964-105964

    • DOI

      10.1016/j.foodhyd.2020.105964

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Impact of wet grinder-treated okara on obesity and gut microbiota in high-fat diet-fed mice2022

    • Author(s)
      Takao Nagano, Chihiro Watanabe, Kazuyoshi Nakamura, Eri Oyanagi and Hiromi Yano
    • Organizer
      6th International Symposium on Phytochemicals in Medicine and Food, Hangzhou, China
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノファイバー化技術を利用した食品開発2022

    • Author(s)
      長野隆男
    • Organizer
      第33回食品ハイドロコロイドシンポジウム、京都大学農学部総合館(京都)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 微粒子化おからの肥満抑制効果と短鎖脂肪酸産生に与える影響2021

    • Author(s)
      中村和詳、渡邉知央、荒井雄也、小柳えり、矢野博己、長野隆男
    • Organizer
      2021年度日本食品科学工学会 中部支部大会(静岡)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Impact of dietary soyasaponins on contact hypersensitivity and gut microbiota in mice.2021

    • Author(s)
      Takao Nagano, Anh Le Thi, Kazuyoshi Nakamura, Yuya Arai, Mitsuru Katase, Kazunobu Tsumura
    • Organizer
      5th International Symposium on Phytochemicals in Medicine and Food, Nanchang, China
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノセルロース摂取と運動が肥満抑制と腸内フローラに与える効果2020

    • Author(s)
      長野 隆男、矢野 博己
    • Organizer
      第74 回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ナノセルロース摂取が肥満と腸内フローラに与える影響2020

    • Author(s)
      長野 隆男、矢野 博己
    • Organizer
      第72 回日本家政学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Applying nanotechnology to okara for developing soy protein gel-based foods2020

    • Author(s)
      Yuya Arai, Katsuyoshi Nishinari, Takao Nagano
    • Organizer
      The 1st International Electronic Conference on Food Science and Functional Foods
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of dietary cellulose nanofibrils on obesity and gut microbiota in high-fat diet-fed mice2020

    • Author(s)
      Takao Nagano, Kazuyoshi Nakamura, Yuka Yokogawa, Suzuka Miura, Chihiro Watanabe, Eri Oyanagi, Hiromi Yano
    • Organizer
      4th International Symposium on Phytochemicals in Medicine and Food
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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